Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat

Journal of Virology

Volumn 75, Issue 2, 2001, Pages 979-987

  Verhoef, K ^a   Marzio, G ^a   Hillen, W ^a   Bujard, H ^a   Berkhout, B ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; PRIORITY JOURNAL; VIRUS REPLICATION;

BACTERIAL PROTEINS; CELL LINE; CHEMORECEPTORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, VIRAL; GENE PRODUCTS, TAT; HIV-1; HUMANS; MEMBRANE PROTEINS; MUTAGENESIS, INSERTIONAL; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSFECTION; VIRUS REPLICATION;

EID: 0035163747     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.2.979-987.2001     Document Type: Article

References (55)

1. Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells
2. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
3. Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme
4. Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
5. Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances
6. Multiple biological roles associated with the repeat (R) region of the HIV-1 RNA genome
7. Functional analysis of RNA signals in the HIV-1 genome by forced evolution
8. Transactivation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: A quantitative analysis
9. In vivo selection of randomly mutated retroviral genomes
10. Requirements for DNA strand transfer during reverse transcription in mutant HIV-1 virions
11. Genetic instability of live attenuated human immunodeficiency virus type 1 vaccine strains
12. Integration
13. Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism
14. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
15. Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys)
16. A hairpin structure in the R region of the human immunodeficiency virus type 1 RNA genome is instrumental in polyadenylation site selection
17. Genomic structure of an attenuated quasi species of HIV-1 from blood transfusion donor and recipients
18. Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes
19. Human immunodeficiency virus 1 Tat protein binds trans-activating-responsive region (TAR) RNA in vitro
20. Strong human immunodeficiency virus (HIV)-specifc cytotoxic T-lymphocyte activity in Sydney blood bank cohort patients infected with nef-defective HIV type 1
21. HIV-1 tat trans-activation requires the loop sequence within tar
22. Mutational analysis of stem-loops in the RNA packaging signal of the Moloney murine leukemia virus
23. Transcriptional activation by tetracyclines in mammalian cells
24. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
25. Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1
26. Tat is required for efficient HIV-1 reverse transcription
27. The responsiveness of a tetracycline-sensitive expression system differs in different cell lines
28. Human immunodeficiency viruses regulated by alternative trans-activators: Genetic evidence for a novel non-transcriptional function of Tat in virion infectivity
29. The role of the upstream U3 sequences in the pathogenesis of simian immunodeficiency virus-induced AIDS in rhesus monkeys
30. Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus
31. Functional differences between the LTR transcriptional promoters of HIV-1 subtypes A through G
32. Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: Inverse relationship of degree of protection with level of attenuation
33. Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
34. Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene
35. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
36. Comparison of 5′ and 3′ long terminal repeat promoter function in human immunodeficiency virus
37. Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus
38. Premature strand transfer by the HIV-1 reverse transcriptase during strong-stop DNA synthesis
39. The scanning model for translation: An update
40. A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge
41. A general and fast method to generate multiple site directed mutations
42. ELI
43. Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1
44. Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus
45. Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus
46. Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription
47. Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
48. Attenuated retrovirus vaccines and AIDS
49. A second-site mutation that restores replication of a Tat-defective human immunodeficiency virus
50. Determination of the minimal amount of Tat activity required for human immunodeficiency virus type 1 replication
51. LAV revisited: Origins of the early HIV-1 isolates from Institut Pasteur
52. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
53. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus
54. Dox-dependent SIVmac with tetracycline-inducible promoter in the U3 promoter region