Tumor detection and visualization using cyanine fluorochrome-labeled antibodies

Biotechnology Progress

Volumn 13, Issue 5, 1997, Pages 649-658

  Ballou, Byron ^a,b,c   Fisher, Gregory W ^a   Hakala, Thomas R ^b,c   Farkas, Daniel L ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; FLUORESCENCE; LIGHT ABSORPTION; LIGHT SCATTERING; MONOCLONAL ANTIBODIES; NITROGEN COMPOUNDS; TISSUE;

FLUOROCHROMES;

ONCOLOGY;

CARBOCYANINE; DIAGNOSTIC AGENT; FLUORESCENT DYE; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; HUMAN; NEOPLASM; SENSITIVITY AND SPECIFICITY;

ANIMALS; ANTIBODIES, MONOCLONAL; CARBOCYANINES; FLUORESCENT DYES; HUMANS; NEOPLASMS; SENSITIVITY AND SPECIFICITY;

EID: 0031239968     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp970088t     Document Type: Article

References (91)

1. Aftab, F.; Stoldt, H. S.; Testori, A.; Imperatori, A.; Chinol, M.; Paganelli, G.; Geraghty, J. Radioimmunoguided surgery and colorectal cancer. Eur. J. Surg. Oncol. 1996, 22, 381-388.
2. Arnold, M. W.; Schneebaum, S.; Berens, A.; Petty, L.; Mojizisik, C.; Hinkle, G.; Martin, E. W., Jr. Intraoperative detection of colorectal cancer with radioimmunoguided surgery and CC49, a second-generation monoclonal antibody. Ann. Surg. 1992, 216, 627-632.
3. Ballou, B.; Jaffe, R.; Taylor, R. J.; Solter, D.; Hakala, T. R. Tumor radioimmunolocation: differential antibody retention by antigenic normal tissue and tumor. J. Immunol. 1984, 132, 2111-2116.
4. Ballou, B.; Reiland, J. M.; Levine, G.; Taylor, R. J.; Shen, W.-C.; Ryser, H. J.-P.; Solter, D.; Hakala, T. R. Tumor location and drug targeting using a monoclonal antibody (anti-SSEA-1) and antigen-binding fragments. J. Surg. Oncol. 1986, 31, 1-12.
5. Ballou, B.; Hellyer, S. K.; Reiland, J. M.; Hakala, T. R. Selection of antigenic specificities suitable for in vivo tumor targeting. Hybridoma 1987, 6, 230.
6. Ballou, B.; Jaffe, R.; Persiani, S.; Shen, W.-C.; Langone, J. J.; Sands, H.; Reiland, J. M.; Curley, J.; Hakala, T. R. Tissue localization of methotrexate-monoclonal IgM immunoconjugates: anti-SSEA-1 and MOPC 104E in mouse teratocarcinomas and normal tissues. Cancer Immunol. Immunother. 1992, 35, 251-256.
7. Ballou, B.; Fisher, G.; Waggoner, A. S.; Farkas, D. L.; Reiland, J. M.; Hakala, T. R. Tumor labeling in vivo using Cy5-monoclonal antibody. Proc. Am. Assoc. Cancer Res. 1994, 35, 504.
8. Ballou, B.; Fisher, G. W.; Waggoner, A. S.; Farkas, D. L.; Reiland, J. M.; Jaffe, R.; Mujumdar, R. B.; Mujumdar, S. W.; Hakala, T. R. Tumor labeling in vivo using cyanine-conjugated monoclonal antibodies. Cancer Immunol. Immunother. 1995a, 41, 257-263.
9. Ballou, B.; Fisher, G. W.; Deng, J.-S.; Farkas, D. L.; Hakala, T. R.; Srivastava, M. Cell surface expression of xenogeneic nucleolin in transfects and heterokaryons. Proc. Am. Soc. Cell Biol. 1995b, 35, 2451.
10. Ballou, B.; Fisher, G. W.; Deng, J.-S.; Reiland, J. M.; Hakala, T. R.; Srivastava, M.; Farkas, D. L. Three-dimensional imaging of nucleolin trafficking in normal cells, transfectants, and heterokaryons. SPIE Proc. 1996, 2680, 123-131.
11. Ballou B. T.; Fisher G. W.; Hakala T. R.; Farkas D. L. Fluorochromes for tumor imaging in vivo. Cancer Detect. Prev. 1997, in press.
12. Bodey, B.; Siegel, S. E.; Kaiser, H. E. Human cancer detection and immunotherapy with conjugated and non-conjugated monoclonal antibodies. Anticancer Res. 1996, 16, 661-674.
13. Buchsbaum, D. J. Experimental approaches to increase radiolabeled antibody localization in tumors. Cancer Res. 1995, 55, 5729s-5732s.
