Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae

EMBO Journal

Volumn 17, Issue 9, 1998, Pages 2566-2573

  Özcan, Sabire ^a   Dover, Jim ^a   Johnston, Mark ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glucose; Glucose transporter; Rgt2; Snf3; Yeast

Indexed keywords

GLUCORECEPTOR; GLUCOSE; GLUCOSE TRANSPORTER;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; ENERGY RESOURCE; EUKARYOTIC CELL; GENE EXPRESSION; GENE INDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; YEAST;

AMINO ACID SEQUENCE; BASE SEQUENCE; BETA-GALACTOSIDASE; CONSENSUS SEQUENCE; DNA PRIMERS; GENE EXPRESSION REGULATION, FUNGAL; GENOTYPE; GLUCOSE; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MONOSACCHARIDE TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0032080298     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.9.2566     Document Type: Article

References (43)

1. Barrai,Y., Jentsch,S. and Mann,C. (1995) G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev., 9, 399-409.
2. Bisson,L.F., Coons,D.M., Kruckeberg,A.L. and Lewis,D.A. (1993) Yeast sugar transporters. Crit. Rev. Biochem. Mol. Biol., 28, 259-308.
3. Boles,E. and Hollenberg,C.P. (1997) The molecular genetics of hexose transport in yeasts. FEMS Microbiol. Rev., 21, 85-111.
4. Celenza,J.L., Marshall-Carlson,L. and Carlson,M. (1988) The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein. Proc. Natl Acad. Sci. USA, 85, 2130-2134.
5. Christianson,T.W., Sikorski,R.S., Dante,M., Shero,J.H. and Hieter,P. (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene, 110, 119-122.
6. Coons,D.M., Boulton,R.B. and Bisson,L.F. (1995) Computer-assisted nonlinear regression analysis of the multicomponent glucose uptake kinetics of Saccharomyces cerevisiae. J. Bacteriol., 177, 3251-3258.
7. Coons,D.M., Vagnoli,P. and Bisson,L.F. (1997) The C-terminal domain of Snf3p is sufficient to complement the growth defect of snf3 null mutations in Saccharomyces cerevisiae: SNF3 functions in glucose recognition. Yeast, 13, 9-20.
8. Entian,K.-D., Kopetzki,E., Fröhlich,K.U. and Mecke,D. (1984) Cloning of hexokinase isoenzyme PI from Saccharomyces cerevisiae: PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts. Mol. Gen. Genet., 198, 50-54.
9. Erickson,J.R. and Johnston,M (1994) Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae. Genetics, 136, 1271-1278.
10. Flick,J.S. and Johnston,M. (1991) GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucinerich repeats. Mol. Cell Biol., 11, 5101-5112.
11. Gietz,R.D. and Sugino,A. (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene, 74, 527-534.
12. Jiang,H., Medintz,I. and Michels,C.A. (1997) Two glucose sensing/ signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces. Mol. Biol. Cell, 8, 1293-1304.
13. Johnston,M. and Davis,R.W. (1984) Sequences that regulate GAL1-GAL10 promoter in S.cerevisiae. Mol. Cell. Biol., 4, 1440-1448.
14. Ko,C.H., Liang,H. and Gaber,R.F. (1993) Roles of multiple glucose transporters in Saccharomyces cerevisiae. Mol. Cell. Biol., 13, 638-648.
15. Kruckeberg, A.L. (1996) The hexose transporter family of Saccharomyces cerevisiae. Arch. Microbiol., 166, 283-292.
16. Li,F.N. and Johnston,M. (1997) Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle. EMBO J., 16, 5629-5638.
17. Liang,H. and Gaber,R.F. (1996) A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6. Mol. Biol. Cell, 7, 1953-1966.
18. Lorenz,M. and Heitman,J. (1996) Ammonia permeases are receptors for pseudohyphal growth. In Abstracts of the 1996 Yeast Genetics and Molecular Biology Meeting, Madison, WI. p. 3B.
19. Madi,L., McBride,A., Bailey,L.A. and Ebbole,D.J. (1997) rco-3, a gene involved in glucose transport and conidiation in Neurospora crassa. Genetics, 146, 499-508.
