Gene Therapy Approaches for Inherited and Acquired Lung Diseases

American Journal of Respiratory Cell and Molecular Biology

Volumn 14, Issue 1, 1996, Pages 1-18

  Curiel, David T ^a   Pilewski, Joseph M ^a   Albelda, Steven M ^a  

^a 440 Scaife Hall ^*

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; LUNG DISEASE; REVIEW; VIRUS;

ANIMALS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LUNG DISEASES; VIRUSES;

EID: 0029685022     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.14.1.8534480     Document Type: Review

References (211)

1. Anderson, W. F. 1984. Prospects for human gene therapy. Science 226: 401-409.
2. Anderson, W. F. 1992. Human gene therapy. Science 256:808-813.
3. Morgan, R. A., and W. F. Anderson. 1993. Human gene therapy. Annu. Rev. Biochem. 62:181-217.
4. Felgner, P. L., and G. Rhodes. 1991. Gene therapeutics. Nature 49: 351-352.
5. Miller, A. D. 1990. Progress toward human gene therapy. Blood 76: 271-278.
6. Cohen-Haguenauer, O. 1994. Transfer of genes, homologous recombination and genotherapy in hematology. Nouv. Rev. Fr. Hematol. 36(Suppl. I):S3-S9.
7. O'Malley, B. W., Jr., and F. D. Ledley. 1993. Somatic gene therapy: methods for the present and future. Arch. Otolaryngol. Head Neck Surg. 119:1100-1107.
8. Meager, A., and E. Griffiths. 1994. Human somatic gene therapy. Trends Biotechnol. 12:108-113.
9. Morsy, M. A., K. Mitani, P. Clemens, and C. T. Caskey. 1993. Progress toward human gene therapy. JAMA 280:2338-2345.
10. Roemer, K., and T. Friedmann. 1992. Concepts and strategies for human gene therapy. Eur. J. Biochem. 208:211-225.
11. Wolff, J. A., and J. Lederberg. 1994. An early history of gene transfer and therapy. Hum. Gene Ther. 5:469-480.
12. Gibaldi, M. 1993. Human gene therapy. Pharmacotherapy 13:79-87.
13. Luzzatto, L. 1992. Frontiers in medicine: gene transfer and gene therapy. J. Int. Med. 231:3-6.
14. Semayer, T. A., and W. K. Cavenee 1989. Biology of disease: molecular mechanisms of oncogenesis. Lab. Invest. 60:585-599.
15. de Lange, T. 1994. Activation of telomerase in a human tumor. Proc. Natl. Acad. Sci. USA 91:2882-2885.
16. Hall, A. 1994. A biochemical function for ras - at last. Science 264: 1413-1414.
17. Breo, D. L. 1994. The cancer revolution - from "black box" to "genetic disease." JAMA 271:1452-1454.
18. Marx, J. 1994. Oncogenes reach a milestone. Science 266:1942-1944.
19. Hartwell, L. H., and M. B. Kastan. 1994. Cell cycle control and cancer. Science 266:1821-1828.
20. Sobol, R. E., and K. J. Scanlon. 1995. Clinical protocols. Cancer Gene Therapy 2:137-145.
21. Cancer Statistics 1995 - A Cancer Journal for Clinicians, vol. 45.
22. Kotani, H., P. B. Newton, III, S. Zhang, Y. L. Chiang, E. Otto, L. Weaver, R. M. Blaese, W. F. Anderson, and G. J. McGarrity. 1994. Improved methods of retroviral vector transduction and production for gene therapy. Hum. Gene Ther. 5:19-28.
23. Gilboa, E. 1990. Retroviral gene transfer: applications to human therapy. Progress in Clinical and Biological Research 352:301-311.
24. Hawley, R. G., F. H. Lieu, A. Z. C. Fong, and T. S. Hawley. 1994. Versatile retroviral vectors for potential use in gene therapy. Gene Therapy 1:136-138.
25. Varmus, H. 1988. Retroviruses. Science 240:1427-1435.
26. Mann, R., R. C. Mulligan, and D. Baltimore. 1983. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 33:153-159.
27. Landau, N. R., and D. R. Littman. 1992. Packaging system for rapid production of murine leukemia virus vectors with variable tropism. J. Virol. 66:5110-5113.
28. Markowitz, D., S. Goff, and A. Bank. 1988. Construction of a safe and efficient retrovirus packaging cell line. Adv. Exp. Med. Biol. 241:35-40.
29. Markowitz, D., S. Goff, and A. Bank. 1988. A safe packaging line for gene transfer: separating viral genes on two different plasmids. J. Virol. 62:1120-1124.
30. Markowitz, D., S. Goff, and A. Bank. 1988. Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167:400-406.
31. Finer, M. H., T. J. Dull, L. Qin, D. Farson, and M. R. Roberts. 1994. kat: A high-efficiency retroviral transduction system for primary human T lymphocytes. Blood 83:43-50.
32. Morgan, J. R., R. G. Tompkins, and M. L. Yarmush. 1993. Advances in recombinant retroviruses for gene delivery. Advanced Drug Delivery Reviews 12:143-158.
33. Grossman, M., S. E. Raper, K. Kozarsky, E. A. Stein, J. F. Engelhardt, D. Muller, P. J. Lupien, and J. M. Wilson. 1994. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat. Genet. 6:335-341.
34. Weatherall, D. 1994. Heroic gene surgery. Nat. Genet. 6:325-326.
35. Wilson, J. M., N. R. Chowdhury, M. Grossman, R. Wajsman, A. Epstein, R. C. Mulligan, and J. R. Chowdhury. 1990. Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc. Natl. Acad. Sci. USA 87:8437-8441.
