Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of D-gluco- and D-xylopyranosylidene-spiro-(thio)hydantoins and N-(D-glucopyranosyl) amides

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2843-2848

  Somsak L ^a   Kovacs L ^a   Toth M ^a   Osz E ^a   Szilagyi L ^a   Gyorgydeak Z ^a   Dinya, Z ^a   Docsa, T ^a   Toth B ^a   Gergely, P ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; C (1 BROMO 1 DEOXY BETA DEXTRO GLYCOPYRANOSYL)FORMAMIDE; CYANIC ACID; DEXTRO GLUCOPYRANOSYLIDENESPIRO(THIO)HYDANTOIN; DEXTRO XYLOPYRANOSYLIDENESPIRO(THIO)HYDANTOIN; GLYCOGEN PHOSPHORYLASE; LIVER ENZYME; MUSCLE ENZYME; N (DEXTRO GLUCOPYRANOSYL)AMIDE; THIOCYANATE; THIOHYDANTOIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DIABETES MELLITUS; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HYDROGEN BOND; HYPERGLYCEMIA; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

AMIDES; ENZYME INHIBITORS; HYDANTOINS; HYDROGEN BONDING; HYPOGLYCEMIC AGENTS; LIVER; MOLECULAR CONFORMATION; MONOSACCHARIDES; MUSCLES; PHOSPHORYLASE A; PHOSPHORYLASE B; PHOSPHORYLASES; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035899177     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010892t     Document Type: Article

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