Activation of NK cell (human and mouse) by immunostimulatory DNA sequence

Springer Seminars in Immunopathology

Volumn 22, Issue 1-2, 2000, Pages 35-43

  Yamamoto, Saburo ^a   Yamamoto, Toshiko ^a   Iho, Sumiko ^b   Tokunaga, Tohru ^c  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c Fukuoka Jo Gakuin University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; BETA INTERFERON; CARRAGEENAN; CYTOSINE; GAMMA INTERFERON; GANGLIOTETRAOSYLCERAMIDE; GUANOSINE PHOSPHATE; IMMUNOGLOBULIN G; INTERFERON; LIPOPOLYSACCHARIDE; MACROPHAGE ACTIVATING FACTOR; PALINDROMIC DNA; SCAVENGER RECEPTOR; SINGLE STRANDED DNA;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; BINDING AFFINITY; BRUCELLA ABORTUS; CELL ACTIVATION; CELL INFILTRATION; CYTOTOXICITY; DNA SEQUENCE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; SEQUENCE ANALYSIS; SPLEEN CELL;

EID: 0033749739     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002810050013     Document Type: Review

References (26)

1. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
2. Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein
3. Characterization and modulation of immune stimulation by modified oligonucleotides
4. Oligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-γ production in vitro
5. Antitumor activity of synthetic oligonucleotides with sequences from cDNA encoding proteins of Mycobacterium bovis BCG
6. Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN
7. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
8. CpG motifs in bacterial DNA trigger direct B-cell activation
9. In situ infiltration of natural killer-like cells induced by intradermal injection of the nucleic acid fraction from BCG
10. Oligonucleotide sequences required for natural killer cell activation
11. In vitro augmentation of natural killer activity of peripheral blood cells from cancer patients by a DNA fraction from Mycobacterium bovis BCG
12. Immune stimulation - A class effect of phosphorothioate oligonucleotides in rodents
13. Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants
14. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
15. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors
16. In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG
17. Hexamer palindromic oligonucleotides with 5'-CG-3' motif(s) induce production of interferon
18. Gene vaccination: Plasmid DNA is more than just a blueprint
19. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
20. Synthetic oligonucleotides with particular base sequences from the cCNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
21. In vitro augmentation of natural killer cell activity and production of interferon-α/β and -γ with deoxyribonucleic acid fraction from Mycobacterium bovis BCG
22. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
23. Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro
24. Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity
25. Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length
26. CpG motifs in bacterial DNA activate leukocytes though the pH-dependent generation of reactive oxygen species