36. Miller, D. G., M. A. Adam, and A. D. Miller. 1990. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10:4239-4242.
37. Yee, J.-K., A. Miyanohara, P. LaPorte, K. Bouic, J. C. Burns, and T. Friedmann. 1994. A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc. Natl. Acad. Sci. USA 91:9564-9568.
38. Landau, N. R., K. A. Page, and D. R. Littman. 1991. Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range. J. Virol. 65:162-169.
39. Izquierdo, M., M. Cortes, P. de Felipe, V. Martin, J. Diez-Guerra, A. Talavera, and A. Perez-Higueras. 1995. Long-term rat survival after malignant brain tumor regression by retroviral gene therapy. Gene Therapy 2:66-69.
40. Chen, S.-H., X. H. L. Chen, Y. Wang, K.-I. Kosai, M. J. Finegold, S. S. Rich, and S. L. C. Woo. 1995. Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc. Natl. Acad. Sci. USA 92:2577-2581.
41. Caruso, M., Y. Panis, S. Gagandeep, D. Houssin, J.-L. Salzmann, and D. Klatzmann. 1993. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. USA 90:7024-7028.
42. Neda, H., C. H. Wu, and G. Y. Wu. 1991. Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity. J. Biol. Chem. 266:14143-14146.
43. Russell, S. J., R. E. Hawkins, and G. Winter. 1993. Retroviral vectors displaying functional antibody fragments. Nucleic Acids Res. 21:1081-1085.
44. Miller, N., and R. Vile. 1995. Targeted vectors for gene therapy. FASEB J. 9:190-199.
45. Siegfried, W. 1993. Perspectives in gene therapy with recombinant adenoviruses. Exp. Clin. Endocrinol. 101:7-11.
46. Berkner, K. L. 1988. Development of adenovirus vectors for the expression of heterologous genes. Biotechniques 6:616-629.
47. Trapnell, B. C., and M. Gorziglia. 1994. Gene therapy using adenoviral vectors. Current Opinion in Biotechnology 5:617-625.
48. Forsayeth, J. R., and P. D. Garcia. 1994. Adenovirus-mediated transfection of cultured cells. Biotechniques 17:354-359.
49. Becker, T. C., R. J. Noel, W. S. Coats, A. M. Gomez-Foix, T. Alam, R. D. Gerard, and C. B. Newgard. 1994. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol. 43:161-189.
50. Stratford-Perricaudet, L. D., I. Makeh, M. Perricaudet, and P. Briand. 1992. Widespread long-term gene transfer to mouse skeletal muscles and heart. J. Clin. Invest. 90:626-630.
51. Kay, M. A., C. N. Landen, S. R. Rothenberg, L. A. Taylor, F. Leland, S. Wiehle, B. Fang, D. Bellinger, M. Finegold, A. R. Thompson, M. Read, K. M. Brinkous, and S. L. C. Woo. 1994. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc. Natl. Acad. Sci. USA 91:2353-2357.
52. Rich, D. P., L. A. Couture, L. M. Cardoza, V. M. Giggio, D. Armentano, P. C. Espino, K. Hehir, M. J. Welsh, A. E. Smith, and R. J. Gregory. 1993. Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Hum. Gene Ther. 4:461-476.
53. Kozarsky, K. F., D. R. McKinley, L. L. Austin, S. E. Raper, L. D. Stratford-Perricaudet, and J. M. Wilson. 1994. In vivo correction of low density lipoprotein receptor deficiency in the watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J. Biol. Chem. 269:13695-13702.
54. Herz, J., and R. D. Gerard. 1993. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA 90:2812-2816.
55. Jaffe, H. A., C. Danel, G. Longenecker, M. Metzger, Y. Setoguchi, M. A. Rosenfeld, T. W. Gant, S. S. Thorgeirsson, L. D. Stratford-Perricaudet, M. Perricaudet, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat. Genet. 1:372-378.
56. Fujiwara, T., E. A. Grimm, T. Mukhopadhyay, W.-W. Zhang, L. B. Owen-Schaub, and J. A. Roth. 1994. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res. 54:2287-2291.
57. Setoguchi, Y., H. A. Jaffe, C.-S. Chu, and R. G. Crystal. 1994. Intraperitoneal in vivo gene therapy to deliver α1-antitrypsin to the systemic circulation. Am. J. Respir. Cell Mol. Biol. 10:369-377.
58. Gomez-Foix, A. M., W. S. Coats, S. Baque, T. Alam, R. D. Gerard, and C. B. Newgard. 1992. Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. J. Biol. Chem. 267:25129-25134.
59. Bett, A. J., L. Prevec, and F. L. Graham. 1993. Packaging capacity and stability of human adenovirus type 5 vectors. J. Virol. 67:5911-5921.
60. Yei, S., N. Mittereder, K. Tang, C. O'Sullivan, and B. C. Trapnell. 1994. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Therapy 1:192-200.
61. Crystal, R. G., N. G. McElvaney, M. A. Rosenfeld, C.-S. Chu, A. Mastrangeli, J. G. Hay, S. L. Brody, H. A. Jaffe, N. T. Eissa, and C. Danel. 1994. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42-51.
62. Simon, R. H., J. F. Engelhardt, Y. Yang, M. Zepeda, S., Weber-Pendleton, M. Grossman, and J. M. Wilson. 1993. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Hum. Gene Ther. 4:771-780.
63. Brody, S. L., M. Metzger, C. Danel, M. A. Rosenfeld, and R. G. Crystal. 1994. Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5:821-836.
