Intramolecular interactions mediate pH regulation of connexin43 channels

Biophysical Journal

Volumn 70, Issue 3, 1996, Pages 1294-1302

  Morley, Gregory E ^a   Taffet, Steven M ^a   Delmar, Mario ^a,b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CONNEXIN 43; FLUORESCENT DYE; MESSENGER RNA;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL JUNCTION; CELL PH; CHANNEL GATING; CONTROLLED STUDY; CROSS REACTION; MEMBRANE CONDUCTANCE; MOLECULAR INTERACTION; NONHUMAN; OOCYTE; RAT; RECEPTOR BINDING; VOLTAGE CLAMP; XENOPUS;

ANIMALIA;

EID: 0030050142     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79686-8     Document Type: Article

References (55)

1. Arellano, R. O., F. Ramon, A. Rivera, and G. Zampighi. 1988. Calmodulin acts as an intermediary for the effects of calcium on gap junctions from crayfish lateral axons. J. Membr. Biol. 101:119-131.
2. Armstrong, C. M., and F. Bezanilla. 1977. Inactivation of the sodium channel. II. Gating current experiments. J. Gen. Physiol. 70:567-590.
3. Barrio, L. C., T. Suchyna, T. Bargiello, L. X. Xu, R. S. Roginski, M. V. L. Bennett, and B. J. Nicholson. 1991. Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage. Proc. Natl. Acad. Sci. USA. 88:8410-8414.
4. Bennett, M. V. L., L. C. Barrio, T. A. Bargiello, D. C. Spray, E. Hertzberg, and J. C. Saez. 1991. Gap Junctions: new tools, new answers, new questions. Neuron. 6:305-320.
5. Bennett, M. V. L., and V. K. Verselis. 1992. Biophysics of gap junctions. Semin. Cell Biol. 3:29-47.
6. Bennett, M. V. L., R. L. Verselis, R. L. White, and D. C. Spray. 1988. Gap junctional conductance: gating. In Gap Junctions. E. L. Herzberg and R. G. Johnson, editors. Alan R. Liss. New York. 287-304
7. Bennett, M. V. L., X. Zheng, and M. L. Sogin. 1995. The connexin family tree. In Intercellular Communication Through Gap Junctions. Y. Kanno, editor. Elsevier, Amsterdam. 3-8.
8. Beyer, E. C., D. L. Paul, and D. A. Goodenough. 1987. Connexin43: a protein from rat heart homologus to a gap junction protein from liver. J. Cell Biol. 105:2621-2629.
9. Blank, P. S., H S. Silverman, O. Y. Chung, B. Hogue, M. D. Stern, R. G. Hansford, E. G. Lakatta, and M. C. Capogrossi. 1992. Cytosolic pH measurements in single cardiac myocytes using carboxy-seminaphtorhodafluor-1. Am. J. Physiol. 263:H276-H284.
10. Britz-Cunningham, S. H., M. M. Shah, C. W. Zuppan, and W. H. Fletcher. 1995. Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality. N. Engl. J. Med. 332: 1323-1329.
11. Bruzzone, R., T. W. White, and D. L. Paul 1994. Expression of chimeric connexins reveals new properties of the formation and gating behavior of gap junction channels. J. Cell Sci. 107:955-967.
12. Creighton, T. E. 1993. Proteins: Structures and Molecular Properties. W. H. Freeman, New York.
13. Delmar, M., J. Jalife, and D C. Michaels. 1986 Effects of changes in excitability and intercellular coupling on synchronization in the rabbit sino-atrial node. J. Physiol. (Lond.). 370:127-150
14. Delmar, M., S. Liu, G. E. Morley, J. F. Ek, J. M. B. Anumonwo, and S. M. Taffet. 1994. Toward a molecular model for the pH regulation of intercellular communication in the heart. In Cardiac Electrophysiology. From Cell to Bedside. D. P. Zipes and J. Jalife, editors. W. B. Saunders, Philadelphia. 135-143.
15. Delmar, M., D. C. Michaels, T. Johnson, and J. Jalife. 1987. Effects of increasing intercellular resistance on transverse and longitudinal propagation in sheep epicardial muscle. Circ. Res. 60:780-785.
