Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol

Molecular Pharmacology

Volumn 55, Issue 1, 1999, Pages 102-108

  Forman, Stuart A ^a   Zhou, Qing ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ALCOHOL; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; XENOPUS;

EID: 0032923920     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.1.102     Document Type: Article

References (25)

1. Aguayo LG and Pancetti FC (1994) Modulation of the gamma-aminobutyric acid-A and glycine-activated chloride current in cultured mouse neurons. J Pharmacol Exp Ther 270:61-69.
2. Aracava Y, Froes-Ferrao MM, Pereira EFR and Albuquerque EX (1991) Sensitivity of N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors to ethanol and pyrazole. Ann NY Acad Sci 625:451-472.
3. Auerbach A, Sigurdson W, Chen J and Akk G (1996) Voltage dependence of mouse acetylcholine receptor gating: Different charge movements in di-, mono-and unliganded receptors. J Physiol (London) 494:155-170.
4. Bradley RJ, Peper K and Sterz R (1980) Postsynaptic effects of ethanol at the frog neuromuscular junction. Nature 284:60-62.
5. Bradley RJ, Liu Y, Roper JF and Dilger JP (1994) Effects of ethanol on ACh receptor channel (Abstract). Alcoholism 18:A481.
6. Deitrich RA, Dunwiddie TV, Harris RA and Erwin VG (1997) Mechanism of action of ethanol: Initial central nervous system actions. Pharmacol Rev 41:489-535.
7. Dilger JP, Brett RS and Lesko LA (1991) Effects of isoflurane on acetylcholine receptor channels. 1. Single-channel currents. Mol Pharmacol 41:127-133.
8. Eghball M, Curmi JP, Birnir B and Gage PW (1997) Hippocampla GABA(a) channel conductance increased by diazepam. Nature 388:71-75.
9. Forman SA (1997) Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor pore. Biophys J 72: 2170-2179.
10. Forman SA, Miller KW and Yellen G (1995) A discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol 48:574-581.
11. Forman SA, Righi DL and Miller KW (1989) Ethanol increases agonist affinity for nicotinic receptors from Torpedo. Biochim Biophys Acta 987:95-103.
12. Gage PW (1965) The effects of methyl, ethyl, and n-propyl alcohol on neuromuscular transmission in the rat. J Pharmacol Exp Ther 150:236-243.
13. Leidenheimer NJ and Harris RA (1992) Acute effects of ethanol on GABAA receptor function: Molecular and physiological determinants (Review). Adv Biochem Psychopharmcol 47:269-279.
14. Lingle CJ, Maconochie D and Steinbach JH (1992) Activation of skeletal muscle nicotinic acetylcholine receptors. J Membr Biology 126:195-217.
15. Liu Y, Dilger JP and Vidal AM (1994) Effects of alcohols and volatile anesthetics on the activation of nicotinic acetylcholine receptor channels. Mol Pharmacol 45: 1235-1241.
16. Machu TK and Harris RA (1994) Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes. J Pharmacol Exp Ther 271:898-905.
17. Maconochie DJ and Steinbach JH (1998) The channel opening rate of adult-and fetal-type mouse muscle nicotinic receptors activated by acetylcholine. J Physiol (London) 506:53-72.
18. Nagata K, Aistrup GL, Huang CS, Marszalec W, Song JH, Yeh JZ and Narahashi T (1996) Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol. Neurosci Lett 217:189-193.
19. Sine SM and Steinbach JH (1984) Agonists block currents through acetylcholine receptor channels. Biophys J 46:277-283.
20. Tomaselli GF, McLaughlin JT, Jurman ME, Hawrot E and Yellen G (1991) Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophys J 60:721-727.
21. Tonner PH, Wood SC and Miller KW (1992) Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo? Mol Pharmacol 42:890-897.
22. Wu G, Tonner PH and Miller KW (1994) Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol 45:102-108.
23. Wu G and Miller KW (1994) Ethanol enhances agonist-induced fast desensitization in nicotinic acetylcholine receptors. Biochemistry 33:9085-9091.
24. Zhang Y, Chen J and Auerbach A (1995) Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium. J Physiol (London) 486:189-206.
25. Zhou Q and Lovinger DM (1998) Alcohols potentiate the function of 5-HT3 receptor channels on NCB-20 cells by favoring and stabilizing the open channel state. J Physiol (London) 507:335-352.