Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1

EMBO Journal

Volumn 17, Issue 19, 1998, Pages 5757-5765

  Song, Wenjie ^a   Carlson, Marian ^a  

^a Columbia University ^*  (United States)

Author keywords

Mediator; Saccharomyces cerevisiae; Srb; SUC2; Transcriptional repression

Indexed keywords

DNA; REGULATOR PROTEIN; REPRESSOR PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE DOSAGE; GENE MUTATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SACCHAROMYCES CEREVISIAE; TATA BOX; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BETA-FRUCTOFURANOSIDASE; BINDING SITES; CYCLIN-DEPENDENT KINASES; FUNGAL PROTEINS; GENE DOSAGE; GENE EXPRESSION REGULATION, FUNGAL; GENES, REPORTER; GLYCOSIDE HYDROLASES; MODELS, GENETIC; MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE ENDOPEPTIDASES; TATA BOX; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES CEREVISIAE;

EID: 0032190165     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.19.5757     Document Type: Article

References (62)

1. Balciunas, D. and Ronne, H. (1995) Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Nucleic Acids Res., 23, 4421-1425.
2. Barberis, A., Pearlberg, J., Simkovich, N., Farrell, S., Reinagel, P., Bamdad, C., Sigal, G. and Ptashne, M. (1995) Contact with a component of the polymerase II holoenzyme suffices for gene activation. Cell, 81, 359-368.
3. Carlson, M. (1997) Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD. Annu. Rev. Cell. Dev. Biol., 13, 1-23.
4. Carlson, M., Osmond, B.C., Neigeborn, L. and Botstein, D. (1984) A suppressor of snf1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics, 107, 19-32.
5. Chao, D.M., Gadbois, E.L., Murray, P.J., Anderson, S.F., Sonu, M.S., Parvin, J.D. and Young, R.A. (1996) A mammalian SRB protein associated with an RNA polymerase II holoenzyme. Nature, 380, 82-85.
6. Chen, S., West, R.W., Johnson, S.L., Gans, H., Kruger, B. and Ma, J. (1993) TSR3, a global regulatory protein that silences transcription of yeast GAL genes, also mediates repression by α2 repressor and is identical to SIN4. Mol. Cell. Biol., 13, 831-840.
7. Cooper, J.P., Roth, S.Y. and Simpson, R.T. (1994) The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev., 8, 1400-1410.
8. Covitz, P.A., Song, W. and Mitchell, A.P. (1994) Requirement tor RGR1 and SIN4 in RME1-dependent repression in Saccharomyces cerevisiae. Genetics, 138, 577-586.
9. Edmondson, D.G., Smith, M.M. and Roth, S.Y. (1996) Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev., 10, 1247-1259.
10. Farrell, S., Simkovich, N., Wu, Y., Barberis, A. and Ptashne, M. (1996) Gene activation by recruitment of the RNA polymerase II holoenzyme. Genes Dev., 10, 1359-2367.
11. Fujita, A., Kikuchi, Y., Kuhara, S., Misumi, Y., Matsumoto, S. and Kobayashi, H. (1989) Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or yeast heat-shock transcription factor. Gene, 85, 321-328.
12. Greenblatt, J. (1997) RNA polymerase II holoenzyme and transcriptional regulation. Curr. Opin. Cell Biol., 9, 310-319.
13. Guarente, L. (1983) Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. Methods Enzymol., 101, 181-191.
14. Guarente, L. and Hoar, E. (1984) Upstream activation sites ot the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the 'TATA box'. Proc. Natl Acad. Sci. USA, 81, 7860-7864.
15. Gustafsson, C.M., Myers, L.C., Yang, L., Redd, M.J., Lui, M., Erdjument-Bromage, H., Tempst, P. and Kornberg, R.D. (1997) Identification of Rox3 as a component of mediator and RNA polymerase II holoenzyme. J. Biol. Chem., 272, 48-50.
16. Hanes, S.D. and Brent, R. (1989) DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell, 57, 1275-1283.
