Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene

Biochemical Journal

Volumn 368, Issue 2, 2002, Pages 657-663

  Tomás Cobos, Lidia ^a   Sanz, Pascual ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Glucose induction; Glucose repression; Two hybrid interaction

Indexed keywords

ENZYME INHIBITION; FUNGI; GENES; GLUCOSE;

TRANSCRIPTION FACTORS;

PROTEINS;

GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER HXT1; PROTEIN KINASE; PROTEIN KINASE SNF1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RGT1; TRANSCRIPTION FACTOR SSN6; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE REPRESSION; GLUCOSE TRANSPORT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE;

BIOLOGICAL TRANSPORT; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GLUCOSE; MONOSACCHARIDE TRANSPORT PROTEINS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATORS;

EUKARYOTA; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0036905343     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020984     Document Type: Article

References (44)

1. Carlson, M. (1999) Glucose repression in yeast. Curr. Opin. Microbiol. 2, 202-207
2. Gancedo, J. M. (1998) Yeast carbon catabolite repression. Microbiol. Mol. Biol. Rev. 62, 334-361
3. Rolland, F., Winderickx, J. and Thevelein, J. M. (2001) Glucose-sensing mechanisms in eukaryotic cells. Trends Biochem. Sci. 26, 310-317
4. Jiang, R. and Carlson, M. (1997) The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex. Mol. Cell. Biol. 17, 2099-2106
5. Jiang, R. and Carlson, M. (1996) Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev. 10, 3105-3115
6. Alms, G. R., Sanz, P., Carlson, M. and Haystead, T. A. (1999) Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase PII in Saccharomyces cerevisiae: Characterizing the effects of a phosphatase subunit on the yeast proteome. EMBO J. 18, 4157-4168
7. Dombeck, K. M., Voronkova, V., Raney, A. and Young, E. T. (1999) Functional analysis of the yeast Glc7-binding protein Reg1 identifies a protein phosphatase type 1-binding motif as essential for repression of ADH2 expression. Mol. Cell. Biol. 19, 6029-6040
8. Tu, J. and Carlson, M. (1995) REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 14, 5939-5946
9. Ludin, K., Jiang, R. and Carlson, M. (1998) Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 95, 6245-6250
10. Sanz, P., Alms, G. R., Haystead, T. A. and Carlson, M. (2000) Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase. Mol. Cell. Biol. 20, 1321-1328
11. Johnston, M. (1999) Feasting, fasting and fermenting. Trends Genet. 15, 29-33
12. Ozcan, S. and Johnston, M. (1999) Function and regulation of yeast hexose transporters. Microbiol. Mol. Biol. Rev. 63, 554-569
13. Ozcan, S., Dover, J., Rosenwald, A. G., Wolfl, S. and Johnston, M. (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl. Acad. Sci. U.S.A. 93, 12428-12432
14. Ozcan, S., Dover, J. and Johnston, M. (1998) Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. EMBO J. 17, 2566-2573
15. Li, F. N. and Johnston, M. (1997) Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: Coupling glucose sensing to gene expression and the cell cycle. EMBO J. 16, 5629-5638
16. Kishi, T., Seno, T. and Yamao, F. (1998) Grr1 functions in the ubiquitin pathway in Saccharomyces cerevisiae through association with Skp1. Mol. Gen. Genet. 257, 143-148
17. Ozcan, S., Leong, T. and Johnston, M. (1996) Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol. Cell. Biol. 16, 6419-6426
18. Schmidt, M. C., McCartney, R. R., Zhang, X., Tillman, T. S., Solimeo, H., Wolfl, S., Almonte, C. and Watkins, S. C. (1999) Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 4561-4571
19. Lafuente, M. J., Gancedo, C., Jauniaux, J. C. and Gancedo, J. M. (2000) Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiae. Mol. Microbiol. 35, 161-172
20. Ozcan, S. and Johnston, M. (1995) Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol. 15, 1564-1572
21. Rothstein, R. J. (1983) One-step gene disruption in yeast. Methods Enzymol. 101C, 202-210
22. Alani, E. and Kleckner, N. (1987) A new type of fusion analysis applicable to many organisms: Protein fusions to the URA3 gene of yeast. Genetics 117, 5-12
23. Wach, A., Brachat, A., Pöhlmann, R. and Philippsen, P. (1994) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808
24. Rose, M. D., Winston, F. and Hieter, P. (1990) Methods in Yeast Genetics, a Laboratory Course Manual, Cold Spring Harbor Press, Cold Spring Harbor, NY
25. Legrain, P., Dokhelar, M.-C. and Transy, C. (1994) Detection of protein-protein interactions using different vectors in the two-hybrid system. Nucleic Acids Res. 22, 3241-3242
26. Golemis, E. A., Serbriiskii, I., Gyuris, J. and Brent, R. (1997) Interaction Trap/two-hybrid system to identify interacting proteins. In Current Protocols in Molecular Biology, vol. 3 (Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. and Struhl, K., eds.), pp. 20.1.1-20.1.35, John Wiley & Sons, New York
27. Song, W. and Carlson, M. (1998) Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1. EMBO J. 17, 5757-5765
28. Kim, J. and Hirsch, J. P. (1998) A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone. Genetics 149, 795-805
29. Sikorski, R. S. and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27
30. Treitel, M. A., Kuchin, S. and Carlson, M. (1998) Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae. Mol. Cell. Biol. 18, 6273-6280
31. Mayordomo, I. and Sanz, P. (2001) Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast 18, 1309-1316
32. Goldstein, A. and Lampen, J. O. (1975) Beta-D-fructofuranoside fructohydrolase from yeast. Methods Enzymol. 42, 504-511
33. Kuchin, S., Treich, I. and Carlson, M. (2000) A regulatory shortcut between the Snf1 protein kinase and RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. U.S.A. 97, 7916-7920
34. Lo, W. S., Duggan, L., Emre, T. N. C., Belotserkovskya, R., Lane, W. S., Shiekhattar, R. and Berger, S. L. (2001) Snf1 - A histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science 293, 1142-1146
35. Leclerc, I., Kahn, A. and Doiron, B. (1998) The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett. 431, 180-184
36. Foretz, M., Carling, D., Guichard, C., Ferre, P. and Foufelle, F. (1998) AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J. Biol. Chem. 273, 14767-14771
37. Woods, A., Azzout-Marniche, D., Foretz, M., Stein, S. C., Lemarchand, P., Ferre, P., Foufelle, F. and Carling, D. (2000) Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol. Cell. Biol. 20, 6704-6711
38. da Silva Xavier, G., Leclerc, I., Salt, I. P., Doiron, B., Hardie, D. G., Kahn, A. and Rutter, G. A. (2000) Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc. Natl. Acad. Sci. U.S.A. 97, 4023-4028
39. Hubbard, E. J., Jiang, R. and Carlson, M. (1994) Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 1972-1978
40. DeVit, M. J., Waddle, J. A. and Johnston, M. (1997) Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8, 1603-1618
41. Johnston, M., Brachet, V., Polish, J. and Kim, J.-H. (2001) Glucose sensing and signal transduction. Yeast 18, S25
42. Cooper, J. P., Roth, S. Y. and Simpson, R. T. (1994) The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev. 8, 1400-1410
43. Keleher, C. A., Redd, M. J., Schultz, J., Carlson, M. and Johnson, A. D. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68, 709-719
44. Thomas, B. J. and Rothstein, R. (1989) Elevated recombination rates in transcriptionally active DNA. Cell 56, 619-630