64. Mittal, S. K., M. R. McDermott, D. C. Johnson, L. Prevec, and F. L. Graham. 1993. Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Res. 28:67-90.
65. Bout, A., M. Perricaudet, G. Baskin, J.-L. Imler, B. J. Scholte, A. Pavirani, and D. Valerio. 1994. Lung gene therapy: in vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium. Hum. Gene Ther. 5:3-10.
66. Ye, S., N. Mittereder, S. Wert, J. A. Whitsett, R. W. Wilmott, and B. C. Trapnell. 1994. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum. Gene Ther. 5:731-744.
67. Muzyczka, N. 1992. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr. Top. Microbiol. Immunol. 158:97-128.
68. Flotte, T. R., X. Barraza-Ortiz, R. Solow, S. A. Afione, B. J. Carter, and W. B. Guggino. 1995. An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction. Gene Therapy 2:29-37.
69. Russell, D. W., A. D. Miller, and I. E. Alexander. 1994. Adeno-associated virus vectors preferentially transduce cells in S phase. Proc. Natl. Acad. Sci. USA 91:8915-8919.
70. Flotte, T. R., S. A. Afione, and P. L. Zeitlin. 1994. Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration. Am. J. Respir. Cell Mol. Biol. 11:517-521.
71. Flotte, T. R., R. Solow, R. A. Owens, S. Afione, P. L. Zeitlin, and B. J. Carter. 1992. Gene expression from adeno-associated virus vectors in airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 7:349-356.
72. Goodman, S., X. Xiao, R. E. Donahue, A. Moulton, J. Miller, C. Walsh, N. S. Young, R. J. Samulski, and A. W. Nienhuis. 1994. Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood 84:1492-1500.
73. Miller, J. L., R. E. Donahue, S. E. Sellers, R. J. Samulsko, N. S. Young, and A. W. Nienhuis. 1994. Recombinant adeno-associated virus (rAAV)-mediated expression of a human γ-globin gene in human progenitor-derived erythroid cells. Proc. Natl. Acad. Sci. USA 91: 10183-10187.
74. Hug, P., and R. G. Sleight. 1991. Liposomes for the transformation of eukaryotic cells. Biochim. Biophys. Acta 1097:1-17.
75. Mihalko, P. J., H. Schreier, and R. M. Abra. 1988. Liposomes: a pulmonary perspective. Liposomes as Drug Carriers 679-694.
76. Behr, J.-P. 1994. Synthetic gene transfer vectors. Pure and Applied Chemistry 66:827-835.
77. Smith, J. G., R. L. Walzem, and J. B. German. 1993. Liposomes as agents of DNA transfer. Biochim. Biophys. Acta 1154:327-340.
78. Mannino, R. J., and S. Gould-Fogerite. 1988. Liposome mediated gene transfer. Biotechniques 6:682-690.
79. Felgner, P. L., T. R. Gadek, M. Holm, R. Roman, H. W. Chan, M. Wenz, J. P. Northrop, G. M. Ringold, and M. Danielsen. 1987. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc. Natl. Acad. Sci. USA 84:7413-7417.
80. Felgner, J. H., R. Kumar, C. N. Sridhar, C. J. Wheeler, Y. J. Tsai, R. Border, P. Ramsey, M. Martin, and P. L. Felgner. 1994. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269:2550-2561.
81. Connor, J., M. B. Yatvin, and L. Huang. 1984. pH-sensitive liposomes: acid-induced liposome fusion. Proc. Natl. Acad. Sci. USA 81:1715-1718.
82. Holmberg, E. G., Q. R. Reuer, E. E. Geisert, and J. L. Owens. 1994. Delivery of plasmid DNA to glial cells using pH-sensitive immunoliposomes. Biochem. Biophys. Res. Commun. 201:888-893.
83. Ghosh, P., P. K. Das, and B. K. Bachhawat. 1982. Targeting of liposomes towards different cell types of rat liver through the involvement of liposomal surface glycosides. Arch. Biochem. Biophys. 213:266-270.
84. Wang, C.-Y., and L. Huang. 1987. pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse. Proc. Natl. Acad. Sci. USA 84:7851-7855.
85. Mizuno, M., J. Yoshida, K. Sugita, I. Inoue, H. Seo, Y. Hayashi, T. Koshizaka, and K. Yagi. 1990. Growth inhibition of glioma cells transfected with the human β-interferon gene by liposomes coupled with a monoclonal antibody. Cancer Res. 50:7826-7829.
86. Egea, M. A., M. L. Garcia, M. A. Alsina, and F. Reig. 1994. Coating of liposomes with transferrin: physicochemical study of the transferrin-lipid system. J. Pharm. Sci. 83:169-173.
87. Curiel, D. T. 1994. High-efficiency gene transfer employing adenovirus-polylysine-DNA complexes. Nat. Immun. 13:141-164.
88. Cotten, M., and E. Wagner. 1993. Non-viral approaches to gene therapy. Current Opinion in Biotechnology 4:705-710.
89. Brigham, K. L., B. Meyrick, B. Christman, M. Magnuson, G. King, and L. C. Berry Jr. 1989. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. Am. J. Med. Sci. 298:278-281.
90. Hazinski, T. A., P. A. Ladd, and C. A. DeMatteo. 1991. Localization and induced expression of fusion genes in the rat lung. Am. J. Respir. Cell Mol. Biol. 4:206-209.
91. Bout, A., D. Valerio, and B. J. Scholte. 1993. In vivo transfer and expression of the lacZ gene in the mouse lung. Exp. Lung Res. 19:193-202.
92. Yoshimura, K., M. A. Rosenfeld, H. Nakamura, E. M. Scherer, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer. Nucleic Acids Res. 20:3233-3240.
