Biosensor analysis of drug-target interactions: Direct and competitive binding assays for investigation of interactions between thrombin and thrombin inhibitors

Analytical Biochemistry

Volumn 278, Issue 1, 2000, Pages 1-13

  Karlsson, Robert ^a   Kullman Magnusson, Mari ^a   Hämäläinen, Markku D ^a   Remaeus, Annika ^a   Andersson, Karl ^a   Borg, Peter ^a   Gyzander, Erika ^b   Deinum, Johanna ^b  

^a BIACORE AB   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Biacore; Secondary screening; Thrombin

Indexed keywords

SOLVENTS;

BIACORE; BINDING SPECIFICITIES; COMPETITIVE BINDING ASSAY; DRUG-TARGET INTERACTIONS; IMMOBILIZED PROTEINS; LOW MOLECULAR WEIGHT COMPOUNDS; SECONDARY SCREENING; THROMBIN;

ENZYMES;

CRYSTAL VIOLET; DEXTRAN; DIMERCAPROL; DIMETHADIONE; DIMETHOXYCOUMARIN; DIOXYBENZONE; DIPHENHYDRAMINE; DIPHENYLPYRALINE; DIPROPHYLLINE; DIPYRIDAMOLE; DISOPYRAMIDE PHOSPHATE; DOPAMINE; ERGOCALCIFEROL; ERGOTAMINE TARTRATE; ERYTHROMYCIN STEARATE; ESTRIOL; GRAMICIDIN; HETACILLIN; HEXACHLOROPHENE; HEXETIDINE; MERBROMIN; METHOCARBAMOL; METHYLDOPA; METOPROLOL; METRONIDAZOLE; NAPHAZOLINE; NEOCOBEFRIN; NICOTINIC ACID; NIFEDIPINE; NITROFURANTOIN; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING COMPETITION; BIOSENSOR; COMPETITIVE INHIBITION; DEVICE; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMETHOD COMPARISON; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; RELIABILITY; TECHNOLOGY;

VIOLA (ANGIOSPERM);

EID: 0034141443     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1999.4406     Document Type: Article

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