Titration of non-replicating adenovirus as a vector for transducing active TGF-beta;1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice

International Journal of Experimental Pathology

Volumn 83, Issue 4, 2002, Pages 183-202

  Warshamana, G Sakuntala ^a   Pociask, Derek A ^a   Fisher, Krishna J ^a   Liu, Jing Yao ^a   Sime, Patricia J ^b   Brody, Arnold R ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Adenovirus vector; Cell proliferation; Collagen; Fibrogenesis; Lung inflammation; Pro 1 (I); TGF 1 gene expression

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN; COLLAGEN TYPE 1; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DISEASE MODEL; DISEASE SEVERITY; EPITHELIUM CELL; FIBROGENESIS; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; GROWTH INHIBITION; INFLAMMATION; INFLAMMATORY CELL; KNOCKOUT MOUSE; LUNG PARENCHYMA; MALE; MEDIATOR; MOUSE; MOUSE STRAIN; NONHUMAN; PARAMETER; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY EPITHELIUM; SWINE; TITRIMETRY; VIRUS RECOMBINANT; VIRUS REPLICATION;

EID: 0036902130     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2002.00229.x     Document Type: Article

References (83)

1. Adamson I.Y. (1984) Drug-induced pulmonary fibrosis. Environ. Health Perspect. 55, 25-36.
2. Adler K.B., Fischer B.M., Wright D.T., Cohn L.A. & Becker S. (1994) Interactions between respiratory epithelial cells and cytokines: Relationships to lung inflammation. Ann. NY Acad. Sci. 725, 128-145.
3. Antoniades H.N., Bravo M.A., Avila R.E. et al. (1990) Platelet-derived growth factor in idiopathic pulmonary fibrosis. J. Clin. Invest. 86, 1055-1064.
4. Ausubel F.M., Brent R., Kingston R.E. et al. (1994) Current Protocols in Molecular Biology. New York: John Wiley and Sons.
5. Bachwich P.R., Lynch J.P., 3rd, Larrick J., Spengler M. & Kunkel S.L. (1986) Tumor necrosis factor production by human sarcoid alveolar macrophages. Am. J. Pathol. 125, 421-425.
6. Battegay E.J., Raines E.W., Seifert R.A., Bowen-Pope D.F. & Ross R. (1990) TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 63, 515-524.
7. Baughman R.P., Lower E.E., Miller M.A., Bejarano P.A. & Heffelfinger S.C. (1999) Overexpression of transforming growth factor-alpha and epidermal growth factor-receptor in idiopathic pulmonary fibrosis. Sarcoidosis Vasc. Diffuse Lung Dis. 16, 57-61.
8. Benihoud K., Yeh P. & Perricaudet M. (1999) Adenovirus vectors for gene therapy. Curr. Opin. Biotechnol. 10, 440-447.
9. Berg R.A. (1982) Determination of 3- and 4-Hydroxyproline. Meth. Enzymol. 82, 372-380.
10. Bonner J., Goodell A., Coin P. & Brody A. (1993) Chrysotile asbestos upregulates gene expression and production of alpha receptors for PDGF AA on RLFs. J. Clin. Invest. 92, 425-430.
11. Border W.A. & Noble N.A. (1994) TGFβ in tissue fibrosis. N. Engl. J. Med. 331, 1286-1292.
12. Brass D.M., Hoyle G.W., Poovey H.G., Liu J.-Y. & Brody A.R. (1999) Reduced tumor necrosis factor-α and transforming growth factor-β1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure. Am. J. Pathol. 154, 853-862.
13. Bristol J.A. & Connelly S. (2000) In vivo dose threshold effect of adenovirus-mediated factor VIII gene therapy in hemophilic mice. Mol. Ther. 2, 223-232.
14. Brody A.R. (1997) Occupational lung disease and the role of peptide growth factors. Curr. Opin. Pulm Med. 3, 203-208.
15. Brody A.R. (2000) Inhalation of asbestos fibers and consequent expression of peptide growth factors. Inhal. Toxicol. 12, 245-250.
16. Broekelmann T.J., Limper A.H., Colby T.V. & McDonald J.A. (1991) Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Nat. Acad. Sci. USA 88, 6642-6646.