16. Dumont, J. N. 1972. Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J. Morphol. 136: 153-180.
17. Dunham, B., S. Liu, S. Taffet, E. Trabka-Janik, M. Delmar, R. Petryshyn, S. Zheng, R. Perzova, and M. L. Vallano. 1992. Immunolocalization and expression of functional and non-functional wild-tpe and mutant rat heart connexin43 cDNA. Circ Res. 70:1233-1243.
18. Ek, J. F., M. Delmar, R. Perzova, and S. M. Taffet. 1994. Role of histidine 95 on the pH gating of the cardiac gap junction protein connexin43. Circ. Res. 74:1058-1064
19. Esinduy, C. B., C. Cheng Chang, J. E. Trosko, and R. J. Ruch. 1995. In vitro growth inhibition of neoplastically transformed cells by nontransformed cells: requirement for gap junctional intercellular communication. Carcinogenesis. 16:915-921.
20. Fishman, G. I., A. P. Moreno, D. C. Spray, and L. A. Leinwald. 1991. Functional analysis of human cardiac gap junction channel mutants. Proc. Natl. Acad. Sci. USA. 88:3525-3529.
21. Gettes, L. S., J. W. Buchanan, T. Saito, Y. Kagiyama, S. Oshita, and T. Fujino. 1985. Studies concerned with slow conduction. In Cardiac Electrophysiology and Arrhythmias. D. P. Zipes and J. Jalife, editors. Grune and Stratton, Orlando. 81-87
22. Granot, I , and N. Dekel. 1994. Phosphorylation and expression of Connexin-43 ovarian gap junction protein are regulated by luteinizing hormone. J. Biol. Chem. 269:30502-30509.
23. Hoshi, T., W. N. Zagotta, and R. W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
24. Koval, M , S. T. Geist, E. M. Westphale, A. E. Kemendy, R. Civitelli, E. C. Beyer, and T. H. Stemberg. 1995. Transfected Connexin45 alters gap junction permeability in cells expressing endogenous Connexin43. J. Cell Biol. 130:987-995.
25. Kramer, R. H , E. Goulding, and S. A. Siegelbaum. 1994. Potassium channel inactivation peptide blocks cyclic nucleotide-gated channels by binding to the conserved pore domain. Neuron. 12:655-662.
26. Kyte, J. 1995. Structure in Protein Chemistry. Garland Publishing, New York.
27. Lang, L. M., E. C. Beyer, A. L. Schwartz, and J. D. Gitlin. 1991. Molecular cloning of rat uterine gap junction protein and analysis of gene expression during gestation. Am. J. Physiol. 260:E787-E793.
28. Lazrak, A., and C. Peracchia 1993. Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells. Biophys. J. 65:2002-2012.
29. Liu, S , S. Taffet, L. Stoner, M Delmar, M. L. Vallano, and J. Jalife. 1993. A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxyl tail length. Biophys. J 64:1422-1433.
30. Loo, L. W. M., J. M. Berestecky, M. Y Kanemitsu, and A. F Lau. 1995. pp60src-mediated phosphorylation of Connexin 43, a gap junction protein J Biol Chem. 270:12751-12761.
31. Meda, P , C. Vozzi, S. Ullrich, E. Dupont. A Charollais, E. Sutler, and D. Bosco. 1995. Gland cell connexins. In Intercellular Communication Through Gap Junctions. Y Kanno, K. Kataoka, Y. Shiba, Y. Shibata, and T. Shimazu, editors. Elsevier, Amsterdam. 281-287.
32. Moreno, A. P , J. C. Saez, G. I. Fishman, and D. C. Spray. 1994. Human Connexin43 gap junction channels: regulation of unitary conductances by phosphorylation. Circ. Res. 74:1050-1057.
33. Noma, A., and N. Tsuboi. 1987. Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guineapig. J. Physiol. (Lond.). 382:193-211.
34. Reaume, A. G., P. A de Sousa, S. Kulkarni, B. Lowell Langille, D. Zhu, T. C. Davies, S. C. Juneja, G. M. Kidder, and J. Rossant. 1995. Cardiac malformation in neonatal mice lacking Connexin43. Science. 267: 1831-1834.
