Occupational lung disease and the role of peptide growth factors

Current Opinion in Pulmonary Medicine

Volumn 3, Issue 3, 1997, Pages 203-208

  Brody, Arnold R ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL; HUMAN; LUNG DISEASE; MOUSE; OCCUPATIONAL DISEASE; PHYSIOLOGY; RAT; REVIEW;

ANIMALS; HUMANS; LUNG DISEASES; MICE; OCCUPATIONAL DISEASES; PLATELET-DERIVED GROWTH FACTOR; RATS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0031137232     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/00063198-199705000-00004     Document Type: Article

References (37)

1. Rom WN: Environmental and Occupational Medicine, edn 2. Boston: Little Brown and Company; 1992.
2. Crouch E: Pathobiology of pulmonary fibrosis. Am J Physiol 1990, 259:L159-L184.
3. Mannino DM, Etzel RA, Parrish RG: Pulmonary fibrosis deaths in the United States, 1979-1991: an analysis of multiple-cause mortality data. Am J Respir Crit Care Med 1996, 153:1548-1552. The incidence of interstitial pulmonary fibrosis of multiple etiologies increased in a 12-year period: 1979-1991.
4. Yi ES, Lee H, Yin S, Piguet P, Sarosi I, Kaufmann S, Tarpley J, Wang N-S, Ulich TR: Platelet-derived growth factor causes pulmonary cell proliferation and collagen deposition in vivo. Am J Pathol 1996, 149:539-548. Instillation of human PDGF-BB down the airways of rats induces mesenchymal cell growth and peribronchiolar fibrosis.
5. Liu J-Y, Morris GF, Lei W-H, Corti M, Brody AR: Up-regulated expression of transforming growth factor-α in the bronchiolar-alveolar duct regions of asbestos-exposed rats. Am J Pathol 1996, 149:205-217. Deposition of asbestos fibers at bronchiolar-alveolar duct junctions results in rapid upregulation of TGF-α gene expression and protein production, primarily within the epithelial cell populations.
6. Simonet WS, DeRose ML, Bucay N, Nguyen HQ, Wert SE, Zhou L, Ulich TR, Thomason A, Danilenko DM, Whitsett JA: Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. Proc Natl Acad Sci U S A 1995, 92:12461-12465. Keratinocyte growth factor is essential, at normal levels, for contolling proper rates of cell proliferation and lung development.
7. Khalil N, O'Connor RN, Flanders KC, Unruh H: TGF-β1, but not TGF-β2 or TGF-β3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol 1996, 14:131-138. TGF-β1 is the major growth factor controlling matrix deposition that is expressed in human lungs exhibiting interstitial pulmonary fibrosis.
8. Ross R, Raines EW, Bowen-Pope DF: The biology of platelet-derived growth factor. Cell 1986, 46:155-169.
9. Fretto U, Snape AJ, Tomlinson JE, Seroogy JJ, Wolf DL, LaRochelle WJ, Giese NA: Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to α and β PDGF receptor. J Biol Chem 1993, 268:3625-3631.
10. Seifert RA, Hart CE, Philips PE, Forstrom JW, Ross R, Murray M, Bowen-Pope DF: Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem 1989, 264:8771-8778.
11. Ross R, Masuda J, Raines EW, Gown AM, Katsuda S, Sasahara M, Malden LT, Masuko H, Sato H: Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science 1990, 248:1009-1012.
12. Bonner JC, Goodell AL, Coin PG, Brody AR: Chrysotile asbestos upregulates gene expression and production of α-receptors for platelet-derived growth factor (PDGF-AA) on rat lung fibroblasts. J Clin Invest 1993, 92:425-430.
13. 2-macroglobulin complex upregulate the platelet-derived growth factor α-receptor on rat pulmonary fibroblasts. Am J Respir Cell Mol Biol 1995, 13:455-465.
14. Coin PG, Lindroos PM, Bird G, Osornio-Vargas AR, Roggli VL, Bonner JC: Lipopolysaccharide upregulates platelet-derived growth factor (PDGF) α-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms. J Immunol 1996, 156:4797-4806. Lipopolysaccharide exhibits a direct effect on upregulation of PDGF α-receptor populations on primary lung myofibroblasts.
15. Bonner JC, Osornio-Vargas AR, Badgett A, Brody AR: Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor (PDGF) -AA, -AB, and -BB isoforms secreted by rat alveolar macrophages. Am J Respir Cell Mol Biol 1991, 5:539-547.
16. Shimokado K, Raines E, Madtes D, Barrett T, Benditt E, Ross R: A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. Cell 1985, 43:277-285.
17. Kumar RK, Bennett RA, Brody AR: A homologue of platelet-derived growth factor produced by rat alveolar macrophages. FASEB J 1988, 2:2272-2277.
18. Osornio-Vargas AR, Bonner JC, Badgett A, Brody AR: Rat alveolar macrophage-derived PDGF is chemotactic for rat lung fibroblasts. Am J Respir Cell Mol Biol 1990, 3:595-602.
