Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants

Yeast

Volumn 18, Issue 14, 2001, Pages 1309-1316

  Mayordomo, Isabel ^a   Sanz, Pascual ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Glucose induction; Glucose repression; Glucose signalling; Hexokinase PII; Human pancreas glucokinase; Yeast

Indexed keywords

GLC7 PHOSPHOPROTEIN PHOSPHATASE; GLUCOKINASE; GLUCOSE; HEXOKINASE; HEXOKINASE PII; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; RECOMBINANT PROTEIN; REG1 PHOSPHOPROTEIN PHOSPHATASE; SNF1 PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME KINETICS; GENETIC COMPLEMENTATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

GENE EXPRESSION REGULATION; GLUCOKINASE; GLUCOSE; HEXOKINASE; HUMANS; MUTATION; PANCREAS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 0034772470     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/yea.780     Document Type: Article

References (34)

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
2. Glucose repression in yeast
3. Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B
4. Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis
5. The pancreatic β-cell glucose sensor
6. Genetic evidence for a role of hexokinase isozyme PH in carbon catabolite repression in Saccharomyces cerevisiae
7. Yeast carbon catabolite repression
8. Glucokinase mutations associated with non-insulin-dependent (type2) diabetes mellitus have decreased enzymatic activity: Implications for structure/function relationships
9. New yeast Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
10. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
11. Glucose regulates protein interactions within the yeast SNF1 protein kinase complex
12. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
13. Variable effects of maturity-onset-diabetes-of -youth (MODY) associated glucokinase mutations on substrate interactions and stability of the enzyme
14. Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae
15. The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae
16. Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression
17. Alternative promoter in the glucokinase gene is active in the pancreatic β-cell
18. Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes
19. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
20. Pancreatic β-cell glucokinase: Closing the gap between theoretical concepts and experimental realities
21. Glucokinase as pancreatic β-cell glucose sensor and diabetes gene
22. Metabolic coupling factors in pancreatic β-cell signal transduction
23. Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose
24. Signal transduction mechanisms in nutrient induced insulin secretion
25. Construction of baker's yeast strains that secrete Aspergillus ozyzae alpha-amylase and their use in bread making
26. Glucose repression in Saccharomyces cerevisiae is directly associated with hexose phosphorylation by hexokinase PI and PH
27. Malonyl-CoA, fuel sensing and insulin resistance
28. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β-cells, and may regulate insulin release
29. Regulatory interactions between the Reg1 Glc7 protein phosphatase and the Snf1 protein kinase
30. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
31. Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1
32. Binding of nucleoside triphosphates, inorganic phosphate, and other polyanionic ligands to the N-terminal region of rat brain hexokinase: Relationship to regulation of hexokinase activity by antagonistic glucose-6 phosphate and inorganic phosphate