14. Burak, W. E., Jr.; Schneebaum, S.; Kim, J. A.; Arnold, M. W.; Hinkle, G.; Berens, A.; Mojzisik, C.; Martin, E. W., Jr. Pilot study evaluating the intraoperative localization of radiolabeled monoclonal antibody cc83 in patients with metastatic colorectal carcinoma. Surgery 1995, 118, 103-108.
15. Clauss, M. A.; Jain, R. A. Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues. Cancer Res. 1990, 50, 3487-3492.
16. Cobb, L. M. Intratumour factors influencing the access of antibody to tumour cells. Cancer Immunol. Immunother. 1989, 28, 235-240.
17. Epstein, A. L.; Chen, F. M.; Taylor, C. R. A novel method for the detection of necrotic lesions in human cancers. Cancer Res. 1988, 48, 5842-5848.
18. Epstein, A. L.; Khawli, L. A.; Hornick, J. L.; Taylor, C. R. Identification of a monoclonal antibody, TV-1, directed against the basement membrane of tumor vessels, and its use to enhance the delivery of macromolecules to tumors after conjugation with interleukin 2. Cancer Res. 1995, 55, 2673-2680.
19. Farkas, D. L.; Ballou, B. T.; Fisher, G. W.; Taylor, D. L. From in vitro to in vivo by dynamic multiwavelength imaging. SPIE Proc. 1995, 2388, 138-149.
20. Farkas, D. L.; Ballou, B. T.; Fisher, G. W.; Fishman, D.; Garini, Y.; Niu, W.; Wachman, E. S. Microscopic and mesoscopic spectral bio-imaging. SPIE Proc. 1996, 2678, 200-209.
21. Farkas, D. L.; Ballou, B. T.; Fisher, G. W.; Lau, C.; Levenson, R. M.; Wachman, E. S. Optical image acquisition, analysis and processing for biomedical applications. Comput. Med. Imaging Graphics (Special Issue on Biomedical Applications; Del Bimbo, A., Ed.) 1997, in press.
22. Farrel, T. J.; Patterson, M. S.; Wilson, B. C. A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the non-invasive determination of tissue optical properties in vivo. Med. Phys. 1992, 19, 879-888.
23. Fisher, G. W.; Ballou, B.; Deng, J.-S.; Hakala, T. R.; Srivastava, M.; Farkas, D. L. Far-red fluorescence-based high specificity tumor imaging in vivo. Biophys. J. 1996, 70, 343.
24. Folli, S.; Wagnieres, G.; Pelegrin, A.; Calmes, J.-M.; Braichotte, D.; Buchegger, F.; Chaladon, Y.; Hardman, N.; Heusser, C.; Givel, J.-C.; Chapus, G.; Chatelain, A.; van der Bergh, H.; Mach, J.-P. Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 7973-77.
25. Folli, S.; Westerman, P.; Braichotte, D.; Pelegrin, A.; Wagnieres, G.; van den Bergh, H.; Mach, J.-P. Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice. Cancer Res. 1994, 54, 2643-2649.
26. Fujimori, K.; Covell, D. G.; Fletcher, J. E.; Weinstein, J. N. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab′)2, and Fab in tumors. Cancer Res. 1989, 49, 5656-5663.
27. Gadina, M.; Newton, D. L.; Rybak, S. M.; Wu, Y. N.; Youle, R. J. Humanized immunotoxins. Therapeutic Immunol. 1994, 1, 59-64.
28. Gardner, C. M.; Jacques, S. L.; Welch, A. J. Light transport in tissue: accurate expressions for one-dimensional fluence rate and escape function based upon Monte Carlo simulation. Lasers Surg. Med. 1996, 18, 129-138.
29. Goldenberg, D. M. and Larson, S. M. Radioimmunodetection in cancer identification. J. Nucl. Med. 1992, 33, 803-814.
30. Goldenberg, D. M.; Larson, S. M.; Reisfeld, R. A.; Schlom, J. Targeting cancer with radiolabeled antibodies. Immunol. Today 1995, 16, 261-264.
31. Greiner, J. W.; Guadagni, F.; Roselli, M.; Nieroda, C. A. Novel approaches to tumor detection and therapy using a combination of monoclonal antibody and cytokine. Anticancer Res. 1996, 16, 2129-2133.