93. Alino, S. F., J. Crespo, M. Bobadilla, M. Lejarreta, C. Blaya, and A. Crespo. 1994. Expression of human α1-antitrypsin in mouse after in vivo gene transfer to hepatocytes by small liposomes. Biochem. Biophys. Res. Commun. 204:1023-1030.
94. Logan, J. L., Z. Bebok, L. C. Walker, S. Peng, P. L. Felgner, G. P. Siegal, R. A. Frizzell, J. Dong, M. Howard, S. Matalon, J. R. Lindsey, M. DuVall, and E. J. Sorscher. 1995. Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. Gene Therapy 2:38-49.
95. Canonico, A. E., J. T. Conary, B. O. Meyrick, and K. L. Brigham. 1994. Aerosol and intravenous transfection of human α1-antitrypsin gene to lung of rabbits. Am. J. Respir. Cell Mol. Biol. 10:24-29.
96. Alton, E. W. F. W., P. G. Middleton, N. J. Caplen, S. N. Smith, D. M. Steel, F. M. Munkonge, P. K. Jeffery, D. M. Geddes, S. L. Hart, R. Williamson, K. I. Fasold, A. D. Miller, P. Dickinson, B. J. Stevenson, G. McLachlan, J. R. Dorin, and D. J. Porteous. 1993. Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat. Genet. 5:135-142.
97. Stribling, R., E. Brunette, D. Liggitt, K. Gaensler, and R. Debs. 1992. Aerosol gene delivery in vivo. Proc. Natl. Acad. Sci. USA 89: 11277-11281.
98. Umezawa, F., and Y. Eto. 1988. Liposome targeting to mouse brain: mannose as a recognition marker. Biochem. Biophys. Res. Commun. 153: 1038-1044.
99. Gao, L., E. Wagner, M. Cotten, S. Agarwal, C. Harris, R. Romer, L. Miller, P. C. Hu, and D. Curiel. 1993. Direct in vivo gene transfer to airway epithelium employing adenovirus-polylysine-DNA complexes. Hum. Gene Ther. 4:17-24.
100. Batra, R. K., F. Wang-Johanning, E. Wagner, R. I. Garver Jr., and D. T. Curiel. 1994. Receptor-mediated gene delivery employing lectin-binding specificity. Gene Therapy 1:255-260.
101. Ferkol, T., J. C. Perales, E. Eckman, C. S. Kaetzel, R. W. Hanson, and P. B. Davis. 1995. Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor. J. Clin. Invest. 95:493-502.
102. Perales, J. C., T. Ferkol, M. Molas, and R. W. Hanson. 1994. An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes. Eur. J. Biochem. 226:255-266.
103. Baatz, J. E., M. D. Bruno, P. J. Ciraolo, S. W. Glasser, B. R. Stripp, K. L. Smyth, and T. R. Korfhagen. 1994. Utilization of modified surfactant-associated protein B for delivery of DNA to airway cells in culture. Proc. Natl. Acad. Sci. USA 91:2547-2551.
104. Michael, S. I., and D. T. Curiel. 1994. Strategies to achieve targeted gene delivery via the receptor-mediated endocytosis pathway. Gene Therapy 1:223-232.
105. Rosenfeld, M. A., W. Siegfried, K. Yoshimura, K. Yoneyama, M. Fukayama, L. E. Stier, P. K. Paakko, P. Gilardi, L. Stratford-Perricaudet, M. Perricaudet, S. Jallat, A. Pavirani, L. P. Lecocq, and R. G. Crystal. 1991. Adenovirus-mediated transfer of a recombinant α1-antitrypsin gene to the lung epithelium in vivo. Science 252:431-434.
106. Rosenfeld, M. A., K. Yoshimura, B. C. Trapnell, K. Yoneyama, E. R. Rosenthal, W. Dalemans, M. Fukayama, J. Bargon, L. E. Stier, L. Stratford-Perricaudet, M. Perricaudet, W. B. Guggino, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68:143-155.
107. Zabner, J., L. A. Couture, R. J. Gregory, S. M. Graham, A. E. Smith, and M. J. Welsh. 1993. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75:207-216.
108. Mittereder, N., S. Yei, C. Backhurski, J. Cuppoletti, J. A. Whitsett, P. Tolstoshev, and B. C. Trapnell. 1994. Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5: 717-729.
109. Zhang, W.-W., R. Alemany, J. Wang, P. E. Koch, N. G. Ordonez, and J. A. Roth. 1995. Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Hum. Gene Ther. 6:155-164.
110. Alton, E. W., and D. M. Geddes. 1995. Gene therapy for respiratory diseases: potential applications and difficulties. Thorax 50:484-486.
111. Peault, B., R. Tirouvanziam, M.-N. Sombardier, S. Chen, M. Perricaudet, and D. Gaillard. 1994. Gene transfer to human fetal pulmonary tissue developed in immunodeficient SCID mice. Hum. Gene Ther. 5:1131-1137.
112. Engelhardt, J. F., L. Litzky, and J. M. Wilson. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5:1217-1229
113. Korst, R. J., B. Bewig, and R. G. Crystal. 1995. In vitro and in vivo transfer and expression of human surfactant SP-A- and SP-B-associated protein cDNAs mediated by replication-deficient, recombinant adenoviral vectors. Hum. Gene Ther. 6:277-287.
114. Drazen, K. E., L. Wu, X.-D. Shen, D. Bullington, O. Jurim, R. W. Busuttil, and A. Shaked. 1995. Adenovirus mediated gene transfer in the transplant setting. Transplantation 59:670-673.
