In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET)

Nature Biotechnology

Volumn 18, Issue 6, 2000, Pages 655-660

  Kornblum, Harley I ^a   Araujo, Dalia M ^a   Annala, Alexander J ^a   Tatsukawa, Keith J ^a   Phelps, Michael E ^a   Cherry, Simon R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain; Glucose metabolism; Hemispherectomy; Seizure; Vibrissal stimulation

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; IMAGING SYSTEM; NEOCORTEX; NEOSTRIATUM; NERVE CELL PLASTICITY; NERVE CONDUCTION; NERVE FUNCTION; NERVE REGENERATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; THALAMUS;

AGE FACTORS; ANIMALS; ANIMALS, LABORATORY; BRAIN; DISEASE MODELS, ANIMAL; EPILEPSY; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE; HIPPOCAMPUS; MALE; NEOCORTEX; NEURONAL PLASTICITY; NEURONS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED;

ANIMALIA; RODENTIA;

EID: 0034131219     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/76509     Document Type: Article

References (45)

1. 14C]deoxyglucose. Science 187, 850-853 (1975).
2. Schwartz, W.J. et al. Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science 205, 723-725 (1979).
3. Greer, C.A., Stewart, W.B., Kauer, J.S. & Shepherd, G.M. Topographical and laminar localization of 2-deoxyglucose uptake in rat olfactory bulb induced by electrical stimulation of olfactory nerves. Brain Res. 217, 279-293 (1981).
4. Chugani, H.T., Hovda, D.A., Villablanca, J.R., Phelps, M.E. & Xu, W.F. Metabolic maturation of the brain: a study of local cerebral glucose utilization in the developing cat. J Cereb. Blood Flow Metab. 11, 35-47 (1991).
5. Bruehl, C. & Witte, O.W. Cellular activity underlying altered brain metabolism during focal epileptic activity. Ann. Neurol. 38, 414-420 (1995).
6. 14C]2-deoxy-D-glucose autoradiography. J. Cereb. Blood Flow Metab. 16, 134-146 (1996).
7. 14C-deoxyglucose studies. Life Sci. 27, 855-862 (1980).
8. Ben-Ari, Y., Tremblay, E., Riche, D., Ghilini, G. & Naquet, R. Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy. Neuroscience 6, 1361-1391 (1981).
9. Albala, B.J., Moshe, S.L. & Okada, R. Kainic-acid-induced seizures: a developmental study. Brain Res. 315, 139-148 (1984).
10. Chugani, H.T. & Jacobs, B. Metabolic recovery in caudate nucleus of children following cerebral hemispherectomy. Ann. Neurol. 36, 794-797 (1994).
11. Iglesias, S. et al. Do changes in oxygen metabolism in the unaffected cerebral hemisphere underlie early neurological recovery after stroke? A positron emission tomography study. Stroke 27, 1192-1199 (1996).
12. Bergsneider, M. et al. Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study [see comments]. J Neurosurg 86, 241-251 (1997).
13. 15O]-water positron emission tomography study. J. Child Neurol. 13, 16-22 (1998).
14. 3. Ann. Neurol. 8, 348-360 (1980).
15. Chugani, H.T., Rintahaka, P.J. & Shewmon, D.A. Ictal patterns of cerebral glucose utilization in children with epilepsy. Epilepsia 35, 813-822 (1994).
16. Melega, W.P. et al. Recovery of striatal dopamine function after acute amphetamine-and methamphetamine-induced neurotoxicity in the vervet monkey. Brain Res. 766, 113-120 (1997).
17. Brownell, A.L. et al. PET and MR studies of experimental focal stroke. J. Comput. Assist. Tomogr. 15, 376-380 (1991).
18. Magata, Y. et al. Noninvasive measurement of cerebral blood flow and glucose metabolic rate in the rat with high-resolution animal positron emission tomography (PET): a novel in vivo approach for assessing drug action in the brains of small animals. Biol. Pharm. Bull. 18, 753-756 (1995).
19. Ouchi, Y. et al. Cholinergic projection from the basal forebrain and cerebral glucose metabolism in rats: a dynamic PET study [see comments]. J. Cereb. Blood Flow Metab. 16, 34-41 (1996).
20. Kuge, Y. et al. Positron emission tomography for quantitative determination of glucose metabolism in normal and ischemic brains in rats: an insoluble problem by the Harderian glands. J. Cereb. Blood Flow Metab. 17, 116-120 (1997).
21. Cherry, S. et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans. Nucl. Sci. 44, 1161-1166 (1997).
