메뉴 건너뛰기




Volumn 100, Issue 12, 2002, Pages 4090-4097

CD8αα memory effector T cells descend directly from clonally expanded CD8α+βhigh TCRαβ T cells in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYTOKINE; CYTOTOXIC GRANULE PROTEIN; GRANZYME B; MEMBRANE ANTIGEN; PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CD8ALPHAALPHA ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PERFORIN; PORE FORMING CYTOTOXIC PROTEIN;

EID: 0036882116     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-04-1136     Document Type: Article
Times cited : (54)

References (60)
  • 1
    • 0030926140 scopus 로고    scopus 로고
    • Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2
    • Gao GF, Tormo J, Gerth UC, et al. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997;387:630-634.
    • (1997) Nature , vol.387 , pp. 630-634
    • Gao, G.F.1    Tormo, J.2    Gerth, U.C.3
  • 2
    • 0032006123 scopus 로고    scopus 로고
    • CD4 and CD8: Modulators of T-cell receptor recognition of antigen and of immune responses?
    • Zamoyska R. CD4 and CD8: Modulators of T-cell receptor recognition of antigen and of immune responses? Curr Opin Immunol. 1998;10:82-87.
    • (1998) Curr Opin Immunol , vol.10 , pp. 82-87
    • Zamoyska, R.1
  • 4
    • 0025366452 scopus 로고
    • A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2
    • Salter RD, Benjamin RJ, Wesley PK, et al. A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature. 1990;345:4146.
    • (1990) Nature , vol.345 , pp. 4146
    • Salter, R.D.1    Benjamin, R.J.2    Wesley, P.K.3
  • 5
    • 0023737931 scopus 로고
    • The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosineprotein kinase p56lck
    • Veillette A, Bookman MA, Horak EM, Bolen JB. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosineprotein kinase p56lck. Cell. 1988;55:301-308.
    • (1988) Cell , vol.55 , pp. 301-308
    • Veillette, A.1    Bookman, M.A.2    Horak, E.M.3    Bolen, J.B.4
  • 6
    • 0141807008 scopus 로고
    • The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    • Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE. The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A. 1989;86:3277-3281.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 3277-3281
    • Barber, E.K.1    Dasgupta, J.D.2    Schlossman, S.F.3    Trevillyan, J.M.4    Rudd, C.E.5
  • 7
    • 0030250114 scopus 로고    scopus 로고
    • Complex complexes: Signaling at the TCR
    • Wange RL, Samelson LE. Complex complexes: Signaling at the TCR. Immunity. 1996;5:197-205.
    • (1996) Immunity , vol.5 , pp. 197-205
    • Wange, R.L.1    Samelson, L.E.2
  • 8
    • 0025667227 scopus 로고
    • Differential expression of CD8 alpha and CD8 beta associated with MHC-restricted and non-MHC-restricted cytolytic effector cells
    • Baume DM, Caligiuri MA, Manley TJ, Daley JF, Ritz J. Differential expression of CD8 alpha and CD8 beta associated with MHC-restricted and non-MHC-restricted cytolytic effector cells. Cell Immunol. 1990;131:352-365.
    • (1990) Cell Immunol , vol.131 , pp. 352-365
    • Baume, D.M.1    Caligiuri, M.A.2    Manley, T.J.3    Daley, J.F.4    Ritz, J.5
  • 9
    • 0025820726 scopus 로고
    • Expression of different CD8 isoforms on distinct human lymphocyte subpopulations
    • Moebius U, Kober G, Griscelli AL, Hercend T, Meuer SC. Expression of different CD8 isoforms on distinct human lymphocyte subpopulations. Eur J Immunol. 1991;21:1793-1800.
    • (1991) Eur J Immunol , vol.21 , pp. 1793-1800
    • Moebius, U.1    Kober, G.2    Griscelli, A.L.3    Hercend, T.4    Meuer, S.C.5
  • 10
    • 0024114857 scopus 로고
    • A second subunit of CD8 is expressed in human T cells
    • Norment AM, Littman DR. A second subunit of CD8 is expressed in human T cells. EMBO J. 1988;7:3433-3439.