115. Amin, R., R. Wilmott, Y. Schwarz, B. Trapnell, and J. Stark. 1995. Replication-deficient adenovirus induces expression of interleukin-8 by airway epithelial cells in vitro. Hum Gene Ther. 6:145-153.
116. Morse, J. O. 1978. Alphal-antitrypsin deficiency. N. Engl. J. Med. 299:1099-2005.
117. Crystal, R. G., M. L. Brantly, R. C. Hubbard, D. T. Curiel, M. D. States, and M. D. Holmes 1989. The alphal-antitrypsin gene and its mutations. Chest 95:196-208.
118. mineral springs allele. Mol. Cell. Biol. 10:47-56.
119. mattawa gene. J. Clin. Invest. 83:1144-1152.
120. malton. J. Biol. Chem. 264:13938-13945.
121. Wewers, M. D., M. A. Casolaro, S. E. Sellers, S. C. Swayze, K. M. McPhaul, and J. T. Wittes. 1987. Replacement therapy for alpha1-antitrypsin deficiency associated with emphysema. N. Engl. J. Med. 316:1055-1062.
122. Hubbard, R., S. Sellers, D. Czerski, L. Stephens, and R. G. Crystal. 1988. Efficacy and safety of augmentation therapy of α1-antitrypsin deficiency with monthly infusions of α1-antitrypsin. JAMA 260: 1259-1264.
123. Garver, R. I. Jr., A. Chytil, M. Courtney, and R. G. Crystal. 1987. Clonal gene therapy: transplanted mouse fibroblast clones express the human α1-antitrypsin gene in vivo. Science 237:762-764.
124. Kozarsky, K., N. Grossman, and J. M. Wilson. 1993. Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia. Somat. Cell Mol. Genet. 19: 449-458.
125. Kay, M. A., Q. Li, T.-J. Liu, F. Leland, C. Toman, M. Finegold, and S. L. C. Woo. 1992. Hepatic gene therapy: persistent expression of human α1-antitrypsin in mice after direct gene delivery in vivo. Hum. Gene Ther. 3:641-647.
126. Cardoso, J. E., S. Branchereau, P. R. Jeyaraj, D. Houssin, O. Danos, and J. M. Heard. 1993. In situ retrovirus-mediated gene transfer into dog liver. Hum. Gene Ther. 4:411-418.
127. Riordan, J. R., J. M. Rommens, B.-S. Kerem, N. Alon, R. Rozmahel, Z. Grzelczak, J. Zielenski, S. Lok, N. Plavsic, J.-L. Chou, M. L. Drumm, M. C. Iannuzzi, F. S. Collins, and L.-C. Tsui. 1989. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245:1066-1073.
128. Rommens, J. M., M. C. Iannuzzi, B.S. Kerem, M. L. Drumm, G. Melmer, M. Dean, R. Rozmahel, J. L. Cole, D. Kennedy, N. Hidaka, M. Zsiga, M. J. Buchwald, R. Riordan, L.-C. Tsui, and F. S. Collins. 1989. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245:1059-1065.
129. Collins, F. S. 1992. Cystic fibrosis: molecular biology and therapeutic implications. Science 256:774-779.
130. Welsh, M. J., and A. E. Smith. 1993. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 73:1251-1254.
131. Mulligan, R. C. 1993. The basic science of gene therapy. Science 260: 926-932.
132. Pilewski, J. M., and R. A. Frizzell. 1995. How do CFTR mutations cause lung disease? Curr. Opin. Pulm. Med. 1:435-443.
133. Rich, D. P., M. P. Anderson, R. J. Gregory, S. H. Cheng, S. Paul, D. M. Jefferson, J. D. McCann, K. W. Klinger, A. E. Smith, and M. J. Welsh. 1990. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature 347:358-363.
134. Boucher, R. C. 1994. Airway epithelial fluid transport. Am. Rev. Respir. Dis. 150:271-281, 581-593.
135. Cheng, P. W., T. F. Boat, K. Cranfill, J. R. Yankaskas, and R. C. Boucher. 1989. Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis. J. Clin. Invest. 84:68-72.
136. Barasch, J., B. Kiss, A. Prince, L. Saiman, D. Gruenert, and Q. Al-Awqati. 1992. Acidification of intracellular organelles is defective in cystic fibrosis. Nature 352:70-73.
137. Imundo, L., J. Barasch, A. Prince, and Q. Al-Awqati. 1995. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc. Natl. Acad. Sci. USA 92:3019-3023.
138. Bradbury, N. A., T. Jilling, G. Berta, E. J. Sorscher, R. J. Bridges, and K. L. Kirk. 1992. Regulation of plasma membrane recycling by CFTR. Science 256:530-532.
139. Lloyd Mills, C., M. M. C. Pereira, R. L. Dormer, and M. A. McPherson. 1992. An antibody against a CFTR derived synthetic peptide inhibits beta-adrenergic stimulation of mutin secretion. Biochem. Biophys. Res. Commun. 188:1146-1152.
140. Trapnell, B. C., C.-S. Chu, P. K. Paako, T. C. Banks, K. Yoshimura, V. J. Ferrans, M. S. Chernick, and R. G. Crystal. 1991. Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. USA 88:6565-6569.
141. Engelhardt, J. F., M. Zepeda, J. A. Cohn, J. R. Yankaskas, and J. M. Wilson. 1994. Expression of the cystic fibrosis gene in adult human lung. J. Clin. Invest. 93:737-749.
142. Engelhardt, J. F., J. R. Yankaskas, S. A. Ernst, Y. Yang, C. R. Marino, R. C. Boucher, J. A. Cohn, and J. M. Wilson. 1992. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2:240-248.
