'One-pot' methylation of Fmoc amino acids

Tetrahedron Letters

Volumn 37, Issue 2, 1996, Pages 263-266

  Luke, Richard W A ^a   Boyce, Patrick G T ^a   Dorling, E Kate ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHYLATION;

EID: 0030028651     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02145-0     Document Type: Article

References (7)

1. Initial results were presented at the First Australian Peptide Conference, Queensland, 16-21st October 1994.
2. Abbreviations: Fmoc, fluorenylmethoxycarbonyl; TFA, trifluoroacetic acid; TES, triethylsilane; RP-HPLC, Reverse Phase - High Performance Liquid Chromatography.
3. R.M. Freidinger, J.S. Hinkle, D.S. Perlow, and B.H. Arison, J. Org. Chem. 1983, 48, 77-81.
4. All new compounds gave the expected proton NMR spectra, mass spectra and either accurate mass or microanalysis.
5. -; found, C, 74.2, H, 5.42, N, 3.5, theory, C, 74.4, H, 5.46, N, 3.62.
6. H.E. Zaugg and W.B. Martin, Org. React. 1965, 14, 52.
7. 5).