CD8β increases CD8 coreceptor function and participation in TCR-ligand binding

Journal of Experimental Medicine

Volumn 184, Issue 6, 1996, Pages 2439-2444

  Renard, Valery ^a   Romero, Pedro ^b   Vivier, Eric ^a   Malissen, Bernard ^a   Luescher, Immanuel F ^b,c  

^a CNRS   (France)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; MONOCLONAL ANTIBODY; PROTOZOAL PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HYBRIDOMA; LIGAND BINDING; MOUSE; NONHUMAN; PHOTOAFFINITY LABELING; PLASMODIUM BERGHEI; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD8; CELL LINE; FLOW CYTOMETRY; H-2 ANTIGENS; HYBRIDOMAS; MICE; PEPTIDE FRAGMENTS; PLASMODIUM BERGHEI; PROTOZOAN PROTEINS; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; THYMOMA; THYMUS NEOPLASMS;

EID: 0030472888     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.6.2439     Document Type: Article

References (27)

1. Janeway, C.A., Jr. 1992. The T cell receptor as a multicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10:645-674.
2. Leahy, D.J. 1995. A structural view of CD4 and CD8. FASEB J. 9:17-25.
3. Gorman, S.D., Y.H. Sun, R. Zamoyska, and J.R. Parnes. 1988. Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. J. Immunol. 140:3646-3653.
4. Leahy, D.J., R. Axel, and W.A. Hendrickson. 1992. Crystal structure of a soluble form of the human T cell coreceptor. Cell. 68:1145-1162.
5. Salter, R.D., R.J. Benjamin, P.K. Wesley, S.E. Buxton, T.P.J. Garrett, C. Clayberger, A.M. Krensky, A.M. Norment, D.R. Littman, and P. Parham. 1990. A binding site of the T-cell co-receptor CD8 on the α3 domain of HLA-2. Nature (Lond.). 345:41-46.
6. Connolly, J.M., T.H. Hansen, A.L. Ingold, and T.A. Potter. 1990. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I α3 domain: CD8 and the T-cell receptor recognize the same class I molecule. Proc. Natl. Acad. Sci. USA. 87:2137-2141.
7. lck. Cell. 55:301-308.
8. Hoeveler, A., and B. Malissen. 1993. The cysteine residues in the cytoplasmic tail of CD8 α are required for its coreceptor function. Mol. Immunol. 30:755-764.
9. Acres, R.B., P.J. Conlon, D.Y. Mochizuki, and B. Gallis. 1987. Phosphorylation of the CD8 antigen on cytotoxic human T cells in response to phorbol myristate acetate or antigen-presenting B cells. J. Immunol. 139:2268-2274.
10. Wheeler, C.J., P. von Hoegen, and J.R. Parnes. 1992. An immunological role for the CD8 β-chain. Nature (Lond.). 357:247-249.
11. Karaki, S., M. Tanabe, H. Nakauchi, and M. Takiguchi. 1992. β-chain broadens range of CD8 recognition for MHC class I molecule. J. Immunol. 149:1613-1618.
12. Nakayama, K.-I., K. Nakayama, I. Negishi, K. Kuida, M.C. Louie, O. Kanagawa, H. Nakauchi, and D.Y. Loh. 1994. Requirement for CDS β chain in positive selection of CD8-lineage T cells. Science (Wash. DC). 263:1131-1133.
13. Crooks, M.E., and D.R. Littman. 1994. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain. Immunity. 1:277-285.
14. Itano, A., D. Cado, F.K.M. Chan, and E. Robey. 1994. A role for the cytoplasmic tail of the β chain of CD8 in thymic selection. Immunity. 1:287-290.
15. Ine, Y.H., K.S. Ravichandran, and S.J. Burakoff. 1995. CD8β chain influences CD8α chain-associated lck kinase activity. J. Exp. Med. 181:1267-1273.
16. Luescher, I.F., J.-C. Cerottini, and P. Romero. 1994. Photoaffinity labeling of the T cell receptor on cloned cytotoxic T lymphocytes by covalent photoreactive ligand. J. Biol. Chem. 269:5574-5582.
17. d-restricted cloned CTL specific for a photoreactive peptide derivative. Immunity. 3: 51-63.
18. d-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative. Labeling of the α-chain correlates with Jα segment usage. J. Exp. Med. 177:1247-1256.
19. Luescher, I.F., E. Vivier, A. Layer, J. Mahiou, F. Godeau, B. Malissen, and P. Romero. 1995. CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature (Lond.). 373:353-356.
20. Schmidt-Ullrich, R., and K. Eichmann. 1990. Transfection of the CD8 α gene restores specific target cell lysis: factors that determine the function and the expression of CD8 in a cytotoxic T cell clone. Int. Immunol. 2:247-256.
21. Anjuère, F., A. Layer, J.-C. Cerottini, C. Servis, and I.F. Luescher. 1995. Synthesis of a radioiodinated photoreactive MAGE-1 peptide derivative and photoaffinity labeling of cell-associated human leukocyte antigen-A1 molecules. Anal. Biochem. 229:61-67.
22. Gaben, J., C. Langlet, R. Zamoyska, J.R. Parnes, A.M. Schmitt-Verhulst, and B. Malissen. 1987. Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes. Cell. 50:545-554.
23. Malissen, B., M.P. Price, J.M. Goverman, M. McMillan, J. White, J. Kappler, P. Marrack, A. Pierres, M. Pierres, and L. Hood. 1984. Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines. Cell. 36:319-327.
24. O'Rourke, A.M., J. Rogers, and M.F. Mescher. 1990. Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling. Nature (Lond.). 346:187-189.
25. Suzuki, S., J. Kupsch, K. Eichmann, and M.K. Saizawa. 1992. Biochemical evidence of the physical association of the majority of CD3 δ chains with the accessory/coreceptor molecules CD4 and CD8 on nonactivated T lymphocytes. Eur. J. Immunol. 22:2475-2479.
26. Beyers, A.D., L.L. Spruyt, and A.F. Williams. 1992. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA. 89:2945-2949.
27. lck/CD4 to the activated T cell receptor/CD3/ζ complex. J. Exp. Med. 181: 1997-2006.