143. Jacquot, J., E. Puchelle, J. Hinnrasky, C. Fuchey, C. Bettinger, C. Spilmont, N. Bonnet, A. Dieterle, D. Dreyer, A. Pavirani, and W. Dalemans. 1993. Localization of the cystic fibrosis transmembrane conductance regulator in airway secretory glands. Eur. Respir. J. 6:169-176.
144. Richardson, P. S., and E. W. F. W. Alton. 1993. Cystic fibrosis transmembrane conductance regulator protein: what is its role in cystic fibrosis? Eur. Respir. J. 6:160-162.
145. Drumm, M. L., H. A. Pope, W. H. Cliff, J. M. Rommens, S. A. Marvin, L.-C. Tsui, F. S. Collins, R. A. Frizzell, and J. M. Wilson. 1990. Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell 62:1227-1233.
146. Rich, D. P., M.P. Anderson, R. J. Gregory, S. H. Cheng, S. Paul, D. M. Jefferson, J. D. McCann, K. W. Klinger, A. E. Smith, and M. J. Welsh. 1990. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature 347:358-363.
147. Johnson, L. G., J. C. Olsen, B. Sarkadi, K. L. Moore, R. Swanstrom, and R. C. Boucher. 1992. Effciency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat. Genet. 2:21-25.
148. Johnson, L. G., S. E. Boyles, J. Wilson, and R. C. Boucher. 1995. Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells. J. Clin. Invest. 95:1377-1382.
149. Engelhardt, J. F., Y. Yang, L. D. Stratford-Perricaudet, E. D. Allen, K. Kozarsky, M. Perricaudet, J. R. Yankaskas, and J. M. Wilson. 1993. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat. Genet. 4:27-34.
150. Mastrangeli, A., C. Danel, M. A. Rosenfeld, L. Stratford-Perricaudet, M. Perricaudet, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1993. Diversity of airway epithelial cell targets for in vivo recombinant adenvirus-mediated gene transfer. J. Clin. Invest. 91:225-234.
151. Engelhardt, J. F., R. H. Simon, Y. Yang, M. Zepeda, S. Weber-Pendleton, B. Doranz, M. Grossman, and J. M. Wilson. 1993. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum. Gene Ther. 4:759-769.
152. Pilewski, J. M., J. F. Engelhardt, L. R. Kaiser, J. E. Bavaria, J. M. Wilson, and S. M. Albelda. 1995. Adenovirus-mediated gene transfer to submucosal glands in vivo using xenografts. Am. J. Physiol. 268(Lung Cell. Mol. Physiol. 12):L657-L665.
153. Grubb, B. R., R. J. Pickles, H. Ye, J. R. Yankaskas, R. N. Vick, J. F. Engelhardt, J. M. Wilson, L. G. Johnson, and R. C. Boucher. 1994. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 371:802-806.
154. Wickham, T. J., P. Mathias, D. A. Cheresh, and G. R. Nemerow. 1993. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 73:309-319.
155. Goldman, M. J., and J. M. Wilson. 1995. Expression of αvβ5 integrin is necessary for efficient adenovirus-mediated gene transfer in human airway. J. Virol. 69:5951-5958.
156. Bout, A., J.-L. Imler, H. Schultz, M. Perricaudet, C. Zurcher, P. Herbrink, D. Valerio, and A. Pavirani. 1994. In vivo adenovirus-mediated transfer of human CFTR cDNA to rhesus monkey airway epithelium: efficacy, toxicity, and safety. Gene Therapy 1:385-394.
157. Yang, Y., Q. Li, H.C.J. Ertle, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenovirus. J. Virol. 69:2004-2015.
158. Goldman, M., Y. Yang, and J. M. Wilson. 1995. Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect. Nat. Genet. 9:126-131.
159. Zabner, J., D. M. Peterson, A. P. Puga, S. M. Graham, L. A. Couture, L. D. Keyes, M. J. Lukason, J. A. St. George, R. J. Gregory, A. E. Smith, and M. J. Welsh. 1994. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nat. Genet. 6:75-83.
160. Flotte, T. R., S. A. Afione, C. Conrad, S. A. McGrath, R. Solow, H. Oska, P. L. Zeitlin, W. B. Guggino, and B. J. Carter. 1993. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc. Natl. Acad. Sci. USA 90:10613-10617.
161. Halbert, C. L., I. E. Alexander, G. M. Wolgamot, and A. D. Miller. 1995. Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells. J. Virol. 69:1473-1479.
162. Teramoto, S., D. McCarty, X. Xiao, R. J. Samulski, and R. C. Boucher. 1995. Efficiency of gene transfer by adeno-associated virus to human airway epithelial cells. Am. J. Respir. Crit. Care Med. 151:A670. (Abstr.)
163. Hyde, S. C., D. R. Gill, C. F. Higgins, A. E. O. Trezise, L. J. MacVinish, A. W. Cuthbert, R. Ratcliff, M. J. Evans, and W. H. Colledge. 1993. Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy. Nature 362:250-255.
164. Leigh, M. W., J. E. Kylander, J. R. Yankaskas, and R. C. Boucher. 1995. Cell proliferation in bronchial epithelium and submucosal glands of cystic fibrosis patients. Am. J. Respir. Cell Mol. Biol. 12:605-612.
165. Ballard, P. L., M. L. Zepeda, M. Schwartz, N. Lopez, and J. M. Wilson. 1995. Adenovirus-mediated gene transfer to human fetal lung ex vivo. Am. J. Physiol. 268(Lung Cell. Mol. Physiol. 12):L839-L845.