17. Hanna-Rose, W. and Hansen, U. (1996) Active repression mediated by eukarvotic factors: molecular targets and potential mechanisms. Trends Genet., 12, 229-234.
18. Hengartner, C.J., Thompson, C.M., Zhang, J., Chao, D.M., Liao, S.-M., Koleske, A.J., Okamura, S. and Young, R.A. (1995) Association of an activator with an RNA polymerase II holoenzyme. Genes Dev., 9, 897-910.
19. Himmelfarb, H.J., Pearlberg, J., Last, D.H. and Ptashne, M. (1990) GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators. Cell, 63, 1299-1309.
20. Jiang, Y.W. and Stillman, D.J. (1992) Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae. Mol. Cell. Biol., 12, 4503-4514.
21. Johnson, A.D. (1995) The price of repression. Cell, 81, 655-658.
22. Keleher, C.A., Redd, M.J., Schultz, J., Carlson, M. and Johnson, A.D. (1992) Ssn6-Tup1 is a general repressor of transcription in yeast. Cell, 68, 709-719.
23. Kim, Y.-J., Bjorklund, S., Li, Y., Sayre, M.H. and Kornberg, R.D. (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell, 77, 599-608.
24. Koleske, A.J. and Young, R.A. (1994) An RNA polymerase II holoenzyme responsive to activators. Nature, 368, 466-469.
25. Kuchin, S. and Carlson, M. (1998) Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I and transcriptional corepressor Ssn6-Tup1. Mol. Cell. Biol., 18, 1163-1171.
26. Kuchin, S., Yeghiayan, P. and Carlson, M. (1995) Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast. Proc. Natl Acad. Sci. USA, 92, 4006-4010.
27. Laurent, B.C. and Carlson, M. (1992) Yeast SNF2/SWI2, SNF5 and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid. Genes Dev., 6, 1707-1715.
28. Legrain, P., Dokhelar, M.-C. and Transy, C. (1994) Detection of protein-protein interactions using different vectors in the two-hybrid system. Nucleic Acids Res., 22, 3241-3242.
29. Li, Y., Bjorklund, S., Jiang, Y.W., Kim, Y.-J., Lane, W.S., Stillman, D.J. and Kornberg, R.D. (1995) Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proc. Natl Acad. Sci. USA, 92, 10864-10868.
30. Liao, S.-M., Zhang, J., Jeffery, D.A., Koleske, A.J., Thompson, C.M., Chao, D.M., Viljoen, M., van Vuuren, H.J.J. and Young, R.A. (1995) A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature, 374, 193-196.
31. Lutfiyya, L.L. and Johnston, M. (1996) Two zinc-finger-containing repressors are responsible for glucose repression of SUC2 expression. Mol. Cell. Biol., 16, 4790-4797.
32. Maldonado, E. et al. (1996) A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature, 381, 86-89.
33. Myers, L., Gustafsson, C., Bushnell, D., Lui, M., Erdjument-Bromage, H., Tempst, P. and Kornberg, R. (1998) The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev., 12, 45-54.
34. Nehlin, J.O. and Ronne, H. (1990) Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J., 9, 2891-2898.
35. Neish, A., Anderson, S., Schlegel, B., Wei, W. and Parvin, J. (1998) Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res., 26, 847-853.
36. Nonet, M.L. and Young, R.A. (1989) Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics, 123, 715-724.
37. Ossipow, V., Tassan, J., Nigg, E. and Schibler, U. (1995) A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Cell, 83, 137-146.
38. Ozcan, S., Vallier, L.G., Flick, J.S., Carlson, M. and Johnston, M. (1997) Expression of the SUC2 gene of Saccharomyces cerevisiae is induced by low levels of glucose. Yeast, 13, 127-137.
39. Pan, G., Aso, T. and Greenblatt, J. (1997) Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators. J. Biol. Chem., 272, 24563-24571.