22. Chatziioannou, A.F. et al. Performance evaluation of microPET: a high-resolution LSO PET scanner for animal imaging. J. Nucl. Med. 40, 1164-1175 (1999).
23. Chugani, H.T. et al. Surgical treatment of intractable neonatal-onset seizures: the role of positron emission tomography. Neurology 38, 1178-1188 (1988).
24. Chugani, H.T. & Phelps, M.E. Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography. Science 231, 840-843 (1986).
25. Cutler, P.D., Cherry, S.R., Hoffman, E.J., Digby, W.M. & Phelps, M.E. Design features and performance of a PET system for animal research. J. Nucl. Med. 33, 595-604 (1992).
26. Kinahan, P. & Rogers, J. Analytic 3D imager reconstruction using all detected events. IEEE Trans. Nucl. Sci. 36, 964-968 (1989).
27. Qi, J., Leahy, R.M., Cherry, S.R., Chatziioannou, A. & Farquhar, T.H. High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner. Phys. Med. Biol. 43, 1001-1013 (1998).
28. Dietrich, W.D., Ginsberg, M.D., Busto, R. & Smith, D.W. Metabolic alterations in rat somatosensory cortex following unilateral vibrissal removal. J. Neurosci. 5, 874-880 (1985).
29. Kossut, M. Effects of sensory denervation and deprivation on a single cortical vibrissal column studied with 2-deoxyglucose. Physiol. Bohemoslov. 34, 79-83 (1985).
30. Miller, M.W. & Dow-Edwards, D.L. Vibrissal stimulation affects glucose utilization in the trigeminal/somatosensory system of normal rats and rats prenatally exposed to ethanol. J. Comp. Neurol. 335, 283-284 (1993).
31. Dunn-Meynell, A.A. & Levin, B.E. Lateralized effect of unilateral somatosensory cortex contusion on behavior and cortical reorganization. Brain Res. 675, 143-156 (1995).
32. Krynaw, R. Infantile hemiplegia treated by removing one cerebral hemisphere. J. Neurol. Neurosurg. Psychiatry 13, 243-267 (1950).
33. Napieralski, J.A., Butler, A.K. & Chesselet, M.F. Anatomical and functional evidence for lesion-specific sprouting of corticostriatal input in the adult rat. J. Comp. Neurol. 373, 484-497 (1996).
34. Chatziioannou, A. et al. Comparison of 3D maximum a posteriori and filtered backprojection algorithms for high resolution animal imaging with microPET. IEEE Trans. Med. Imag. in press (2000).
35. Moore, A., Cherry, S., Annala, A. & Hovda, D. Quantitative assessment of FDG-PET studies in rat brain using microPET. J. Cereb. Blood Flow Metab. 19(Suppl 1), S764 (1999).
36. Hoffman, E.J., Huang, S.C. & Phelps, M.E. Quantitation in positron emission computed tomography: 1. Effect of object size. J. Comput. Assist. Tomogr. 3, 299-308 (1979).
37. Coyle, J.T. Neurotoxic action of kainic acid. J. Neurochem. 41, 1-11 (1983).
38. Sokoloff, L. et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28, 897-916 (1977).
39. Kolb, B., Gibb, R. & van der Kooy, D. Cortical and striatal structure and connectivity are altered by neonatal hemidecortication in rats. J. Comp. Neurol. 322, 311-324 (1992).
40. Tatsukawa, K., Shields, S. & Kornblum, H. Limited corticostriatal plasticity following hemidecortication in the rat. Soc. Neurosci. Abstr. 23, 1447 (1997).
41. Kolb, B. Recovery from early cortical damage in rats. I. Differential behavioral and anatomical effects of frontal lesions at different ages of neural maturation. Behav. Brain Res. 25, 205-220 (1987).
42. Fowler, J. & Wolf, A. Positron emitter-labeled compounds. in Positron emission tomography and autoradiography. (eds Phelps, M.E., Mazziotta, J. & Schelbert, H.R.) 391-450 (Raven Press, New York; 1986).
43. Phelps, M.E. et al. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann. Neurol. 6, 371-388 (1979).
44. Ackermann, R.F. & Lear, J.L. Glycolysis-induced discordance between glucose metabolic rates measured with radiolabeled fluorodeoxyglucose and glucose. J. Cereb. Blood Flow Metab. 9, 774-785 (1989).
45. Kornblum, H.I., Chugani, H.T., Tatsukawa, K. & Gall, C.M. Cerebral hemidecortication alters expression of transforming growth factor alpha mRNA in the neostriatum of developing rats. Brain Res. Mol. Brain Res. 21, 107-114 (1994).