35. Risek, B., S. Guthrie, N. Kumar, and N B. Gilula. 1990. Modulation of gap junction transcript and protein expression during pregnancy in the rat. J. Cell Biol. 110:269-282.
36. Saffitz, J. E., L. M. Davis, B. J. Darrow, H. L. Kanter, J. G. Laing, and E. C. Beyer. 1995. The molecular basis of anisotropy: role of gap junctions. J. Cardiovasc. Electrophysiol. 6:498-510.
37. Spray, D. C., and M. V. L. Bennett. 1985. Physiology and pharmacology of gap junctions. Annu. Rev. Physiol. 47:281-303.
38. Spray, D. C., and J. M. Burt. 1990. Structure-activity relations of the cardiac gap junction channel. Am J. Physiol. 258:C195-C205.
39. Spray, D C., R. D. Ginzberg, E. A. Morales, Z. Gatmaitan, and I. M. Arias. 1986. Electrophysiological properties of gap junctions between dissociated pairs of rat hepatocytes. J. Cell Biol. 103:135-144.
40. Spray, D. C., A. L. Harris, and M. V. L. Bennett. 1981. Equilibrium properties of a voltage-dependent junctional conductance. J. Gen. Physiol. 77:77-93.
41. 2-connexin (connexin-26) can form heteromeric hemichannels. J. Biol. Chem. 270:6768-6772.
42. Stauffer, K. A , and N. Unwin. 1992. Structure of gap junction channels. Semin. Cell Biol. 3:17-20.
43. Suchyna, T. M., L. Xian-Xu, F. Gao, C. R. Fourtner, and B. J. Nicholson. 1993. Identification of a proline residue as a transduction element involved in voltage gating of gap junctions. Nature. 365:847-849.
44. Tabb, T., G. Thilander, A. Grover, E Hertzberg, and R. E. Garfield. 1992. An immunochemical and immunocytologic study of the increase in myometrial gap junctions (and connexin 43) in rats and humans during pregnancy. Am. J. Obstet. Gynecol. 167:559-567.
45. Takahashi, T., E. Neher, and B. Sakmann. 1987. Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels. Proc. Natl Acad. Sci. USA. 84:5063-5067.
46. + channel. Biochemistry. 33:7220-7228.
47. Unwin, N. 1995. Acetylcholine receptor channel imaged in the open state. Nature. 373:37-43.
48. Unwin, P. N. T., and P. D. Ennis. 1984. Two configurations of a channel-forming membrane protein. Nature. 307:609-613.
49. Unwin, P. N. T., and G. Zampighi. 1980. Structure of the junction between communicating cells. Nature. 283:545-549.
50. Werner, R., E. Levine, C. Rabadan-Diehl, and G. Dahl. 1991. Gating properties of connexin32 cell-cell channels and their mutants expressed in Xenopus oocytes. Proc. R. Soc. Lond. 243:5-11.
51. White, T. W., R. Bruzzone, S. Wolfram, D. L. Paul, and D. A. Goodenough. 1994. Selective interactions among the multiple connexin proteins expressed in the vertebrate lens. the second extracellular domain is a determinant of compatibility between connexins. J. Cell Biol. 125: 879-892.
52. White, T. W., D. L. Paul, D A. Goodenough, and R Bruzzone. 1995. Functional analysis of selective interactions amons rodent connexins. Mol. Biol. Cell 6:459-470.
53. Yamamoto, T., A. Ochalski, E. L. Hertzberg, and J. I. Nagy. 1990. On the organization of astrocytic gap junctions in rat brain as suggested by LM and EM immunochemistry of connexin43 expression. J. Comp. Neurol. 302:853-883.
54. Zagotta, W. N., T. Hoshi, and R. W. Aldnch. 1990. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science. 250.568-571.
55. Zhang, J. T , and B. J. Nicholson. 1994. The topological structure of connexin 26 and its distribution compared to connexin 32 in hepatic gap junctions. J. Membr. Biol. 139:15-29.