Allosteric inhibition of glycogen phosphorylase α by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2- methyl-pyridine-3,5,6-tricarboxylate

Protein Science

Volumn 8, Issue 10, 1999, Pages 1930-1945

  Oikonomakos, Nikos G ^a   Tsitsanou, Katerina E ^a   Zographos, Spyros E ^a   Skamnaki, Vicky T ^a   Goldmann, Siegfried ^b   Bischoff, Hilmar ^b  

^a Industrial Enzymology Unit   (Greece)

^b BAYER AG   (Germany)

Author keywords

Allosteric site; Crystal structure; Diabetes; Glycogen metabolism; Inhibition; Phosphorylase

Indexed keywords

3 ISOPROPYL 4 (2 CHLOROPHENYL) 1,4 DIHYDRO 1 ETHYL 2 METHYLPYRIDINE 3,5,6 TRICARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; GLUCOSE; GLUCOSE 1 PHOSPHATE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; GLYCOGEN METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0032882213     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.10.1930     Document Type: Article

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