Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases

Brain Research

Volumn 885, Issue 1, 2000, Pages 117-121

  Togo, Takashi ^a,b   Akiyama, Haruhiko ^a   Kondo, Hiromi ^a   Ikeda, Kenji ^a   Kato, Masanori ^c   Iseki, Eizo ^b   Kosaka, Kenji ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c Soga Hospital   (Japan)

Author keywords

Amyloid protein; Blood vessel; Inflammation; Microglia

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; CD 40 ANTIGEN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; MICROGLIA; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANTIBODY SPECIFICITY; ANTIGENS, CD40; BRAIN CHEMISTRY; DOWN SYNDROME; HUMANS; MICROGLIA; SCHIZOPHRENIA;

EID: 0034571241     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02984-X     Document Type: Article

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2. 2 secretion by microglia during antigen presentation to Th1 cells
3. Antibodies to distinct epitopes on the CD40 molecule co-operate in stimulation and can be used for the detection of soluble CD40
4. Mature microglia resemble immature antigen-presenting cells
5. Activation of human dendritic cells through CD40 cross-linking
6. CD40 is functionally expressed on human thymic epithelial cells
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9. + T-cells
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13. Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β
14. A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes
15. Alzheimer's β-amyloid peptides induce inflammatory cascade in human vascular cells: the role of cytokines and CD40
16. Microglial activation resulting from CD40-CD40L interaction after β-amyloid stimulation
17. Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis
18. Induction of CD40 on human endothelial cells by Alzheimer's β-amyloid peptides