166. McCray, P. B., K. Armstron, J. Zabner, D. W. Miller, G. A. Koretzky, L. Couture, J. E. Robillard, A. E. Smith, and M. J. Welsh. 1995. Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo. J. Clin. Invest. 95:2620-2632.
167. Pitt, B. R., M. A. Schwarz, J. M Pilewski, D. Nakayama, G. M. Mueller, P. D. Robbins, S. A. Watkins, K. H. Albertine, and R. D. Bland. 1995. Retrovirus-mediated gene transfer in lungs of living fetal sheep. Gene Therapy 2:344-350.
168. Miyanohara, A., J.-K. Yee, K. Bouic, P. LaPorte, and T. Friedman. 1995. Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors. Gene Therapy 2:138-142.
169. Friedman, T., and J.-K. Yee. 1995. Pseudotype retroviral vectors for studies of human gene therapy. Nature Medicine 1:275-277.
170. Knowles, M. R., K. W. Hohneker, Z. Zhou, J. C. Olsen, T. L. Noah, P. C. Hu, M. W. Leigh, J. F. Engelhardt, L. J. Edwards, K. R. Jones, M. Grossman, J. M. Wilson, L. G. Johnson, and R. C. Boucher. 1995. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N. Engl. J. Med. 333: 823-831.
171. Caplen, N. J., E. W. F. W. Alton, P. G. Middleton, J. R. Dorin, B. J. Stevenson, X. Gao, S. R. Durham, P. K. Jeffery, M. E. Hodson, C. Coutelle, L. Huang, D. J. Porteous, R. Williamson, and D. M. Geddes. 1995. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nature Medicine 1:39-46.
172. Sorscher, E. J., J. J. Logan, R. A. Frizzell, R. K. Lyrene, Z. Bebok, J. Y. Dong, M. D. Duvall, P. L. Felgner, S. Matalon, L. Walker, and B. J. Wiatrak. 1994. Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway. Hum. Gene Ther. 5:1259-1277.
173. Ezurum, S. C., P. Lemarchand, M. A. Rosenfeld, J.-H. Yoo, and R. G. Crystal. 1993. Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA. Nucleic Acids Res. 21:1607-1612.
174. Conary, J. T., R. E. Parker, B. W. Christman, R. D. Faulks, G. A. King, B. O. Meyrick, and K. L. Brigham. 1994. Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. J. Clin. Invest. 93:1834-1840.
175. Kolls, J., K. Peppel, M. Silva, and B. Beutler. 1994. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA 91:215-219.
176. Adams, L. B., C. M., Mason, J. K. Kolls, D. Scollard, J. L. Krahenbuhl, and S. Nelson. 1995. Exacerbation of acute and chronic murine tuberculosis by administration of tumor necrosis factor receptor-expressing adenovirus. J. Infect. Dis. 171:400-405.
177. Xing, Z., T. Braciak, M. Jordana, K. Croitoru, F. L. Graham, and J. Gauldie. 1994. Adenovirus-mediated cytokine gene transfer at tissue sites. J. Immunol. 153:4059-4069.
178. Yei, S., C. J. Bachurski, T. E. Weaver, S. E. Wert, B. C. Trapnell, and J. A. Whitsett. 1994. Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells. Am. J. Respir. Cell Mol. Biol. 11:329-336.
179. Lemarchand, P., M. Jones, C. Danel, I. Yamada, A. Mastrangeli, and R. G. Crystal. 1994. In vivo adenovirus-mediated gene transfer to lungs via pulmonary artery. J. Appl. Physiol. 76:2840-2845.
180. Muller, D. W. M., D. Gordon, H. San, Z. Yang, V. J. Pompili, G. J. Nabel, and E. G. Nabel. 1994. Catheter-mediated pulmonary vascular gene transfer and expression. Circ. Res. 75:1039-1049.
181. Chang, M. W., E. Barr, J. Seltzer, Y. Q. Jiang, G. J. Nabel, E. G. Nabel, M. S. Parmacek, and J. M. Leiden. 1995. Cytostic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product. Science 267:518-522.
182. von der Leyen, H. E., G. H. Gibbons, R. Morishita, N. P. Lewis, L. Zhang, M. Nakajima, Y. Kaneda, J. P. Cooke, and V. J. Dzau. 1995. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc. Natl. Acad. Sci. USA 92:1137-1141.
183. Bruyns, C., C. Gérard, and T. Velu. 1994. Cancer escape from immune surveillance: how can it be overcome by gene transfer? Eur. J. Cancer 30A:1176-1181.
184. Culver, K. W., and R. M. Blaese. 1994. Gene therapy for cancer. Trends Genet. 10:5:174-178.
185. Dubinett, S. M., L. Patrone, J. Tobias, A. J. Cochran, D.-R. Wen, and W. H. McBride. 1993. Intratumoral interleukin-2 immunotherapy: activation of tumor-infiltrating and splenic lymphocytes in vivo. Cancer Immunol. Immunother. 36:156-162.
186. Ohira, T., Y. Ohe, Y. Heike, E. R. Oidack, K. J. Olsen, K. Nishio, M. Nishio, Y. Miyahara, Y. Funayama, H. Ogasawara, H. Arioka, H. Kato, and N. Saijo. 1994. Gene therapy for Lewis lung carcinoma with tumor necrosis factor and interleukin 2 cDNAs co-transfected subline. Gene Therapy 1:269-275.
187. Carbone, D. P., and J. D. Minna. 1992. The molecular genetics of lung cancer. Adv. Intern. Med. 37:153-171.
188. Mukhopadhyay, T., M. Tainsky, A. C. Cavender, and J. A. Roth. 1991. Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res. 51:1744-1748.
