-
1
-
-
17444453579
-
Evaluation of orally administered highly variable drugs and drug formulations
-
V. P. Shah, A. Yacobi, W. H. Barr, L. Z. Benet, D. Breimer, M. R. Dobrinska, L. Endrenyi, W. Fairweater, W. Gillespie, M. A. Gonzalez, J. Hooper, A. Jackson, L. J. Lesko, K. K. Midha, P. K. Noonan, R. Patnaik, and R. L. Williams. Evaluation of orally administered highly variable drugs and drug formulations. Pharm. Res. 13:1590-1594 (1996).
-
(1996)
Pharm. Res.
, vol.13
, pp. 1590-1594
-
-
Shah, V.P.1
Yacobi, A.2
Barr, W.H.3
Benet, L.Z.4
Breimer, D.5
Dobrinska, M.R.6
Endrenyi, L.7
Fairweater, W.8
Gillespie, W.9
Gonzalez, M.A.10
Hooper, J.11
Jackson, A.12
Lesko, L.J.13
Midha, K.K.14
Noonan, P.K.15
Patnaik, R.16
Williams, R.L.17
-
2
-
-
0028598601
-
Modes of action of FK506, cyclosporin A, and rapamycin
-
R. Morris. Modes of action of FK506, cyclosporin A, and rapamycin. Transplant. Proc. 26:3272-3275 (1994).
-
(1994)
Transplant. Proc.
, vol.26
, pp. 3272-3275
-
-
Morris, R.1
-
4
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
C. Cordon-Cardo, J. P. O'Brien, D. Casals, L. Rittman-Grauer, J. L. Biedler, M. R. Melamed, and J. R. Bertino. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA 86:695-698 (1989).
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
Rittman-Grauer, L.4
Biedler, J.L.5
Melamed, M.R.6
Bertino, J.R.7
-
5
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
F. Thiebaut, T. Tsuruo, H. Hamada, M. M. Gottesman, I. Pastan, and M. C. Willingham. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA 84:7735-7738 (1987).
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
6
-
-
0027730961
-
Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport
-
P. F. Augustijns, T. P. Bradshaw, L. L. Gan, R. W. Hendren, and D. R. Thakker. Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport. Biochem. Biophys. Res. Com. 197:360-365 (1993).
-
(1993)
Biochem. Biophys. Res. Com.
, vol.197
, pp. 360-365
-
-
Augustijns, P.F.1
Bradshaw, T.P.2
Gan, L.L.3
Hendren, R.W.4
Thakker, D.R.5
-
7
-
-
0027269878
-
Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin
-
T. Hoof, A. Demmer, U. Christians, and B. Tümmler. Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin. Eur. J. Pharm. Mol. Biol. 246:53-58 (1993).
-
(1993)
Eur. J. Pharm. Mol. Biol.
, vol.246
, pp. 53-58
-
-
Hoof, T.1
Demmer, A.2
Christians, U.3
Tümmler, B.4
-
8
-
-
0027095653
-
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
-
S. P. Cole, G. Bhardwaj, J. H. Gerlach, J. E. MacKie, C. E. Gram, K. C. Almquist, A. J. Stewart, E. U. Kurz, A. M. Duncan, and R. G. Deeley. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654 (1992).
-
(1992)
Science
, vol.258
, pp. 1650-1654
-
-
Cole, S.P.1
Bhardwaj, G.2
Gerlach, J.H.3
MacKie, J.E.4
Gram, C.E.5
Almquist, K.C.6
Stewart, A.J.7
Kurz, E.U.8
Duncan, A.M.9
Deeley, R.G.10
-
9
-
-
0031570099
-
Leukotriene C4 secretion from normal murine mast cells by a probenecid-Sensitive and multidrug resistance-associated protein-independent mechanism
-
T. Nguyen and S. Gupta. Leukotriene C4 secretion from normal murine mast cells by a probenecid-Sensitive and multidrug resistance-associated protein-independent mechanism. J. Immunol. 158:4916-4920 (1997).
-
(1997)
J. Immunol.
, vol.158
, pp. 4916-4920
-
-
Nguyen, T.1
Gupta, S.2
-
10
-
-
0030588714
-
Caco-2 monolayers in experimental and theoretical predictions of drug transport
-
P. Artursson, K. Palm, and K. Luthman. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug. Del. Rev. 22:67-84 (1996).
-
(1996)
Adv. Drug. Del. Rev.
, vol.22
, pp. 67-84
-
-
Artursson, P.1
Palm, K.2
Luthman, K.3
-
11
-
-
0025328006
-
Reversal of multidrug resistance by lipophilic drugs
-
E. Hofsli, and J. Nissen-Myer. Reversal of multidrug resistance by lipophilic drugs. Cancer Res. 50:3997-4002 (1990).
-
(1990)
Cancer Res.
, vol.50
, pp. 3997-4002
-
-
Hofsli, E.1
Nissen-Myer, J.2
-
12
-
-
0030953774
-
Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ARD cells
-
S. Gollapudi, C. H. Kim, B. Tram, S. Sangha, and S. Gupta. Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ARD cells. Cancer Chemother. Pharmacol. 40:150-158 (1997).
-
(1997)
Cancer Chemother. Pharmacol.
, vol.40
, pp. 150-158
-
-
Gollapudi, S.1
Kim, C.H.2
Tram, B.3
Sangha, S.4
Gupta, S.5
-
13
-
-
0025311288
-
Epithelial Transport of Drugs in Cell Culture. I: A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco-2) cells
-
P. Artursson. Epithelial Transport of Drugs in Cell Culture. I: A model for studying the passive diffusion of drugs over intestinal absorbtive (Caco-2) cells. J. Pharm. Sci. 79:476-482 (1990).