    • (1988) EMBO J , vol.7 , pp. 3433-3439
    • Norment, A.M.1    Littman, D.R.2
  • 11
    • 0025332456 scopus 로고
    • Differential expression and regulation of the human CD8 alpha and CD8 beta chains
    • Terry LA, DiSanto JP, Small TN, Flomenberg N. Differential expression and regulation of the human CD8 alpha and CD8 beta chains. Tissue Antigens. 1990;35:82-91.
    • (1990) Tissue Antigens , vol.35 , pp. 82-91
    • Terry, L.A.1    DiSanto, J.P.2    Small, T.N.3    Flomenberg, N.4
  • 12
    • 0024582767 scopus 로고
    • Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes: Absence of an intervening sequence between V- and J-like gene segments
    • Nakayama K, Shinkai YI, Okumura K, Nakauchi H. Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes: Absence of an intervening sequence between V- and J-like gene segments. J Immunol. 1989;142:2540-2546.
    • (1989) J Immunol , vol.142 , pp. 2540-2546
    • Nakayama, K.1    Shinkai, Y.I.2    Okumura, K.3    Nakauchi, H.4
  • 13
    • 0024542793 scopus 로고
    • Molecular biology and function of CD4 and CD8
    • Parnes JR. Molecular biology and function of CD4 and CD8. Adv Immunol. 1989;44:265-311.
    • (1989) Adv Immunol , vol.44 , pp. 265-311
    • Parnes, J.R.1
  • 15
    • 0030472888 scopus 로고    scopus 로고
    • CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding
    • Renard V, Romero P, Vivier E, Malissen B, Luescher IF. CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding. J Exp Med. 1996;184:2439-2444.
    • (1996) J Exp Med , vol.184 , pp. 2439-2444
    • Renard, V.1    Romero, P.2    Vivier, E.3    Malissen, B.4    Luescher, I.F.5
  • 16
    • 0032056354 scopus 로고    scopus 로고
    • Mechanisms of CD8beta-mediated T cell response enhancement: Interaction with MHC class I/beta2-microglobulin and functional coupling to TCR/CD3
    • Wheeler CJ, Chen JY, Potter TA, Parnes JR. Mechanisms of CD8beta-mediated T cell response enhancement: Interaction with MHC class I/beta2-microglobulin and functional coupling to TCR/CD3. J Immunol. 1998;160:4199-4207.
    • (1998) J Immunol , vol.160 , pp. 4199-4207
    • Wheeler, C.J.1    Chen, J.Y.2    Potter, T.A.3    Parnes, J.R.4
  • 17
    • 0031858523 scopus 로고    scopus 로고
    • The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development
    • Irie HY, Mong MS, Itano A, et al. The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development. J Immunol. 1998;161:183-191.
    • (1998) J Immunol , vol.161 , pp. 183-191
    • Irie, H.Y.1    Mong, M.S.2    Itano, A.3
  • 18
    • 0028986357 scopus 로고
    • CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity
    • Irie HY, Ravichandran KS, Burakoff SJ. CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity. J Exp Med. 1995;181:1267-1273.
    • (1995) J Exp Med , vol.181 , pp. 1267-1273
    • Irie, H.Y.1    Ravichandran, K.S.2    Burakoff, S.J.3
  • 19
    • 0030296456 scopus 로고    scopus 로고
    • Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome
    • Kawabata K, Nagasawa M, Morio T, Okawa H, Yata J. Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome. Clin Immunol Immunopathol. 1996;81:129-135.
    • (1996) Clin Immunol Immunopathol , vol.81 , pp. 129-135
    • Kawabata, K.1    Nagasawa, M.2    Morio, T.3    Okawa, H.4    Yata, J.5
  • 20
    • 0030765961 scopus 로고    scopus 로고
    • Thymic and extrathymic differentiation and expansion of T lymphocytes following bone marrow transplantation in irradiated recipients
    • Dulude G, Brochu S, Fontaine P, et al. Thymic and extrathymic differentiation and expansion of T lymphocytes following bone marrow transplantation in irradiated recipients. Exp Hematol. 1997;25:992-1004.
