A new bioassay including a small scale hepatocyte bioreactor for hepato-mediated toxicity testing in a target cell line

International Journal of Artificial Organs

Volumn 25, Issue 10, 2002, Pages 975-984

  Deglmann, Claus J ^a   Metzger, R ^b   Stickel, M ^a   Hoerrlein, S ^b   Schildberg, F W ^a   Koebe, H G ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Cell Control Biomedical Laboratories   (Germany)

Author keywords

Bioreactor; Cyclophosphamide; EAR; Hepatocytes; In vitro; Microphysiometer; Toxicity testing

Indexed keywords

BIOASSAY; BIOCONVERSION; BIOREACTORS; CELLS; CONTROLLED DRUG DELIVERY; TOXICITY;

BIOREACTOR; CELL LINES; CYCLOPHOSPHAMIDE; EXTRACELLULAR ACIDIFICATION RATE; EXTRACELLULAR ACIDIFICATIONS; HEPATOCYTES; IN-VITRO; MICROPHYSIOMETER; SUPERNATANTS; TOXICITY TESTING;

CELL CULTURE;

CYCLOPHOSPHAMIDE; CYTOCHROME P450; MAFOSFAMIDE;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BIOASSAY; BIOREACTOR; BIOTRANSFORMATION; CELL DESTRUCTION; CELL ISOLATION; CELL LINE; CONTROLLED STUDY; CYTOSTASIS; DEVICE; DRUG ACTIVATION; DRUG SCREENING; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MODEL; NONHUMAN; REACTOR MONITORING; REGIONAL PERFUSION; SENSOR; SWINE; TARGET CELL; TOXICITY TESTING;

EID: 0036816175     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880202501012     Document Type: Article

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