Effects of cyclophosphamide and ifosfamide on neuroblastoma cells before and after activation by microsomes

Anticancer Research

Volumn 17, Issue 2 A, 1997, Pages 981-986

  Meyer, Thomas ^a,c   Wierse, Gerhard ^a   Weinrebe, Wolfram ^a   Treuner, Jörn ^b   Niethammer, Dietrich ^a   Bruchelt, Gernot ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b OLGAHOSPITAL   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Acrolein; Cyclophosphamide; Gluthathione; Ifosfamide; Maphosphamide; Microsomes; Neuroblastoma

Indexed keywords

4 HYDROXYIFOSFAMIDE; ACROLEIN; CYCLOPHOSPHAMIDE; DRUG DERIVATIVE; GLUTATHIONE; IFOSFAMIDE; MAFOSFAMIDE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; LIVER MICROSOME; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BIOTRANSFORMATION; CYCLOPHOSPHAMIDE; HUMANS; IFOSFAMIDE; MICROSOMES, LIVER; NEUROBLASTOMA; RATS; RATS, WISTAR; TUMOR CELLS, CULTURED;

EID: 0030935422     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ahmed AR and Hombal SM: Cyclophosphamide (Cytoxan), a review on a relevant pharmacology and clinical uses. J Amer Acad Dermatol 11:1115-1126, 1984.
2. Alien LM and Creaven PJ: Pharmacocinetics of isofosfamide. Clin Pharmacol Ther 17: 492-498, 1975.
3. Bates DJ, Forster AB and Jarman M: The metabolism of Cyclophosphamide by isolated rat hepatocytes. Biochem Pharmacol 22: 3055-3063, 1981.
4. Beaujean F, Hartmann O and Pico J: Incubation of autologus bone marrow graft with ASTA Z 7557: comparitive studies of haepatological reconstitution after purged or nonepurged bone marrow transplantation. Paed Hematol Oncol 4: 105-115, 1987.
5. Brade WP, Secber S and Herdrich K: Experimental and clinical comparitive activity of isofosfamide and Cyclophosphamide. Cancer Chemother Pharmacol 75: suppl 2: 1-9, 1986.
6. Cohen JL and Jao JY: Enzymatic basis of Cyclophosphamide activation by hepatic microsomes of the rat. J Pharmacol Exp Ther 174: 206-210, 1970.
7. Connors TA, Cox PJ, Farmer PB and Foster AB: Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and ifosfamide, Biochem Pharmacol 23: 115- 129, 1974.
8. Crook TR, Souhami RL and McLean AEM: Cytotoxicity, DNA crosslinks and single strand breaks induced by activated cyclophosphamide and acroleln in human leukemia cells. Cancer Res 46: 5029-5034, 1986.
9. Crook TR, Souhami RL and McLean, AEM: Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide. Cancer Res 46:5035-5038, 1986.
10. l0 Gornall AG, Bardawill CJ, David MM: Determination of serum proteins by means of the biuret reaction. J Biol Chem 177: 751-766, 1948.
11. Gorin NC, Douay L, Laporte JP and Lopez JY: Autologous bone marrow transplantation using marrow incubated with Asta Z 7557 in adult acute leukemia. Blood 67: 1367-1376, 1986.
12. Griffith OW: Glutathione and glutathione disulphide. In: Methods of enzymatic analysis 3. Ed. Vol. VIII, (Bergmeyer HU). Weinheim, Verlag Chemie, 1985, pp 521-529.
13. Hartmann O, Benhamou E, Beaujean F, Katifa C and Lejars O: Repeated high-dose chemotherapy followed by purged autologous bone marrow transplantation as consolidation therapy in metastatic neuroblastoma. J CIin Oncol 8: 1205-1211, 1987.
14. Kaizer H, Stuart RK, Brookmeyer R and Beschorner WE: Autologous bone marrow transplantation in acute leukemia: a phase I study of in vitro treatment of marrow with 4hydroperoxycyclophosphamide to purge tumor cells. Blood 65: 1504-1510, 1985.
15. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicty assays. J Immunol Meth 16: 55-63, 1983.
16. Meijer DKF, Keulemans K and Mulder GJ: Isolated perfused rat liver technique. Methods in Enzymology 77: 81-94, 1981.
17. Meyer T: Doctoral thesis, University of Tubingen, faculty of medicine, Tubingen 1993.
18. Miller LL: History of isolated liver perfusion and some still unsolved problems, 1-9 In: Isolated liver perfusion and its applications (Bartosek I Guaitani A and Miller LL), Raven Press, New York. 1973.
19. Murgo AJ and Weinberger BB: Pharmacological bone marrow purging in autologous transplantation: focus on the cydophosphamiue derivates. Crit Rev in Oncol and Hematol 14: 4160, 1993.
20. Nash T: The colorimetric estimation of formaldehyde by means of the Hamzseh reaction. Biochem J 55: 416-421, 1953.
21. Nowrousian MR. Burkerl H, Herdrich K and Pohl J: "Ifosfamid in der Tumortherapie - ein Vergleich mit Cyclophosphamid" product information from the ASTA-Medica AG, 60314 Frankfurt/M, 1993.
22. Rosen EM. Cassady JR. Frantz CN. Kretschmar C, Levely R and Sallan. SE: Neuroblastoma; The joint center for radiation therapy / Dana-Farber Cancer Institute / Children's hospital experience. J Clin Oncol 2:119-732, 1984.
23. Simone JV: The treatment of neuroblastoma, J Clin Onkol 2: 717-718, 1984.
24. Weinrebe W: Doctoral thesis, University of Tubingen, Faculty of Medicine, Tubingen 1989.