    • (1997) Exp Hematol , vol.25 , pp. 992-1004
    • Dulude, G.1    Brochu, S.2    Fontaine, P.3
  • 21
    • 0034021831 scopus 로고    scopus 로고
    • Thymusindependent expansion of T lymphocytes in children after allogeneic bone marrow transplantation
    • Honda K, Takada H, Nagatoshi Y, et al. Thymusindependent expansion of T lymphocytes in children after allogeneic bone marrow transplantation. Bone Marrow Transplant. 2000;25:647-652.
    • (2000) Bone Marrow Transplant , vol.25 , pp. 647-652
    • Honda, K.1    Takada, H.2    Nagatoshi, Y.3
  • 23
    • 0036199258 scopus 로고    scopus 로고
    • Precursors of functional MHC class I- or class II-restricted CD8aa T cells are positively selected in the thymus by agonist self-peptides
    • Leishman AJ, Gapin L, Capone M, et al. Precursors of functional MHC class I- or class II-restricted CD8aa T cells are positively selected in the thymus by agonist self-peptides. Immunity. 2002;16:355-364.
    • (2002) Immunity , vol.16 , pp. 355-364
    • Leishman, A.J.1    Gapin, L.2    Capone, M.3
  • 24
    • 0037090144 scopus 로고    scopus 로고
    • b and thymic leukemia antigen, while similarly with their a3 domains
    • b and thymic leukemia antigen, while similarly with their a3 domains. J Immunol. 2002;168:3881-3886.
    • (2002) J Immunol , vol.168 , pp. 3881-3886
    • Devine, L.1    Rogozinski, L.2    Naidenko, O.V.3
  • 25
    • 0034671607 scopus 로고    scopus 로고
    • Intestinal CD8aa and CD8ab intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCRb repertoires
    • Imhof BA, Dunon D, Courtois D, et al. Intestinal CD8aa and CD8ab intraepithelial lymphocytes are thymus derived and exhibit subtle differences in TCRb repertoires. J Immunol. 2000;165:6716-6722.
    • (2000) J Immunol , vol.165 , pp. 6716-6722
    • Imhof, B.A.1    Dunon, D.2    Courtois, D.3
  • 26
    • 0033831175 scopus 로고    scopus 로고
    • Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
    • Hazenberg MD, Otto SA, Cohen Stuart JW, et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med. 2000;6:1036-1042.
    • (2000) Nat Med , vol.6 , pp. 1036-1042
    • Hazenberg, M.D.1    Otto, S.A.2    Cohen Stuart, J.W.3
  • 28
    • 0033135936 scopus 로고    scopus 로고
    • Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: Evidence for the involvemeni of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia
    • Zeng W, Nakao S, Takamatsu H, et al. Characterization of T-cell repertoire of the bone marrow in immune-mediated aplastic anemia: Evidence for the involvemeni of antigen-driven T-cell response in cyclosporine-dependent aplastic anemia. Blood. 1999;93:3008-3016.
    • (1999) Blood , vol.93 , pp. 3008-3016
    • Zeng, W.1    Nakao, S.2    Takamatsu, H.3
  • 30
    • 0027205203 scopus 로고
    • Human T cells respond to mouse mammary tumor virus-encoded superantigen: V beta restriction and conserved evolutionary features
    • Labrecque N, McGrath H, Subramanyam M, Huber BT, Sekaly RP. Human T cells respond to mouse mammary tumor virus-encoded superantigen: V beta restriction and conserved evolutionary features. J Exp Med. 1993;177:1735-1743.
    • (1993) J Exp Med , vol.177 , pp. 1735-1743
    • Labrecque, N.1    McGrath, H.2    Subramanyam, M.3    Huber, B.T.4    Sekaly, R.P.5
  • 32
    • 0026527127 scopus 로고
    • Isoforms of the CD45 common leukocyte antigen family: Markers for human T-cell differentiation
    • Clement LT. Isoforms of the CD45 common leukocyte antigen family: Markers for human T-cell differentiation. J Clin Immunol. 1992;12:1-10.