19. Bonner JC, Brody AR: Cytokine-binding proteins in the lung. Am J Physiol 1995, 268:L869-L878.
20. Boström H, Willetts K, Pekny M, Levéen P, Lindahl P, Hedstrand H, Pekna M, Hellström M, Gebre-Medhin S, Schalling M, et al.: PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveo-genesis. Cell 1996, 85:863-873. Lack of PDGF-A expression causes reduced growth of lung myofibroblasts and consequent abnormalities of tissue development.
21. Lindner V, Reidy MA: Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo. Am J Pathol 1995, 146:1488-1497. PDGF-αR expression is upregulated in the vascular endothelium consequent to injury.
22. Schollmann C, Grugel R, Tatje D, Hoppe J, Folkman J, Marme D, Weich HA: Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF α-receptor in vascular smooth muscle cells. J Biol Chem 1992, 267:18032-18036.
23. Eriksson A, Nister M, Leveen P, Westermark B, Heldin CH, Claesson-Welsh L: Induction of platelet-derived growth factor α- and β-receptor mRNA and protein by platelet-derived growth factor BB. J Biol Chem 1991, 266:21138-21141.
24. Seifert RA, Coats SA, Raines EW, Ross R, Bowen-Pope DF: Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -independent pathways. J Biol Chem 1994, 269:13951-13957.
25. Bonner JC, Badgett A, Lindroos PM, Osornio-Varga AR: Transforming growth factor-β-1 (TGF-β-1) down-regulates the platelet-derived growth factor (PDGF) alpha-receptor subtype on human lung fibroblasts in vitro. Am J Respir Cell Mol Biol 1995, 13:496-503.
26. Lasky JA, Coin PC, Lindroos PM, Ostrowski LE, Brody AR, Bonner JC: Chrysotile asbestos stimulates gene expression and secretion of PDGF-AA by rat lung fibroblasts in vitro: evidence for an autocrine loop. Am J Respir Cell Mol Biol 1995, 12:162-170. Chrysotile asbestos upregulates expression of genes coding for both PDGF-AA and the PDGF-αR by lung fibroblasts, thus providing a mechanism for an "autocrine loop" for control of cell proliferation.
27. Liu J-Y, Morris G, Lei W-H, Hart C, Lasky J, Brody A: Rapid activation of PDGF-A and -B expression at sites of lung injury in asbestos exposed rats. Am J Respir Cell Moll Biol 1997, in press. PDGF-A and -B genes and proteins are expressed in epithelial and mesenchymal cell populations during a 5-hour exposure to chrysotile asbestos fibers.
28. Derynck R: The physiology of transforming growth factor-α. Adv Cancer Res 1992, 58:27-52.
29. Schreiber AB, Winkler ME, Derynck R: Transforming growth factor-α: a more potent angiogenic mediator than epidermal growth factor. Science 1986, 232:250-253. TGF-α shares the same membrane-bound receptor with epidermal growth factor and has proved to be a potent inducer of new vessel formation.
30. Yasui W, Zhong-Qiang J, Kuniyasu H, Ayhan A, Yokozaki H, Ito H, Tahara E: Expression of transforming growth factor-α in human tissues: immunohistochemical study and Northern blot analysis. Virchows Arch 1992, 421:513-519.
31. Korfhagen TR, Swantz RJ, Wert SE, McCarty JM, Kerlakian CB, Glasser SW, Whitsett JA: Respiratory epithelial cell expression of human transforming growth factor-α induces lung fibrosis in transgenic mice. J Clin Invest 1994, 93:1691-1699.
32. Madtes DK, Busky HK, Strandjord TP, Clark JG: Expression of transforming growth factor-α and epidermal growth factor receptor is increased following bleomycin-induced lung injury in rats. Am J Respir Cell Mol Biol 1994, 11:540-551.
33. Brain JD: Environmental lung disease: exposures and mechanisms. Chest 1996, 109:74-78. Scientists are just beginning to understand the molecular mechanisms through which exposures to toxic environmental agents cause disease.
34. Quinlan TR, BéruBé KA, Marsh JP, Janssen YMW, Taisi P, Leslie KO, Hemenway D, O'Shaughnessy PT, Vacek P, Mossman BT: Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos. Am J Pathol 1995, 147:729-739. Inhalation of asbestos causes raid upregulation of antioxidant molecules to protect the lung from injury.
35. Piguet PF, Collart MA, Grau GE, Sappino AP, Vassalli P: Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis. Nature 1990, 344:245-247.
36. Shin TH, Paterson AJ, Kudlow JE: p53 Stimulates transcription from the transforming growth factor alpha promoter: a potential growth-stimulatory role for p53. Mol Cell Biol 1995, 15:4694-4701.
37. Mishra A, Liu J-Y, Brody AR, Morris GF: Inhaled asbestos fibers induce p53 expression in the rat lung. Am J Respir Cell Mol Biol 1997, 16:479-485. p53, a protein essential for DNA repair and control of the cell cycle, is upregulated rapidly at sites of initial asbestos-induced lung injury.