17. Cazals V., Mouhieddine B., Maitre B. et al. (1994) Insulin-like growth factors, their binding proteins, and transforming growth factor-beta 1 in oxidant-arrested lung alveolar epithelial cells. J. Biol. Chem. 269, 14111-14117.
18. Chao C.C., Hu S., Sheng W.S., Tsang M. & Peterson P.K. (1995) Tumor necrosis factor-α mediates the release of bioactive transforming growth factor-β in murine microglial cell cultures. Clin. Immunol. Immunopath. 77, 358-365.
19. Chomczynski P. & Sacchi N. (1987) Single step method of RNA isolation by acid guanidiniuim thiocyanate-phenolchloroform extraction. Analyt. Biochem. 162, 156-159.
20. Curiel D.T., Pilewski J.M. & Albelda S.M. (1996) Gene therapy approaches for inherited and acquired lung diseases. Am. J. Respir. Cell Mol. Biol. 14, 1-18.
21. Dixon D., Bowser A.D., Badgett A., Haseman J.K. & Brody A.R. (1995) Incorporation of bromodeoxyuridine (BrdU) in the bronchiolar-alveolar regions of the lungs following two inhalation exposures to chrysotile asbestos in strain A/J mice. J. Environ. Pathol. Toxicol. Oncol. 14, 205-213.
22. Elias J.A., Freundlich B., Kern J.A. & Rosenbloom J. (1990) Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest 97, 1439-1445.
23. Fallaux F.J., Kranenburg O., Cramer S.J. et al. (1996) Characterization of 911: A new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum. Gene Ther. 7, 215-222.
24. Fine A. & Goldstein R.H. (1987) The effect of transforming growth factor-β on cell proliferation and collagen formation by lung fibroblasts. J. Biol. Chem. 262, 3897-3902.
25. Gardner S.Y. & Brody A.R. (1995) Incorporation of bromodeoxyuridine as a method to quantify cell proliferation in bronchiolar-alveolar duct regions of asbestos-exposed mice. Inhal. Toxicol. 7, 215-224.
26. Garrigue-Antar L., Barbieux I., Lieubeau B., Boisteau O. & Gregoire M. (1995) Optimisation of CCL64-based bioassay for TGF-beta. J. Immunol. Meth. 186, 267-274.
27. Gleizes P.E., Munger J.S., Nunes I. et al. (1997) TGF-beta latency: Biological significance and mechanisms of activation. Stem Cells 15, 190-197.
28. Gomori G. (1950) Gomori's one-step trichrome method. Am. J. Clin. Path. 20, 661-664.
29. Graham F.L. & Prevec L. (1995) Methods for construction of adenovirus vectors - Protocol. Mol. Biotechnol. 3, 207-220.
30. Green M. & Pina M. (1963) Biochemical studies on adenovirus multiplication. IV. Isolation, purification and chemical analysis of adenovirus. Virology 20, 199-207.
31. Harrod K. & Whitsett J. (1999) SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection. Am. J. Physiol. 277, L580-L588.
32. Ignotz R.A. & Massague J. (1986) Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261, 4337-4345.
33. Kelley J. (1993) Transforming growth factor-β. In Cytokines of the Lung. Ed. J. Kelley. New York: Marcel Dekker Inc, pp. 101-137.
34. Kelley J., Fabisiak J.P., Hawes K. & Absher M. (1991) Cytokine signaling in lung: Transforming growth factor-beta secretion by lung fibroblasts. Am. J. Physiol. 260, L123-L128.
35. Khalil N. & Greenberg A.H. (1991) The role of TGF-beta in pulmonary fibrosis. Ciba Found. Symp. 157, 194-207.
36. Khalil N., O'Connor R.N., Unruh H.W., Warren P.W., Flanders K.C., Kemp A., Bereznay O.H. & Greenberg A.H. (1991b) Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 5, 155-162.
37. Khalil N., O'Connor R., Unruh H., Warren P., Kemp A. & Greenberg A. (1991a) Enhanced expression and immunohistochemical distribution of transforming growth factor-beta in idiopathic pulmonary fibrosis. Chest 99, 65S-66S.
38. Kolb M., Margetts P.J., Anthony D.C., Pitossi F. & Gauldie J. (2001) Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J. Clin. Invest. 107, 1529-1536.
39. Kolls J., Peppel K., Silva M. & Beutler B. (1994) Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc. Nat. Acad. Sci. USA 91, 215-219.