32. Hall, S. H. Monoclonal antibodies at age 20: promise at last? Science 1995, 270, 915-916.
33. Harris, W. J. Production of humanized monoclonal antibodies for in vivo imaging and therapy. Biochem. Soc. Trans. 1995, 23, 1035-1038.
34. Harrison, K. A.; Tempero, M. A. Diagnostic use of radiolabeled antibodies for cancer. Oncology 1995, 9, 625-631.
35. Hellstrom, I.; Trail, P.; Siegall, C.; Firestone, R.; Hellstrom, K. E. Immunoconjugates and immunotoxins for therapy of solid tumors. Cancer Chemother. Pharmacol. 1996, 38, S35-36.
36. Hoang-Xuan, K.; Delattre, J. Y. Biological and monoclonal antibody therapy for high-grade glioma. Bailleres Clin. Neurol. 1996, 5, 395-411.
37. Hu, P. S.; Hornick, J. L.; Glasky, M. S.; Yun, A. Y.; Milkie, M. N.; Khawli, L. A.; Anderson, P. M.; Epstein, A. L. A Chimeric lym-1/interleukin 2 fusion protein for increasing tumor vascular permeability and enhancing antibody uptake. Cancer Res. 1996, 56, 4998-5004.
38. Huang, X. M.; Molema, G, King, S.; Watkins, L.; Edgington, T. S.; Thorpe, P. E. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 1997, 275, 547-550.
39. Iwahashi, T.; Okochi, E.; Ariyoshi, K.; Watabe, H.; Amann, E.; Mori, S.; Tsuruo, T.; Ono, K. Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model. Cancer Res. 1993, 53, 5475-5482.
40. Jain, R. K. Determinants of tumor blood flow: a review. Cancer Res. 1988, 48, 5471-5481.
41. Jain, R. K. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res. 1990, 50, 814s-819s.
42. Jain, R. K. Physiological resistance to the treatment of solid tumors. In Drug Resistance in Oncology; Teicher, B. A., Ed.; New York: Marcel Dekker, Inc., 1993, pp 87-105.
43. Jurcic, J. G.; Scheinberg, D. A.; Houghton, A. N. Monoclonal antibody therapy of cancer. Cancer Chemother. Biol. Response Modif. 1996, 16, 168-188.
44. Juweid, M.; Neumann, R.; Paik, C.; Perez-Bacete, M. J.; Sato J.; van Osdol, W.; Weinstein, J. N. Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res. 1992, 52, 5144-5153.
45. Khawli, L. A.; Glasky, M. S.; Alauddin, M. M.; Epstein, A. L. Improved tumor localization and radioimaging with chemically modified monoclonal antibodies. Cancer Biother. Radiopharm. 1996, 11, 203-215.
46. Lin, K.; Nagy, J. A.; Xu, H.; Shockley, T. R.; Yarmush, M. L.; Dvorak, H. F. Compartmental distribution of tumor-specific monoclonal antibodies in human melanoma xenografts. Cancer Res. 1994, 54, 2269-2277.
47. Mann, B. D.; Cohen, M. B.; Saxton, R. E.; Morton, D. L.; Benedict, W. F.; Korn, E. L.; Spolter, L.; Graham, L. S.; Chang, C. C.; Burk, M. W. Imaging of human tumor xenografts in nude mice with radiolabeled monoclonal antibodies. Cancer 1984, 54, 1318-1327.
48. Matzku, S. Monoclonal antibodies in tumor therapy. Recent Results Cancer Res. 1996, 141, 1-8.
49. McCready, D. R.; Balch, C. M.; Fidler, I. J.; Murray, J. L. Lack of comparibility between binding of monoclonal antibodies to melanoma cells in vitro and localization in vivo. J. Natl. Cancer Inst. 1989, 81, 682-687.
50. Miller, G. K.; Naeve, G. S.; Gaffar, S. A.; Epstein, A. L. Immunologic and biochemical analysis of TNT-1 and TNT-2 monoclonal antibody binding to histones. Hybridoma 1993, 12, 689-698.
51. Molema, G.; Deleij, L. F. M. H.; Meijer, D. K. F. Tumor vascular endothelium-barrier or target in tumor directed drug delivery and immunotherapy. Pharmaceut. Res. 1997, 14, 2-10.
52. Morgan, A. C.; Galloway, D. R.; Reisfeld, R. A. Production and characterization of monoclonal antibody to a melanoma specific glycoprotein. Hybridoma 1981, 1, 27-36.