    • (1992) J Clin Immunol , vol.12 , pp. 1-10
    • Clement, L.T.1
  • 34
    • 0035865086 scopus 로고    scopus 로고
    • Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis
    • Sempowski G, Thomasch J, Gooding M, et al. Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. J Immunol. 2001;166:2808-2817.
    • (2001) J Immunol , vol.166 , pp. 2808-2817
    • Sempowski, G.1    Thomasch, J.2    Gooding, M.3
  • 35
    • 0034194058 scopus 로고    scopus 로고
    • Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging
    • Fagnoni FF, Vescovini R, Passeri G, et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood. 2000;95:2860-2868.
    • (2000) Blood , vol.95 , pp. 2860-2868
    • Fagnoni, F.F.1    Vescovini, R.2    Passeri, G.3
  • 37
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 39
    • 0035282444 scopus 로고    scopus 로고
    • Skewed maturation of memory HIV-specific CD8 T lymphocytes
    • Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410:106-111.
    • (2001) Nature , vol.410 , pp. 106-111
    • Champagne, P.1    Ogg, G.S.2    King, A.S.3
  • 40
    • 0035576393 scopus 로고    scopus 로고
    • The activatory receptor 2B4 is expressed in vivo by human CD8(+) effector alphabeta T cells
    • Speiser DE, Colonna M, Ayyoub M, et al. The activatory receptor 2B4 is expressed in vivo by human CD8(+) effector alphabeta T cells. J Immunol. 2001;167:6165-6170.
    • (2001) J Immunol , vol.167 , pp. 6165-6170
    • Speiser, D.E.1    Colonna, M.2    Ayyoub, M.3
  • 42
    • 0027251463 scopus 로고
    • The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
    • Pannetier C, Cochet M, Darche S, Casrouge A, Zoller M, Kourilsky P. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc Natl Acad Sci U S A. 1993;90:4319-4323.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4319-4323
    • Pannetier, C.1    Cochet, M.2    Darche, S.3    Casrouge, A.4    Zoller, M.5    Kourilsky, P.6
  • 43
    • 0034462322 scopus 로고    scopus 로고
    • T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children
    • Kou ZC, Puhr JS, Rojas M, McCormack WT, Goodenow MM, Sleasman JW. T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children. Clin Diagn Lab Immunol. 2000;7:953-959.
    • (2000) Clin Diagn Lab Immunol , vol.7 , pp. 953-959
    • Kou, Z.C.1    Puhr, J.S.2    Rojas, M.3    McCormack, W.T.4    Goodenow, M.M.5    Sleasman, J.W.6
  • 44
    • 0031885673 scopus 로고    scopus 로고
    • Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation
    • Kong F, Chen CH, Cooper MD. Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation. Immunity. 1998;8:97-104.
    • (1998) Immunity , vol.8 , pp. 97-104
    • Kong, F.1    Chen, C.H.2    Cooper, M.D.3
  • 45
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
    • Livak F, Schatz DG. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol. 1996;16:609-618.
    • (1996) Mol Cell Biol , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 47
    • 0033966371 scopus 로고    scopus 로고
    • Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism
    • Wu CJ, Chillemi A, Alyea EP, et al. Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism. Blood. 2000;95:352-359.
    • (2000) Blood , vol.95 , pp. 352-359
    • Wu, C.J.1    Chillemi, A.2    Alyea, E.P.3
  • 49
    • 0026502380 scopus 로고
    • Mapping T-cell receptorpeptide contacts by variant peptide immunization of single-chain transgenics
    • Jorgensen JL, Esser U, Fazekas de St Groth B, Reay PA, Davis MM. Mapping T-cell receptorpeptide contacts by variant peptide immunization of single-chain transgenics. Nature. 1992;355:224-230.
