Molecular modulation of recombinant rat α1β2γ2 GABA(A) receptor channels by diazepam

Neuroscience Letters

Volumn 256, Issue 3, 1998, Pages 143-146

  Krampfl, K ^a   Lepier, A ^a   Jahn, K ^a   Franke, C ^a   Bufler, J ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Aminobutyric acid receptor channel; Benzodiazepine; Fast application Patch clamp; HEK293 cells; Kinetic; Recombinant receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR;

ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL LINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; HUMANS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 0032515083     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00767-8     Document Type: Article

References (15)

1. Adelsberger H., von Beckerath N., Franke C., Dudel J. A patch-clamp study on a novel γ-aminobutyric acid activated chloride channel of crayfish deep extensor abdominal muscle. Neurosci. Lett. 170:1994;221-224.
2. Bufler J., Franke C., Parnas H., Dudel J. Open channel block by physostigmine and procaine in embryonic-like nicotinic receptors of mouse muscle. Eur. J. Neurosci. 8:1996;677-678.
3. A channel conductance increased by diazepam. Nature. 388:1997;71-75.
4. Franke C., Hatt H., Dudel J. Liquid filament switch for ultra-fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle. Neurosci. Lett. 77:1987;199-204.
5. Franke C., Parnas H., Hovav G., Dudel J. A molecular scheme for the reaction between acetylcholine and nicotinic channels. Biophys. J. 64:1993;339-356.
6. Jahn K., Bufler J., Franke C. Kinetics of AMPA-type glutamate receptor channels in rat caudate-putamen neurones show a wide range of desensitization but distinct recovery characteristics. Eur. J. Neurosci. 10:1998;664-672.
7. A receptor channels. NeuroReport. 8:1997;3443-3446.
8. A channel responses to brief agonist pulses. Neuron. 15:1995;181-191.
9. A receptor microscopic affinity. Neuropharmacology. 35:1996;1383-1392.
10. A receptors open. Neuron. 12:1994;61-71.
11. Mellor, J.R. and Randall, A.D., Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells, J. Physiol., 503.2 (1998) 353-369.
12. A receptors: from subunits to diverse functions. Ion Channels. 4:1996;89-113.
13. Polc P., Haefely W. Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus. Naunyn Schmiedeberg's Arch. Pharmacol. 294:1976;121-131.
14. A benzodiazepine receptors produced in transfected cells. Science. 245:1989;1389-1392.
15. A receptor subunit for benzodiazepine pharmacolopy. Nature. 338:1989;582-585.