53. Mujumdar, R. B.; Ernst, L. A.; Mujumdar, S. R.; Lewis, C. J.; Waggoner, A. S. Cyanine labeling reagents: sulfoindocyanine succinimidyl esters. Bioconjugate Chem. 1993, 4, 105-111.
54. Mujumdar, S. R.; Mujumdar, R. B.; Grant, C. M.; Waggoner, A. S. Cyanine labeling reagents: sulfobenzindocyanine succimimidyl esters. Bioconjugate Chem. 1996, 7, 356-362.
55. Nabi, H. A. Antibody imaging in breast cancer. Semin. Nucl. Med. 1997, 27, 30-39.
56. Norrgren, K.; Strand, S. E.; Nilsson, R.; Lindgren, L.; Sjogren, H. O. A general, extracorporeal immunoadsorption method to increase the tumor-to-normal tissue ratio in radioimmunoimaging and radioimmunotherapy. J. Nucl. Med. 1993, 34, 448-454.
57. Pasqualini, R.; Ruoslahti, E. Organ targeting in vivo using phage display peptide libraries. Nature 1996, 380, 364-366.
58. Pastan, I.; Pai, L. H.; Brinkmann, U.; Fitzgerald, D. Recombinant immunotoxins. Breast Cancer Res. Treatment. 1996, 38, 3-9.
59. Pelegrin, A.; Folli, S.; Bucchegger, F.; Mach, J.-P.; Wagnieres, G.; van der Bergh, H. Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice. Cancer 1991, 67, 2529-2537.
60. Pimm, M. V. Possible consequences of human antibody responses on the biodistribution of fragments of human, humanized or chimeric monoclonal antibodies: a note of caution. Life Sci. 1994, 55, 5-9.
61. Raderer, M.; Becherer, A.; Kurtaran, A.; Angelberger, P.; Li, S.; Leimer, M.; Weinlaender, G.; Kornek, G.; Kletter, K.; Scheithauer, W.; Virgolini, I. Comparison of iodine-123-vasoactive intestinal peptide receptor scintigraphy and indium-111-CYT-103 immunoscintigraphy. J. Nucl. Med. 1996, 37, 1480-1487.
62. Reintgen, D. S.; Shimizu, K.; Coleman, E.; Briner, W.; Kitzmiller, J.; Eisenbarth, G.; Seigler, H. F. Immunodiagnosis of tumors in vivo using radiolabeled monoclonal antibody A2B5. J. Surg. Oncol. 1983, 23, 205-211.
63. Reisfeld, R. A.; Gillies, S. D. Antibody-interleukin 2 fusion proteins: a new approach to cancer therapy. J. Clin. Lab. Anal. 1996, 10, 160-166.
64. Rodwell, J. D.; Alvarez, V. L.; Lee, C.; Lopes, A. D.; Goers, J. W.; King, H. D.; Powsner, H. J.; McKearn, T. J. Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations. Proc. Nat. Acad. Sci. U.S.A. 1986, 83, 2632-2636.
65. Russ, J. C. In The Image Processing Handbook, 2nd ed.; CRC Press: Boca Raton, FL, 1995.
66. Sands, H. Experimental studies of radioimmunodetection of cancer: An overview. Cancer Res. 1990, 50, 809s-813s.
67. Scott, J. K.; Smith, G. P. Searching for peptide ligands with an epitope library. Science 1990, 249, 386-390.
68. Semenkovich, C. F.; Ostlund, R. E., Jr.; Olson, M. O.; Yang, J. W. A protein partially expressed on the surface of HepG2 cells that binds lipoproteins specifically is nucleolin. Biochemistry 1990, 29, 9708-9713.
69. Sharkey, R. M.; Primus, F. J.; Goldenberg, D. M. Second antibody clearance of radiolabeled antibody in cancer radioimmunodetection. Proc. Natl. Acad. Sci. U.S.A. 1984, 81, 2843-2846.
70. Shen, W-C.; Ballou, B. T.; Ryser, H. J-P.; Hakala, T. R. Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells. Cancer Res. 1986, 46, 3912-3916.
71. Shockley, T. R.; Lin, K.; Nagy, J. A.; Tomkins, R. G.; Yarmush, M. L.; Dvorak, H. F. Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts. Cancer Res. 1992a, 52, 367-376.
72. Shockley, T. R.; Lin, K.; Sung, C.; Nagy, J. A.; Tomkins, R. G.; Dedrick, R. L.; Dvorak, H. F.; Yarmush, M. L. A quantitative analysis of tumor-specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels. Cancer Res. 1992b, 52, 357-366.