    • (1992) Nature , vol.355 , pp. 224-230
    • Jorgensen, J.L.1    Esser, U.2    Fazekas de St Groth, B.3    Reay, P.A.4    Davis, M.M.5
  • 50
    • 0028908698 scopus 로고
    • T-cell repertoire diversity and clonal expansions in normal and clinical samples
    • Pannetier C, Even J, Kourilsky P. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today. 1995;16:176-181.
    • (1995) Immunol Today , vol.16 , pp. 176-181
    • Pannetier, C.1    Even, J.2    Kourilsky, P.3
  • 51
    • 0028220953 scopus 로고
    • Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: Correlation with immune status
    • Gorski J, Yassai M, Zhu X, et al. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: Correlation with immune status. J Immunol. 1994;152:5109-5119.
    • (1994) J Immunol , vol.152 , pp. 5109-5119
    • Gorski, J.1    Yassai, M.2    Zhu, X.3
  • 52
    • 0034610972 scopus 로고    scopus 로고
    • Identical T cell clones are located within the mouse gut epithelium and lamina propria and circulate in the thoracic duct lymph
    • Arstila T, Arstila TP, Calbo S, et al. Identical T cell clones are located within the mouse gut epithelium and lamina propria and circulate in the thoracic duct lymph. J Exp Med. 2000;191:823-834.
    • (2000) J Exp Med , vol.191 , pp. 823-834
    • Arstila, T.1    Arstila, T.P.2    Calbo, S.3
  • 54
    • 0035040110 scopus 로고    scopus 로고
    • Identification of the T cell clones expanding within both CDS(+)CD28(+) and CDS(+)CD28(-) T cell subsets in recipients of allogeneic hematopoietic cell grafts and its implication in post-transplant skewing of T cell receptor repertoire
    • Horiuchi T, Hirokawa M, Kawabata Y, et al. Identification of the T cell clones expanding within both CDS(+)CD28(+) and CDS(+)CD28(-) T cell subsets in recipients of allogeneic hematopoietic cell grafts and its implication in post-transplant skewing of T cell receptor repertoire. Bone Marrow Transplant. 2001;27:731-739.
    • (2001) Bone Marrow Transplant , vol.27 , pp. 731-739
    • Horiuchi, T.1    Hirokawa, M.2    Kawabata, Y.3
  • 55
    • 0030467957 scopus 로고    scopus 로고
    • Thymic and extrathymic T cell development
    • Leclercq G, Plum J. Thymic and extrathymic T cell development. Leukemia. 1996;10:1853-1859.
    • (1996) Leukemia , vol.10 , pp. 1853-1859
    • Leclercq, G.1    Plum, J.2
  • 57
    • 0028210684 scopus 로고
    • Requirement for CD8 beta chain in positive selection of CD8-lineage T cells
    • Nakayama K, Negishi I, Kuida K, et al. Requirement for CD8 beta chain in positive selection of CD8-lineage T cells. Science. 1994;263:1131-1133.
    • (1994) Science , vol.263 , pp. 1131-1133
    • Nakayama, K.1    Negishi, I.2    Kuida, K.3
  • 58
    • 0028358824 scopus 로고
    • Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice
    • Rocha B, Vassalli P, Guy-Grand D. Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice. J Exp Med. 1994;180:681-686.
    • (1994) J Exp Med , vol.180 , pp. 681-686
    • Rocha, B.1    Vassalli, P.2    Guy-Grand, D.3
  • 59
    • 0031202922 scopus 로고    scopus 로고
    • Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes
    • Hamerman JA, Page ST, Pullen AM. Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes. J Immunol. 1997;159:1240-1246.
    • (1997) J Immunol , vol.159 , pp. 1240-1246
    • Hamerman, J.A.1    Page, S.T.2    Pullen, A.M.3
  • 60
    • 0028170171 scopus 로고
    • Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: Evidence for the random emergence of T cells
    • Regnault A, Cumano A, Vassalli P, Guy-Grand D, Kourilsky P. Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: Evidence for the random emergence of T cells. J Exp Med. 1994;180:1345-1358.
    • (1994) J Exp Med , vol.180 , pp. 1345-1358
    • Regnault, A.1    Cumano, A.2    Vassalli, P.3    Guy-Grand, D.4    Kourilsky, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.