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Volumn 13, Issue 5, 2002, Pages 448-452

Latest developments and in vivo use of the Tet system: Ex vivo and in vivo delivery of tetracycline-regulated genes

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; LENTIVIRUS VECTOR; PRISTINAMYCIN; RECOMBINANT DNA; RETROVIRUS VECTOR; STREPTOGRAMIN; TETRACYCLINE; TRANSCRIPTION FACTOR;

EID: 0036810923     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(02)00361-0     Document Type: Review
Times cited : (68)

References (38)
  • 1
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA. 89:1992;5547-5551.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 3
    • 0033514443 scopus 로고    scopus 로고
    • Tet B or not tet B: Advances in tetracycline-inducible gene expression
    • Blau H.M., Rossi F.M. Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc Natl Acad Sci USA. 96:1999;797-799.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 797-799
    • Blau, H.M.1    Rossi, F.M.2
  • 4
    • 0030797223 scopus 로고    scopus 로고
    • Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
    • Baron U., Gossen M., Bujard H. Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res. 25:1997;2723-2729.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2723-2729
    • Baron, U.1    Gossen, M.2    Bujard, H.3
  • 5
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
    • Novel rtTAs were generated by mutagenesis of the original tTA. One of them (rtTA-M2) shows a 10-fold higher affinity for dox than the previous version. Thus, a lower concentration of dox is required to induce rtTA-M2 DNA binding, facilitating its use in vivo.
    • Urlinger S., Baron U., Thellmann M., Hasan M.T., Bujard H., Hillen W. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA. 97:2000;7963-7968. Novel rtTAs were generated by mutagenesis of the original tTA. One of them (rtTA-M2) shows a 10-fold higher affinity for dox than the previous version. Thus, a lower concentration of dox is required to induce rtTA-M2 DNA binding, facilitating its use in vivo.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7963-7968
    • Urlinger, S.1    Baron, U.2    Thellmann, M.3    Hasan, M.T.4    Bujard, H.5    Hillen, W.6
  • 6
    • 18244382853 scopus 로고    scopus 로고
    • Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators
    • This report describes a method to achieve long-term, inducible expression of a target gene in vivo by direct delivery of the tet system to skeletal muscle. The authors used the novel rtTA-M2 transcriptional activator combined with DNA electroinjection-mediated delivery to obtain regulatable expression of therapeutic levels of EPO in mouse.
    • Lamartina S., Roscilli G., Rinaudo C.D., Sporeno E., Silvi L., Hillen W., Bujard H., Cortese R., Ciliberto G., Toniatti C. Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum Gene Ther. 13:2002;199-210. This report describes a method to achieve long-term, inducible expression of a target gene in vivo by direct delivery of the tet system to skeletal muscle. The authors used the novel rtTA-M2 transcriptional activator combined with DNA electroinjection-mediated delivery to obtain regulatable expression of therapeutic levels of EPO in mouse.
    • (2002) Hum Gene Ther , vol.13 , pp. 199-210
    • Lamartina, S.1    Roscilli, G.2    Rinaudo, C.D.3    Sporeno, E.4    Silvi, L.5    Hillen, W.6    Bujard, H.7    Cortese, R.8    Ciliberto, G.9    Toniatti, C.10
  • 7
    • 0033767759 scopus 로고    scopus 로고
    • Streptogramin-based gene regulation systems for mammalian cells
    • This report describes a novel inducible system conceptually based on the tet system, but using a different antibiotic/transcription factor pair. This new system can be combined with the tet system to independently regulate multiple genes.
    • Fussenegger M., Morris R.P., Fux C., Rimann M., von Stockar B., Thompson C.J., Bailey J.E. Streptogramin-based gene regulation systems for mammalian cells. Nat Biotechnol. 18:2000;1203-1208. This report describes a novel inducible system conceptually based on the tet system, but using a different antibiotic/transcription factor pair. This new system can be combined with the tet system to independently regulate multiple genes.