73. Shonat, R. D.; Wachman, E. S.; Niu, W.; Koretsky, A. P.; Farkas, D. L. Simultaneous hemoglobin saturation and oxygen tension maps in mouse brain using an AOTF microscope. Biophys. J. 1997, 73, 1223-1231.
74. Southwick, P. L.; Ernst, L. A.; Tauriello, E. W.; Parker, SR.; Mujumdar, R. B.; Mujumdar, S. R.; Clever, H. A.; Waggoner, A. S. Cyanine dye labeling reagents-carboxymethylindocyanine succinimidyl esters. Cytometry 1990, 11, 418-430.
75. Strand, S. E.; Norrgren, K.; Garkavij, M.; Lindgren, L.; Nilsson, R.; Sjogren, H.O.; Tennvall, J. A general extracorporeal immunoadsorption method to increase tumor-to-tissue ratio. Cancer 1994, 73, 1033-1037.
76. Sung, C.; Shockley, T. R.; Morrison, P. F.; Dvorak, H. F.; Yarmush, M. L.; Dedrick, R. L. Predicted and observed effects of antibody affinity and antigen density on monoclonal antibody uptake in solid tumors. Cancer Res. 1992, 52, 377-384.
77. Valkema, R.; Steens, J.; Cleton, F. J.; Pauwels, E. K. The diagnostic utility of somatostatin receptor scintigraphy in oncology. Cancer Res. Clin. Oncol. 1996, 122, 513-532.
78. van Assendelft, O. W. In Spectrophotometry of haemoglobin derivatives; C. C. Thomas/Royal Vangorcum LTD: The Netherlands, 1970; pp 55-60.
79. van Holde, K. E. Scattering. In Physical Biochemistry; Prentice-Hall: London, 1971; pp 182-183.
80. van Osdol, W.; Fujimori, K.; Weinstein J. N. An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier". Cancer Res. 1991, 57, 4776-4784.
81. Vogel, C. A.; Galmiche, M. C.; Westermann, P.; Sun L. Q.; Pelegrin, A.; Folli, S.; Delaloye, A. B.; Slosman, D. O.; Mach, J. P.; Buchegger, F. Carcinoembryonic antigen expression, antibody localisation and immunophotodetection of human colon cancer liver metastases in nude mice-a model for radioimmunotherapy. Int. J. Cancer 1996, 67, 294-302.
82. Wachman, E. S.; Niu, W.; Farkas, D. L. AOTF microscope for imaging with increased speed and spectral versatility. Biophys. J. 1997, 73, 1215-1222.
83. Waggoner, A. S.; Ernst, L. A. Fluorescent reagents for flow cytometry. In Clinical Flow Cytometry: Principles and Applications; Bauer, K. D., Duque, R. E., Shankey, T. V., Eds.; Williams and Wilkins: Baltimore, MD, 1993; pp 111-116.
84. Waldmann, T. A. Monoclonal antibodies in diagnosis and therapy. Science 1991, 252, 1657-1662.
85. Weinstein, J. N.; van Osdol, W. Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier". Cancer Res. 1992, 52, 2747s-2751s.
86. Weinstein, J. N.; Eger, R. R.; Covell, D. G.; Black, C. D.; Mulshine, J.; Carrasquillo, J. A.; Larson, S. M.; Keenan, A. M. The pharmacology of monoclonal antibodies. Ann. N.Y. Acad. Sci. 1987, 507, 199-210.
87. Wessendorf, M. W.; Brelje, T. C. Which fluorophore is brightest? A comparison of the staining obtained using fluorescein, tetramethylrhodamine, lissamine rhodamine, Texas red, and cyanine 3.18. Histochemistry 1992, 98, 81-85.
88. Yeh, T. T-cell tracking by magnetic resonance imaging: a potentially non-invasive approach to detect the early acute rejection of organ transplantation in vivo. Ph.D. dissertation, Department of Biological Sciences, Carnegie Mellon University, 1995; pp 194-197.
89. Yokota, T.; Milenic, D. E.; Whitlow, M.; Schlom, J. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 1992, 52, 3402-3408.
90. Youle, R. J. Immunotoxins for central nervous system malignancy. Sem. Cancer Biol. 1996, 7, 65-70.
91. Zuckier, L. S.; Denardo, G. L. Trials and tribulations-oncological antibody imaging comes to the fore. Semin. Nucl. Med. 1997, 27, 10-29.