20. Marshall-Carlson,L., Celenza,J.L., Laurent,B.C. and Carlson,M. (1990) Mutational analysis of the SNF3 glucose transporter of Saccharomyces cerevisiae. Mol. Cell. Biol., 10, 1105-1115.
21. Marshall-Carlson,L., Neigeborn,L., Coons,D., Bisson,L. and Carlson,M. (1991) Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Genetics, 128, 505-512.
22. Neigeborn,L., Schwartzberg,P., Reid,R. and Carlson,M. (1986) Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations. Mol. Cell. Biol., 6, 3569-3574.
23. Niedenthal,R.K., Riles,L., Johnston,M. and Hegemann,J.H. (1996) Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast. Yeast, 12, 773-786.
24. Özcan,S. and Johnston,M. (1995) Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol., 15, 1564-1572.
25. Özcan,S. and Johnston,M. (1996) Two different repressors collaborate to restrict the yeast glucose transporter genes HXT2 and HXT4 to low levels of glucose. Mol. Cell. Biol., 16, 5536-5545.
26. Özcan,S., Schulte,F., Freidel,K., Weber,A. and Ciriacy,M. (1994) Glucose uptake and metabolism in grr1/cat80 mutants of Saccharomyces cerevisiae. Eur. J. Biochem., 224, 605-611.
27. Özcan,S., Leong,T. and Johnston,M. (1996a) Rgt1 of S.cerevisiae, a key regulator of glucose-induced genes, is both an activator and represser of transcription. Mol. Cell. Biol., 16, 1564-1572.
28. Özcan,S., Dover,J., Rosenwald,A.G., Wölfl,S. and Johnston,M. (1996b) Two glucose transporters in S.cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl Acad. Sci. USA, 93, 12428-12432.
29. Özcan,S., Vallier,L.G., Flick,J.S., Carlson,M. and Johnston,M. (1997) Expression of the SUC2 gene of Saccharomyces cerevisiae is induced by low levels of glucose. Yeast, 13, 127-137.
30. Parkinson,J.S., and Kofoid,E.C. (1992) Communication modules in bacterial signaling proteins. Annu. Rev. Genet., 26, 71-112.
31. Postma,P.W., Lengeler,J.W. and Jacobson,G.R. (1993) Phosphoenol-pyruvate:carbohydrate phosphotransferase systems of bacteria. Microbiol. Rev., 57, 543-594.
32. Reifenberger,E., Freidel,K. and Ciriacy,M. (1995) Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux. Mol. Microbiol., 16, 157-167.
33. Reifenberger,E., Boles,E. and Ciriacy,M. (1997) Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their regulation to the triggering mechanisms of glucose repression. Eur. J. Biochem., 245, 324-333.
34. Saier,M.H.Jr, Chauvaux,S., Cook,G.M., Deutscher,J., Paulsen,I.T., Reizer,J. and Ye,J.J. (1996) Catabolite repression and inducer control in Gram-positive bacteria. Microbiology, 142, 217-230.
35. Saraste,M., Sibbald,P.R. and Wittinghofer,A. (1990) The P-loop - a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci., 15, 430-434.
36. Schlax,P.J., Capp,M.W. and Record,M.T.Jr (1995) Inhibition of transcription initiation by lac represser. J. Mol. Biol., 245, 331-350.
37. Schulte,F., and Ciriacy,M. (1995) HTR1/MTH1 encodes a represser for HXT genes. Yeast, 11, S239.
38. Sikorski,R.S. and Hieter,P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics, 122, 19-27.
39. Vallier,L.G., Coons,D., Bisson,L.F. and Carlson,M. (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics, 136, 1279-1285.
40. Yang,Z. and Bisson,L.F. (1996) The SKS1 protein kinase is a multicopy suppressor of the snf3 mutation of Saccharomyces cerevisiae. Yeast, 12, 1407-1419.
41. Yamamoto,K.R. (1995) Multilayered control of intracellular receptor function. Harvey Lect., 91, 1-19.
42. Yocum,R.R., Hanley,S., West,J.R. and Ptashne,M. (1984) Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter site in Saccharomyces cerevisiae. Mol. Cell. Biol., 4, 1985-1998.
43. Zenke,F.T., Engles,R., Vollenbroich,V., Meyer,J., Hollenberg,C.P. and Breunig,K.D. (1996) Activation of Gal4p by galactose-dependent interaction of galactokinase and Ga180p. Science, 272, 1662-1665.