Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3506-3518

  Shimizu, K ^a   Schonbeck, U ^a   Mach, F ^a   Libby, P ^a   Mitchell, R N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOSCLEROSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HEART GRAFT; IMMUNE RESPONSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SKIN GRAFT; SPLEEN CELL; T LYMPHOCYTE;

EID: 0034665321     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3506     Document Type: Article

References (43)

1. + T cells
2. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g
3. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
4. The expansive role of CD40 and its ligand, gp39, in immunity
5. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
6. + T cells
7. CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model
8. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis
9. Antibody-induced transplant arteriosclerosis is prevented by graft expression of antioxidant and anti-apoptotic genes
10. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
11. Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody
12. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection
13. Interferon-γ deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts
14. Interferon-γ-secreting T-cell populations in rejecting murine cardiac allografts: Assessment by flow cytometry
15. A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation
16. Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies
17. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: Role of interferon-gamma
18. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
19. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
20. The Th1/Th2 paradigm and the allograft response
21. Cardiac allografts from IL-4 knockout recipients: Assessment of transplant arteriosclerosis and peripheral tolerance
22. IFN-γ is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
23. Evidence for immune regulation in the induction of transplantation tolerance: A conditional but limited role for IL-4
24. Intraoperative estimation of endotoxin, TNF α, and IL-6 in orthotopic liver transplantation and their relation to rejection and postoperative infection
25. Production of cytokines (TNF-α, IL-1-β) and endothelial cell activation in human liver allograft rejection
26. The role of tumor necrosis factor in allograft rejection. I. Evidence that elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation
27. Evaluation of plasma levels of tumour necrosis factor alpha and interleukin-6 as rejection markers in a cohort of 142 heart-grafted patients followed by endomyocardial biopsy
28. Anti-TNF-α treatment down-regulates the expression of fibronectin and decreases cellular infiltration of cardiac allografts in rats
29. Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection
30. + T-helper and a T-killer cell
31. Help for cytotoxic-T-cell responses is mediated by CD40 signalling
32. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
33. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function
34. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts
35. Disruption of CD154:CD40 blocks generation of allograft immunity without affecting APC activation
36. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
37. CD40 and its ligand in host defense
38. CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism
39. The many roles of CD40 in cell-mediated inflammatory responses
40. In the absence of a CD40 signal, B cells are tolerogenic
41. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice
42. Immunobiology of transplantation
43. Effect of major histocompatibility complex matching on the development of tolerance to primarily vascularized renal allografts: A study in miniature swine