Towards in-vitro prediction of an in-vivo cytostatic response of human tumor cells with a fast chemosensitivity assay

Toxicology

Volumn 166, Issue 1-2, 2001, Pages 97-108

  Metzger, R ^a   Deglmann, C J ^b   Hoerrlein, S ^a   Zapf, S ^a   Hilfrich, J ^c  

^a Cell Control Biomedical Laboratories   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Henriettenstiftung Hannover ^*  (Germany)

Author keywords

ATP hydrolysis; ChemoSelect ; Chemosensitivity; Lactic acid

Indexed keywords

4 HYDROXYCYCLOPHOSPHAMIDE; ADENOSINE TRIPHOSPHATE; ANTIINFECTIVE AGENT; ANTIMITOTIC AGENT; CARBONIC ACID DERIVATIVE; CARBOPLATIN; CISPLATIN; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; LACTIC ACID DERIVATIVE; METHOTREXATE; MITOMYCIN; MITOXANTRONE; NAVELBINE; NIMUSTINE; OCETAXEL; PACLITAXEL; UNCLASSIFIED DRUG; VINBLASTINE; VINDESINE;

ADJUVANT CHEMOTHERAPY; ADULT; ANIMAL CELL; ARTICLE; CANCER; CANCER RESISTANCE; CELL ACTIVITY; CELL METABOLISM; CELL RESPIRATION; CHEMOSENSITIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOSTASIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG SCREENING; DRUG SENSITIVITY; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; ONLINE SYSTEM; PREDICTION; PRIORITY JOURNAL; RAT; SOLID TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; NEOPLASMS; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0035860639     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00440-1     Document Type: Article

References (27)

1. Chemotherapy of ovarian cancer directed by the human tumor stem cell assay
2. Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay. Clinical correlation for Cisplatin resistance of ovarian carcinoma
3. In vitro potentiation of radiation cytotoxicity by recombinant interferons in cervical cancer cell lines
4. Effects of cancer chemotherapeutic agents on dehydrogenase activity of human cancer tissue in vitro
5. Future developments in adjuvant systemic therapy of breast cancer
6. Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten year results
7. Evaluation of tetrazolium-based semi-automatic colorimetric assay
8. Individualizing chemotherapy for solid tumors - Is there any alternative?
9. Principles of chemotherapy
10. Biologic heterogeneity of cancer metastases
11. Chemosensitivity of breast cancer lymph node metastasis compared to the primary tumor from individual patients tested in the histoculture drug response assay
12. Characterization of in vitro chemo sensitivity of perioperative human ovarian malignancies by adenosine triphosphate chemo sensitivity analysis
13. Primary bioassay of human tumor stem cells
14. Clinical application of an in vitro chemosensitivity test, the histoculture drug response assay, to urological cancers: Wide distribution of inhibition rates in bladder cancer and renal cell cancer
15. Simultaneous in vitro drug sensitivity testing on tumors from different sites in the same patient
16. Heterogeneity of chemosensitivity in human breast carcinoma: Use of an adenosine triphosphate (ATP) chemiluminescence assay
17. Highly specific prediction of antineoplastic drug resistance with an in vitro assay using suprapharmacologic drug exposures
18. In vitro toxicology in hepatocyte bioreactors-extracellular acidification rate (EAR) in a target cell line indicates hepato-activated transformation of substrates
19. Comparative chemosensitivity profiles in three human breast cancer cell lines with the ATP-Cell viability assay
20. Growth characteristics of nonmalignant cells in the ATP cell viability assay
21. Chemosensitivity testing in gynecologic malignancies and breast cancer
22. Antigen-specific stimulation of cell extracellular acidification by MHC class II-peptide complexes
23. Biosensor based on the energy metabolism of living cells: The physical chemistry and cell biology of extracellular acidification
24. Nerve growth factor stimulates rapid metabolic responses in PC12 cells
25. Measurement of cellular response to toxic agents using a silicon microphysiometer
26. GM-CSF triggers a rapid, glucose dependent extracellular acidification by TF-1 cells: Evidence for sodium/proton antiporter and PKC mediated activation of acid production