40. Korfhagen T.R., Swantz R.J., Wert S.E. et al. (1994) Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. J. Clin. Invest. 93, 1691-1699.
41. Lasky J.A., Coin P.G., Lindroos P.M., Ostrowski L.E., Brody A.R. & Bonner J.C. (1995) Chrysotile asbestos stimulates PDGF-AA production by rat lung fibroblasts in vitro: Evidence for an autocrine loop. Am. J. Respir. Cell Mol. Biol. 12, 162-170.
42. Lasky J.A., Tonthat B., Liu J.Y., Friedman M. & Brody A.R. (1998) Upregulation of the PDGFα receptor precedes asbestos-induced lung fibrosis in rats. Am. J. Respir. Crit. Care Med. 157, 1652-1657.
43. Leof E.B., Proper J.A., Goustin A.S., Shipley G.D., Dicorleto P.E. & Moses H.L. (1986) Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: A proposed model for indirect mitogenesis involving autocrine activity. Proc. Nat. Acad. Sci. USA 83, 2453-2457.
44. Limper A.H., Broekelmann T.J., Colby T.V., Malizia G. & McDonald J.A. (1991) Analysis of local mRNA expression for extracellular matrix proteins and growth factors using in situ hybridization in fibroproliferative lung disorders. Chest 99, 55S-56S.
45. Liu J.-Y., Brass D.M., Hoyle G.W. & Brody A.R. (1998) TNFα receptor knock out mice are protected from the fibroproliferative effects of inhaled asbestos fibers. Am. J. Pathol. 153, 1839-1847.
46. Liu J.-Y. & Brody A.R. (2001) Increased TGFβ1 in the lungs of asbestos-exposed rats and mice: Reduced expression in TNFα receptor knockout mice. J. Environ. Pathol. Toxicol. Oncol. 20, 77-87.
47. Liu J.Y., Morris G.F., Lei W.H., Corti M. & Brody A.R. (1996) Up-regulated expression of TGFα in the bronchiolar-alveolar duct regions of asbestos-exposed rats. Am. J. Pathol 149, 205-217.
48. Liu J.-Y., Morris G.F., Lei W.H., Hart C.E., Lasky J.A. & Brody A.R. (1997) Rapid activation of PDGF A and B expression at sites of lung injury in asbestos-exposed rats. Am. J. Respir. Cell Mol. Biol. 17, 129-140.
49. 1 overexpression in tumor necrosis factor-α receptor knockout mice induces fibroproliferative lung disease. Am. J. Respir. Cell Mol. Biol. 25, 3-7.
50. Martinet Y., Rom W.N., Grotendorst G.R., Martin G.R. & Crystal R.G. (1987) Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 317, 202-209.
51. McCartney-Francis N., Mizel D., Wong H., Wahl L. & Wahl S. (1990) TGF-beta regulates production of growth factors and TGF-beta by human peripheral blood monocytes. Growth Factors 4, 27-35.
52. Morikawa O., Walker T.A., Nielsen L.D., Pan T., Cook J.L. & Mason R.J. (2000) Effect of adenovector-mediated gene transfer of keratinocyte growth factor (KGF) on the proliferation of alveolar type II cells in vitro and in vivo. Am. J. Respir. Cell Mol. Biol. 23, 626-635.
53. Munger J.S., Harpel J.G., Gleizes P.E., Mazzieri R., Nunes I. & Rifkin D.B. (1997) Latent transforming growth factor-beta: Structural features and mechanisms of activation. Kidney Int. 51, 1376-1382.
54. Ortiz L.A., Lasky J., Lungarella G. et al. (1999) Upregulation of the p75 but not the p55 TNF-α receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice. Am. J. Respir. Cell Mol. Biol. 20, 825-833.
55. Paulsson Y., Austgulen R., Hofsli E., Heldin C.H., Westermark B. & Nissen-Meyer J. (1989) Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts. Exp. Cell Res. 180, 490-496.
56. Perdue T.D. & Brody A.R. (1994) Distribution of TGF β1, fibronectin and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats. J. Histochem. Cytochem. 42, 1061-1070.
57. Phan S.H. (1989) Diffuse interstitial fibrosis. In Lung Cell Biology (Series Title: Lung Biology in Health and Disease), Vol. 41. Ed. D. Massaro. New York: Marcel Dekker Inc, pp. 907-980.
58. Phan S.H., Gharaee-Kermani M., McGarry B., Kunkel S.L. & Wolber F.W. (1992) Regulation of rat pulmonary artery endothelial cell transforming growth factor beta 1 production by IL-1β and tumor necrosis factor α. J. Immunol. 149, 103-106.