    • (2000) Nat Biotechnol , vol.18 , pp. 1203-1208
    • Fussenegger, M.1    Morris, R.P.2    Fux, C.3    Rimann, M.4    Von Stockar, B.5    Thompson, C.J.6    Bailey, J.E.7
  • 8
    • 0035866183 scopus 로고    scopus 로고
    • Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells
    • Fux C., Moser S., Schlatter S., Rimann M., Bailey J.E., Fussenegger M. Streptogramin- and tetracycline-responsive dual regulated expression of p27(Kip1) sense and antisense enables positive and negative growth control of Chinese hamster ovary cells. Nucleic Acids Res. 29:2001;E19.
    • (2001) Nucleic Acids Res , vol.29 , pp. 19
    • Fux, C.1    Moser, S.2    Schlatter, S.3    Rimann, M.4    Bailey, J.E.5    Fussenegger, M.6
  • 9
    • 0037045408 scopus 로고    scopus 로고
    • Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice
    • This report contains an interesting analysis of the parameters influencing the efficiency of the tet system in transgenic animals.
    • Robertson A., Perea J., Tolmachova T., Thomas P.K., Huxley C. Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice. Gene. 282:2002;65-74. This report contains an interesting analysis of the parameters influencing the efficiency of the tet system in transgenic animals.
    • (2002) Gene , vol.282 , pp. 65-74
    • Robertson, A.1    Perea, J.2    Tolmachova, T.3    Thomas, P.K.4    Huxley, C.5
  • 11
    • 0028897720 scopus 로고
    • Tetracycline-reversible silencing of eukaryotic promoters
    • Deuschle U., Meyer W.K., Thiesen H.J. Tetracycline-reversible silencing of eukaryotic promoters. Mol Cell Biol. 15:1995;1907-1914.
    • (1995) Mol Cell Biol , vol.15 , pp. 1907-1914
    • Deuschle, U.1    Meyer, W.K.2    Thiesen, H.J.3
  • 12
    • 0031740332 scopus 로고    scopus 로고
    • Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
    • Rossi F.M., Guicherit O.M., Spicher A., Kringstein A.M., Fatyol K., Blakely B.T., Blau H.M. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Nat Genet. 20:1998;389-393.
    • (1998) Nat Genet , vol.20 , pp. 389-393
    • Rossi, F.M.1    Guicherit, O.M.2    Spicher, A.3    Kringstein, A.M.4    Fatyol, K.5    Blakely, B.T.6    Blau, H.M.7
  • 13
    • 0032600013 scopus 로고    scopus 로고
    • A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells
    • Freundlieb S., Schirra-Muller C., Bujard H. A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J Gene Med. 1:1999;4-12.
    • (1999) J Gene Med , vol.1 , pp. 4-12
    • Freundlieb, S.1    Schirra-Muller, C.2    Bujard, H.3
  • 15
    • 0035816681 scopus 로고    scopus 로고
    • Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice
    • The authors used tTS (a transcriptional silencer consisting of tetR fused to the KRAB domain from the Kid-1 protein) to suppress leaky expression of an inducible transgene in the absence of inducer. Lung-specific expression of tTS repressed an inducible IL-13 transgene by at least three orders of magnitude, and did not interfere with the ability to induce it.
    • Zhu Z., Ma B., Homer R.J., Zheng T., Elias J.A. Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J Biol Chem. 276:2001;25222-25229. The authors used tTS (a transcriptional silencer consisting of tetR fused to the KRAB domain from the Kid-1 protein) to suppress leaky expression of an inducible transgene in the absence of inducer. Lung-specific expression of tTS repressed an inducible IL-13 transgene by at least three orders of magnitude, and did not interfere with the ability to induce it.
    • (2001) J Biol Chem , vol.276 , pp. 25222-25229
    • Zhu, Z.1    Ma, B.2    Homer, R.J.3    Zheng, T.4    Elias, J.A.5
  • 16
    • 0031040987 scopus 로고    scopus 로고
    • Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
    • Bohl D., Naffakh N., Heard J.M. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat Med. 3:1997;299-305.