40. Piruat, J.I., Chavez, S. and Aguilera, A. (1997) The yeast HRS1 gene is involved in positive and negative regulation of transcription and shows genetic characteristics similar to SIN4 and GAL11. Genetics, 147, 1585-1594.
41. Rose, M.D., Novick, P., Thomas, J.H., Botstein, D. and Fink, G.R. (1987) A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene, 60, 237-243.
42. Rose, M.D., Winston, F. and Hieter, P. (1990) Methods in Yeast Genetics, a Laboratory Course Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
43. Rosenblum-Vos, L.S., Rhodes, L., Evangelista, J.C.C., Boayke, K.A. and Zitomer, R.S. (1991) The ROX3 gene encodes an essential nuclear protein involved in CYC7 gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol., 11, 5639-5647.
44. Roth, S.Y. (1995) Chromatin-mediated transcriptional repression in yeast. Curr. Opin. Gen. Dev., 5, 168-173.
45. Sakai, A., Shimizu, Y., Kondou, S., Chibazakura, T. and Hishinuma, F. (1990) Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae. Mol. Cell. Biol., 10, 4130-4138.
46. Sarokin, L. and Carlson, M. (1984) Upstream region required for regulated expression of the glucose-repressible SUC2 gene of Saccharomyces cerevisiae. Mol. Cell. Biol., 4, 2750-2757.
47. Sarokin, L. and Carlson, M. (1985) Upstream region of the SUC2 gene confers regulated expression to a heterologous gene in Saccharomyces cerevisiae. Mol. Cell. Biol., 5, 2521-2526.
48. Sarokin, L. and Carlson, M. (1986) Short repeated elements in the upstream regulatory region of the SUC2 gene of Saccharomyces cerevisiae. Mol. Cell Biol., 6, 2324-2333.
49. Schultz, J. and Carlson, M. (1987) Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae. Mol. Cell. Biol., 7, 3637-3645.
50. Shimizu, M., Li, W., Shindo, H. and Mitchell, A. (1997) Transcriptional repression at a distance through exclusion of activator binding in vivo. Proc. Natl Acad. Sci. USA, 94, 790-795.
51. Song, W., Treich, I., Qian, N., Kuchin, S. and Carlson, M. (1996) SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3 and SRB proteins associated with RNA polymerase II. Mol. Cell. Biol., 16, 115-120.
52. Sorger, P.K. and Nelson, H.C.M. (1989) Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell, 59, 807-813.
53. Sternberg, P.W., Stern, M.J., Clark, I. and Herskowitz, I. (1987) Activation of the yeast HO gene by release from multiple negative controls. Cell, 48, 567-577.
54. Stillman, D.J., Dorland, S. and Yu.Y. (1994) Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics, 136, 781-788.
55. Surosky, R.T., Strich, R. and Esposito, R.E. (1994) The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose. Mol. Cell. Biol., 14, 3446-3458.
56. Thompson, C.M., Koleske, A.J., Chao, D.M. and Young, R.A. (1993) A multisubunit complex associated with the RNA polymerase CTD and TATA-binding protein in yeast. Cell, 73, 1361-1375.
57. Treitel, M.A. and Carlson, M. (1995) Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc. Natl Acad. Sci. USA, 92, 3132-3136.
58. Tzamarias, D. and Struhl, K. (1995) Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev., 9, 821-831.
59. Vallier, L.G. and Carlson, M. (1994) Synergistic release from glucose repression by mig1 and ssn mutations in Sacchammyces cerevisiae. Genetics, 137, 49-54.
60. Wahi, M. and Johnson, A.D. (1995) Identification of genes required for α2 repression in Saccharomyces cerevisiae. Genetics, 140, 79-90.
61. Williams, F.E., Varanasi, U. and Trumbly, R.J. (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol. Cell. Biol., 11, 3307-3316.
62. Yang, X., Hubbard, E.J.A. and Carlson, M. (1992) A protein kinase substrate identified by the two-hybrid system. Science, 257, 680-682.