Rapid methods for screening low molecular mass compounds non-covalently bound to proteins using size exclusion and mass spectrometry applied to inhibitors of human cytomegalovirus protease

Journal of Mass Spectrometry

Volumn 33, Issue 3, 1998, Pages 264-273

  Siegel, Marshall M ^a   Tabei, Keiko ^a   Bebernitz, Geraldine A ^a   Baum, Ellen Z ^a,b  

^a WYETH RESEARCH   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

Drug screening; Electrospray ionization mass spectrometry; Gel permeation chromatography; Human cytomegalovirus protease; Inhibitors; Microconcentration; Non covalent complexes; Proteins; Size exclusion chromatography; Ultrafiltration

Indexed keywords

PROTEINASE INHIBITOR;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COVALENT BOND; CYTOMEGALOVIRUS; DRUG SCREENING; ENZYME INHIBITION; GEL PERMEATION CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

BINDING, COMPETITIVE; CHROMATOGRAPHY, GEL; CYTOMEGALOVIRUS; HUMANS; MASS SPECTROMETRY; MOLECULAR WEIGHT; PROTEASE INHIBITORS; PROTEIN BINDING; ULTRAFILTRATION;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0031917284     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9888(199803)33:3<264::AID-JMS629>3.0.CO;2-2     Document Type: Article

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