    • (1997) Nat Med , vol.3 , pp. 299-305
    • Bohl, D.1    Naffakh, N.2    Heard, J.M.3
  • 17
    • 0036193248 scopus 로고    scopus 로고
    • Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors
    • This report provides the first example of inducible gene delivery to human haematopoietic progenitors ex vivo. The authors delivered the tet system components and an inducible target gene (luciferase) with lentiviral vectors. Different primary cell types such as fibroblasts, lymphocytes, monocytes and haematopoietic progenitors were successfully infected and expressed inducible luciferase. Expression was maintained in vivo for over 20 weeks after transplantation of the engineered cells.
    • Vigna E., Cavalieri S., Ailles L., Geuna M., Loew R., Bujard H., Naldini L. Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors. Mol Ther. 5:2002;252-261. This report provides the first example of inducible gene delivery to human haematopoietic progenitors ex vivo. The authors delivered the tet system components and an inducible target gene (luciferase) with lentiviral vectors. Different primary cell types such as fibroblasts, lymphocytes, monocytes and haematopoietic progenitors were successfully infected and expressed inducible luciferase. Expression was maintained in vivo for over 20 weeks after transplantation of the engineered cells.
    • (2002) Mol Ther , vol.5 , pp. 252-261
    • Vigna, E.1    Cavalieri, S.2    Ailles, L.3    Geuna, M.4    Loew, R.5    Bujard, H.6    Naldini, L.7
  • 18
    • 1842411367 scopus 로고    scopus 로고
    • Highly efficient and sustained gene transfer in adult neurons with a lentivirus vectorm
    • Blomer U., Naldini L., Kafri T., Trono D., Verma I.M., Gage F.H. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vectorm. J Virol. 71:1997;6641-6649.
    • (1997) J Virol , vol.71 , pp. 6641-6649
    • Blomer, U.1    Naldini, L.2    Kafri, T.3    Trono, D.4    Verma, I.M.5    Gage, F.H.6
  • 19
  • 20
    • 0030716959 scopus 로고    scopus 로고
    • Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
    • Kafri T., Blomer U., Peterson D.A., Gage F.H., Verma I.M. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet. 17:1997;314-317.
    • (1997) Nat Genet , vol.17 , pp. 314-317
    • Kafri, T.1    Blomer, U.2    Peterson, D.A.3    Gage, F.H.4    Verma, I.M.5
  • 21
    • 0035163747 scopus 로고    scopus 로고
    • Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat
    • This report describes a strategy to regulate HIV transcription and replication using the tet system. The authors replaced the TAR sequence with multimerized tetO sites and its cognate transactivator, Tat, with rtTA.
    • Verhoef K., Marzio G., Hillen W., Bujard H., Berkhout B. Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat. J Virol. 75:2001;979-987. This report describes a strategy to regulate HIV transcription and replication using the tet system. The authors replaced the TAR sequence with multimerized tetO sites and its cognate transactivator, Tat, with rtTA.
    • (2001) J Virol , vol.75 , pp. 979-987
    • Verhoef, K.1    Marzio, G.2    Hillen, W.3    Bujard, H.4    Berkhout, B.5
  • 23
    • 0036217859 scopus 로고    scopus 로고
    • Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene
    • Lindeberg J., Mattsson R., Ebendal T. Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene. J Neurosci Res. 68:2002;248-253.
    • (2002) J Neurosci Res , vol.68 , pp. 248-253
    • Lindeberg, J.1    Mattsson, R.2    Ebendal, T.3
  • 24
    • 0034567011 scopus 로고    scopus 로고
    • Cell-type-specific and regulatable transgenesis in the adult brain: Adenovirus-encoded combined transcriptional targeting and inducible transgene expression
    • Smith-Arica J.R., Morelli A.E., Larregina A.T., Smith J., Lowenstein P.R., Castro M.G. Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression. Mol Ther. 2:2000;579-587.
    • (2000) Mol Ther , vol.2 , pp. 579-587
    • Smith-Arica, J.R.1    Morelli, A.E.2    Larregina, A.T.3    Smith, J.4    Lowenstein, P.R.5    Castro, M.G.6
  • 27
    • 0034940450 scopus 로고    scopus 로고
    • The Tet-On system in transgenic mice: Inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic β-cells
    • Lottmann H., Vanselow J., Hessabi B., Walther R. The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic β-cells. J Mol Med. 79:2001;321-328.
