Upregulation of the PDCF-alpha receptor precedes asbestos-induced lung fibrosis in rats

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 5 PART I, 1998, Pages 1652-1657

  Lasky, Joseph A ^a,b   Tonthat, Boihoang ^a   Liu, Jing Yao ^a   Friedman, Mitchell ^a   Brody, Arnold R ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL TISSUE; ARTICLE; ASBESTOSIS; LUNG ALVEOLUS MACROPHAGE; LUNG FIBROSIS; MALE; NONHUMAN; OCCUPATIONAL EXPOSURE; PATHOGENESIS; PRIORITY JOURNAL; RAT;

EID: 0031745629     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.5.9704116     Document Type: Article

References (15)

1. Ross, R., J. A. Glomset, B. Kariya, and L. Harker. 1974. A platelet-derived serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. U.S.A. 71:1207-1210.
2. Brody, A. R., J. C. Bonner, L. H. Overby, A. Badgett, V. Kalter, R. K. Kumar, and R. A. Bennett. 1992. Intersitital pulmonary macrophages produce platelet-derived growth factor that stimulates rat lung fibroblast proliferation m vitro. J. Leukoc. Biol. 51:640-648.
3. Fabisiak, J. P., M. Abscher, J. N. Evans, and J. Kelley. 1992. Spontaneous production of PDGF-A chain homodimer by rat lung fibroblasts in vitro. Am. J. Physiol. 263:L185-L193.
4. Sporn, M. B., and A. R. Roberts. 1991. Peptide Growth Factors and Their Receptors. Springer-Verlag, New York.
5. Antoniades, H. N., M. A. Bravo, R. E. Avila, T. Galanopoulos, J. Neville-Golden, and M. Selman. 1990. Platelet-derived growth factor in idiopathic pulmonary fibrosis. J. Clin. Invest. 86:1055-1064.
6. Heldin, C.-H., and B. Westermark. 1990. Signal transduction by the receptors for platelet-derived growth factor. Science 96:193-196.
7. Osornio-Vargas, A. R., A. L. Goodell, N. A. Hernadez-Rodriquez, A. R. Brody, P. G. Coin, A. Badget, and J. C. Bonner. 1995. Platelet-derived growth factor (PDGF)-AA, -AB, and -BB induce differential chemotaxis of early-passage rat lung fibroblasts in vitro. Am. J. Respir. Cell Mol. Biol. 12:33-40.
8. Ferns, G. A. A., E. W. Raines, K. H. Sprugel, A. S. Motani, M. A. Reidy, and R. Ross. 1991. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 253:1129-1132.
9. Johnson, R. J., E. W. Raines, J. Floege, A. Yoshimura, P. Pritzl, C. Alpers, and R. Ross. 1992. Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp. Med. 175:1413-1416.
10. Raines, E. W., S. K. Dower, and R. Ross. 1989. Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science 243:393-395.
11. Battegay, E. J., E. W. Raines, R. A. Seifert, D. F. Bowen-Pope, and R. Ross. 1990. TGF-beta induces biomodal proliferation of connective tissue cells via complex control of an autocrine PDGF-loop. Cell 63:515-524.
12. Okazaki, H., M. W. Majesky, L. A. Harker, and S. M. Schwartz. 1992. Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells. Circ. Res. 71:1285-1293.
13. Brody, A. R., L. H. Hill, B. Adkins, and W. O'Connor. 1981. Chrysolite asbestos inhalation in rats: deposition pattern and reaction of alveolar epithelium and pulmonary macrophages. Am. Rev. Respir. Dis. 123:670-679.
14. Chang, L.-Y., L. H. Overby, A. R. Brody, and J. D. Crapo. 1988. Progressive lung cell reactions and extracelular matrix production after a brief exposure to asbestos. Am. J. Pathol. 131:156-170.
15. Brody, A. R., and L. H. Overby. 1989. Incorporation of tritiated thymidine by epithelial and interstitial cells in bronchiolar-alveolar regions of asbestos-exposed rats. Am. J. Pathol. 134:133-140.