59. Piguet P.F. (1993) Cytokines involved in pulmonary fibrosis. Int. Rev. Exp. Path. 34B, 173-181.
60. Piguet P.F., Collart M.A., Grau G.E., Kapanci Y. & Vassalli P. (1989) Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170, 655-663.
61. Piguet P.F., Collart M.A., Grau G.E., Sappino A.P. & Vassalli P. (1990) Requirement of TNF for development of silica-induced pulmonary fibrosis. Nature 344, 245-247.
62. Piguet P.F., Grau G.E. & Vassalli P. (1991) Tumor necrosis factor and immunopathology. Immunol. Res. 10, 122-140.
63. Raines E.W., Dower S.K. & Ross R. (1989) Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science 243, 393-396.
64. Roberts A.B., Anzano M.A., Wakefield L.M., Roche N.S., Stern D.F. & Sporn M.B. (1985) Type beta transforming growth factor: A bifunctional regulator of cellular growth. Proc. Nat. Acad. Sci. USA 82, 119-123.
65. Ross R., Haines E. & Bowen-Pope D. (1986) The biology of PDGF - Review. Cell 46, 155-169.
66. Rossi P., Karsenty G., Roberts A.B., Roche N.S., Sporn M.B. & De Crombrugghe B. (1988) A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell 52, 405-414.
67. Sambrook J., Fritsch E.F. & Maniatis T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
68. Schiedner G., Morral N., Parks R.J. et al. (1998) Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nature Genet. 18, 180-183.
69. Sherry B. & Cerami A. (1988) Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses. J. Cell Biol. 107, 1269-1277.
70. Sikic B.I., Young D.M., Mimnaugh E.G. & Gram T.E. (1978) Quantification of bleomycin pulmonary toxicity in mice by changes in lung hydroxyproline content and morphometric histopathology. Cancer Res. 38, 787-792.
71. Sime P.J., Marr R.A., Gauldie D. et al. (1998) Transfer of TNFα to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of TGFb1 and myofibroblasts. Am. J. Pathol. 153, 825-832.
72. Sime P.J., Xing Z., Graham F.L., Csaky K.G. & Gauldie J. (1997) Adenovector-mediated gene transfer of active transforming growth factor β1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 100, 768-776.
73. Soma Y. & Grotendorst G.R. (1989) TGF-beta stimulates primary human skin fibroblast DNA synthesis via an autocrine production of PDGF-related peptides. J. Cell Physiol. 140, 246-253.
74. Warshamana G.S., Corti M. & Brody A.R. (2001) TNF-α, PDGF and TGF-β1 expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: TNF-α induces TGF-β1. Exp. Mol. Pathol. 71, 13-33.
75. Wickham T.J. (2000) Targeting adenovirus - Review. Gene Ther. 7, 110-114.
76. Woessner J.F. Jr (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93, 440-447.
77. Xing Z., Ohkawara Y., Jordana M., Graham F. & Gauldie J. (1996) Transfer of GM CSF gene to rat lung induces eosinophilia, monocytosis and fibrotic reactions. J. Clin. Invest. 97, 1102-1110.
78. Yang Y., Li Q., Ertl H.C. & Wilson J.M. (1995) Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015.
79. Yang Y., Su Q. & Wilson J.M. (1996) Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J. Virol. 70, 7209-7212.
80. Zhang K., Gharaee-Kermani M., McGarry B., Remick D. & Phan S.H. (1997) TNFα mediated lung cytokine networking and eosinophil recruitment in pulmonary fibrosis. J. Immunol. 158, 954-959.
81. Zhang Y., Lee T.C., Guillemin B., Yu, M.C. & Rom W.N. (1993) Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J. Immunol. 150, 4188-4196.
82. Zhang K. & Phan S.H. (1996) Cytokines and pulmonary fibrosis. Biol. Signals 5, 232-239.
83. Zhao J., Sime P.J., Bringas P. Jr et al. (1999) Spatial-specific TGFβ1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung. Eur. J. Cell Biol. 78, 715-725.