    • (2001) J Mol Med , vol.79 , pp. 321-328
    • Lottmann, H.1    Vanselow, J.2    Hessabi, B.3    Walther, R.4
  • 28
    • 0034981141 scopus 로고    scopus 로고
    • Regulated expression of the human CFTR gene in epithelial cells
    • Ye L., Chan S., Chow Y.H., Tsui L.C., Hu J. Regulated expression of the human CFTR gene in epithelial cells. Mol Ther. 3:2001;723-733.
    • (2001) Mol Ther , vol.3 , pp. 723-733
    • Ye, L.1    Chan, S.2    Chow, Y.H.3    Tsui, L.C.4    Hu, J.5
  • 29
    • 0033578067 scopus 로고    scopus 로고
    • Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice
    • Xie W., Chow L.T., Paterson A.J., Chin E., Kudlow J.E. Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice. Oncogene. 18:1999;3593-3607.
    • (1999) Oncogene , vol.18 , pp. 3593-3607
    • Xie, W.1    Chow, L.T.2    Paterson, A.J.3    Chin, E.4    Kudlow, J.E.5
  • 31
    • 0034772693 scopus 로고    scopus 로고
    • Rapid generation of a tetracycline-inducible BCR-ABL-defective retrovirus using a single autoregulatory retroviral cassette
    • Dugray A., Geay J.F., Foudi A., Bonnet M.L., Vainchenker W., Wendling F., Louache F., Turhan A.G. Rapid generation of a tetracycline-inducible BCR-ABL-defective retrovirus using a single autoregulatory retroviral cassette. Leukemia. 15:2001;1658-1662.
    • (2001) Leukemia , vol.15 , pp. 1658-1662
    • Dugray, A.1    Geay, J.F.2    Foudi, A.3    Bonnet, M.L.4    Vainchenker, W.5    Wendling, F.6    Louache, F.7    Turhan, A.G.8
  • 32
    • 0034717727 scopus 로고    scopus 로고
    • Targeting of tetracycline-regulatable transgene expression specifically to neuronal and glial cell populations using adenoviral vectors
    • Ralph G.S., Bienemann A., Harding T.C., Hopton M., Henley J., Uney J.B. Targeting of tetracycline-regulatable transgene expression specifically to neuronal and glial cell populations using adenoviral vectors. Neuroreport. 11:2000;2051-2055.
    • (2000) Neuroreport , vol.11 , pp. 2051-2055
    • Ralph, G.S.1    Bienemann, A.2    Harding, T.C.3    Hopton, M.4    Henley, J.5    Uney, J.B.6
  • 34
    • 0033849202 scopus 로고    scopus 로고
    • Gene transfer into individual muscle fibers and conditional gene expression in living animals
    • Sander A., Guth A., Brenner H.R., Witzemann V. Gene transfer into individual muscle fibers and conditional gene expression in living animals. Cell Tissue Res. 301:2000;397-403.
    • (2000) Cell Tissue Res , vol.301 , pp. 397-403
    • Sander, A.1    Guth, A.2    Brenner, H.R.3    Witzemann, V.4
  • 36
    • 0035824107 scopus 로고    scopus 로고
    • Characteristics of adenovirus-mediated tetracycline-controllable expression system
    • Mizuguchi H., Hayakawa T. Characteristics of adenovirus-mediated tetracycline-controllable expression system. Biochim Biophys Acta. 1568:2001;21-29.
    • (2001) Biochim Biophys Acta , vol.1568 , pp. 21-29
    • Mizuguchi, H.1    Hayakawa, T.2
  • 37
    • 0036171329 scopus 로고    scopus 로고
    • Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors
    • Rendahl K.G., Quiroz D., Ladner M., Coyne M., Seltzer J., Manning W.C., Escobedo J.A. Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors. Hum Gene Ther. 13:2002;335-342.
    • (2002) Hum Gene Ther , vol.13 , pp. 335-342
    • Rendahl, K.G.1    Quiroz, D.2    Ladner, M.3    Coyne, M.4    Seltzer, J.5    Manning, W.C.6    Escobedo, J.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.