189. Georges, R. N., T. Mukhopadhyay, Y. Zhang, N. Yen, and J. A. Roth. 1993. Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct. Cancer Res. 53:1743-1746.
190. Kern, J. A., D. A. Schwartz, J. E. Nordberg, D. B. Weiner, M. I. Green, L. Torney, and R. A. Robinson. 1990. p185 neu expression in human lung adenocarcinomas predict shortened survival. Cancer Res. 50:5184-5191.
191. Deshane, J., F. Loechel, R. M. Conry, G. P. Siegal, C. R. King, and D. T. Curiel. 1994. Intracellular single-chain antibody directed against erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. Gene Therapy 1:332-337.
192. Carbone, D. P., and J. D. Minna. 1994. In vivo gene therapy of human lung cancer using wild-type p53 delivered by retrovirus. J. Natl. Cancer Inst. 86:1437-1438.
193. Cai, D. W., T. Mukhopadhyay, Y. Liu, T. Fujiwara, and J. A. Roth. 1993. Stable expression of the wide-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum. Gene Ther. 4:617-624.
194. Zhang, W.-W., X. Fang, W. Mazur, B. A. French, R. N. Georges, and J. A. Roth. 1994. High-efficiency gene transfer and high-level expression of wild type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther. 1:5-13.
195. Fujiwara, T., E. A. Grimm, T. Mukhopadhyay, D. W. Cai, L. B. Owen-Schaub, and J. A. Roth. 1993. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res. 53:4129-4133.
196. Fujiwara, T., E. A. Grimm, T. Mukhopadhyay, D. W. Cai, L. B. Owen-Schaub, and J. A. Roth. 1994. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res. 54:2287-2291.
197. Liu, T.-J., W.-W. Zhang, D. L. Taypor, J. A. Roth, H. Goepfert, and G. L. Clayman. 1994. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 54:3662-3667.
198. Van Meir, E. G., P. J. Polverini, V. R. Chazin, H. J. Su Huang, N. de Tribolet, and W. K. Cavenee. 1994 Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat. Genet. 8:171-176.
199. Sorrentino, B. P., S. J. H. Brandt, D. Bodine, M. Gottesman, I. Pastan, A. Cline, and A. W. Nienhuis. 1992. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science 257:99-102.
200. Moolten, F. L. 1994. Drug sensitivity ("suicide") genes for selective cancer therapy. Cancer Gene Therapy 1:279-287.
201. Smythe, W. R., H. C. Hwang, K. M. Amin, S. L. Eck, B. L. Davidson, J. M. Wilson, L. R. Kaiser, and S. M. Albelda. 1994. Use of recombinant adenovirus to transfer the herpes symplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system. Cancer Res. 54:2055-2059.
202. Smythe, W. R., L. R. Kaiser, H. C. Hwang, K. M. Amin, J. M. Pilewski, S. J. Eck, J. M. Wilson, and S. M. Albelda. 1994. Successful adenovirus-mediated gene therapy in an in vivo model of human malignant mesothelioma. Ann. Thorac. Surg. 57:1395-1401.
203. Brody, S. L., H. A. Jaffe, S. K. Han, R. P. Wersto, and R. G. Crystal. 1994. Direct in vivo gene transfer and expression malignant cells using adenovirus vectors. Hum. Gene Ther. 5:437-447.
204. Hasegawa, Y., N. Emi, K. Shirnokata, A. Abe, T. Kawabe, T. Hasegawa, T. Kirioka, and H. Saito. 1993. Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors. Am. J. Respir. Cell Mol. Biol. 8:655-661.
205. Smythe, W. R., H. C. Hwang, A. A. Elshami, K. M. Amin, S. L. Eck, B. L. Davidson, J. M. Wilson, L. R. Kaiser, and S. M. Albelda. 1995. Successful treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex-thymidine kinase gene. Ann. Surg. 222:78-86.
206. Hwang, H. C., W. R. Smythe, A. A. Elshami, J. C. Kucharczuk, K. M. Amin, J. P. Williams, L. A. Litzky, L. R. Kaiser, and S. M. Albelda. 1995. Gene therapy using adenovirus carrying the herpes simplex thymidine kinase gene to treat in vitro models of human malignant mesothelioma and lung cancer. Am. J. Respir. Cell Mol. Biol., 13:7-16.
207. Elshami, A., J. Kucharczuk, H. Zhang, W. R., Smythe, H. C. Huang, K. Amin, L. A. Litzky, L. R. Kaiser, and S. M. Albelda. 1995. Treatment of malignant pleural mesothelioma in an immunocompetent rat model utilizing adenovirus-mediated gene therapy-efficacy and toxicity studies. Human Gene Therapy (In press)
208. Garver, R. I., Jr., K. T. Goldsmith, B. Rodu, P.-C. Hu, E. J. Surscher, and D. T. Curiel. 1994. Strategy for achieving selective killing of carcinomas. Gene Therapy 1:46-50.
209. Harris, J. D., A. A. Gutierrez, H. C. Hurst, K. Sikora, and N. R. Lemoine. 1994. Gene therapy for cancer using tumor-specific prodrug activation. Gene Therapy 1:170-175.
210. Osaka, T., Y. Tanio, I. Tachibana, S. Hosoe, T. Kumagai, I. Kawase, S. Oikawa, and T. Kishimoto. 1994 Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene. Cancer Res. 54:5258-5261.
211. Weichselbaum, R. R., D. E. Hallahan, M. A. Beckett, H. J. Mauceri, H. Lee, V. P. Sukhatme, and D. W. Kufe. 1994. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res. 54:4266-4269.