-
(1990)
J. Pharm. Sci.
, vol.79
, pp. 476-482
-
-
Artursson, P.1
-
14
-
-
0025804183
-
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
-
P. Artursson and J. Karlsson. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Comm. 175:880-885 (1991).
-
(1991)
Biochem. Biophys. Res. Comm.
, vol.175
, pp. 880-885
-
-
Artursson, P.1
Karlsson, J.2
-
15
-
-
0029020035
-
Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: Relationship to absorption in humans
-
B. H. Stewart, O. H. Chan, R. H. Lu, E. L. Reyner, H. L. Schmid, H. W. Hamilton, B. A. Steinbaugh, and M. D. Taylor. Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: Relationship to absorption in humans. Pharm. Res. 12:693-699 (1995)
-
(1995)
Pharm. Res.
, vol.12
, pp. 693-699
-
-
Stewart, B.H.1
Chan, O.H.2
Lu, R.H.3
Reyner, E.L.4
Schmid, H.L.5
Hamilton, H.W.6
Steinbaugh, B.A.7
Taylor, M.D.8
-
16
-
-
0028212392
-
Investigation of rapamycin transport and uptake across absorptive human intestinal cell monolayers
-
V. C. Dias, and R. W. Yatscoff. Investigation of rapamycin transport and uptake across absorptive human intestinal cell monolayers. Clin. Biochem. 27:31-36 (1994).
-
(1994)
Clin. Biochem.
, vol.27
, pp. 31-36
-
-
Dias, V.C.1
Yatscoff, R.W.2
-
17
-
-
0030787532
-
A Human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model
-
F. Delie and W. Rubas. A Human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model. Crit. Rev. Ther. Drug Carr. Sys. 14:221-286 (1997).
-
(1997)
Crit. Rev. Ther. Drug Carr. Sys.
, vol.14
, pp. 221-286
-
-
Delie, F.1
Rubas, W.2
-
18
-
-
0030790290
-
Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells
-
M. M. Nerurkar, N. F. H. Ho, P. S. Burton, T. J. Vidmar, and R. T. Borchardt. Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells. J. Pharm. Sci. 86:813-821 (1997).
-
(1997)
J. Pharm. Sci.
, vol.86
, pp. 813-821
-
-
Nerurkar, M.M.1
Ho, N.F.H.2
Burton, P.S.3
Vidmar, T.J.4
Borchardt, R.T.5
-
19
-
-
0027987065
-
Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers
-
P. Wils, V. Phung-Ba, A. Warnery, D. Lechardeur, S. Raeissi, I. Hidalgo, and D. Scherman. Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem. Pharm. 48:1528-1530 (1994).
-
(1994)
Biochem. Pharm.
, vol.48
, pp. 1528-1530
-
-
Wils, P.1
Phung-Ba, V.2
Warnery, A.3
Lechardeur, D.4
Raeissi, S.5
Hidalgo, I.6
Scherman, D.7
-
20
-
-
0028931885
-
Sequential coexpression of the multidrug resistance genes MRP and mdrl and their products in VP-16 etoposide-selected H60 small cell lung cancer cells
-
I. Brock, D. R. Hipfner, B. S. Nielsen, P. B. Jensen, R. G. Deeley, S. P. Cole, and M. Sehested. Sequential coexpression of the multidrug resistance genes MRP and mdrl and their products in VP-16 etoposide)-selected H60 small cell lung cancer cells. Cancer Res. 55:459-462 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 459-462
-
-
Brock, I.1
Hipfner, D.R.2
Nielsen, B.S.3
Jensen, P.B.4
Deeley, R.G.5
Cole, S.P.6
Sehested, M.7
-
21
-
-
0030950351
-
Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin
-
E. Dolfini, T. Dasdia, G. Arancia, A. Molinari, A. Calcabrini, R. J. Scheper, M. J. Flens, M. B. Gariboldi, and E. Monti. Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin. Br. J. Cancer 76:67-76 (1997).
-
(1997)
Br. J. Cancer
, vol.76
, pp. 67-76
-
-
Dolfini, E.1
Dasdia, T.2
Arancia, G.3
Molinari, A.4
Calcabrini, A.5
Scheper, R.J.6
Flens, M.J.7
Gariboldi, M.B.8
Monti, E.9
-
22
-
-
0029995238
-
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
-
R. Evers, G. J. Zaman, L. van Deemter, H. Jansen, J. Calafat, L. C. Oomen, R. P. Elferink, P. Borst, and A. H. Schinkel. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J. Clin. Invest. 97:1211-1218 (1996).
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 1211-1218
-
-
Evers, R.1
Zaman, G.J.2
Van Deemter, L.3
Jansen, H.4
Calafat, J.5
Oomen, L.C.6
Elferink, R.P.7
Borst, P.8
Schinkel, A.H.9
-
23
-
-
0031043119
-
The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance
-
M. Kavallaris. The role of multidrug resistance-associated protein (MRP) expression in multidrug resistance. Anti-Cancer Drugs 8:17-25 (1997).
-
(1997)
Anti-Cancer Drugs
, vol.8
, pp. 17-25
-
-
Kavallaris, M.1
-
24
-
-
9044252313
-
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells: Interaction between the two biochemical barriers to intestinal transport
-
L. L. Gan, M. A. Moseley, B. Khosla, P. F. Augustijns, T. P. Bradshaw, R. W. Hendren, and D. R. Thakker. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells: Interaction between the two biochemical barriers to intestinal transport. Drug Met. Dis. 24:344-349 (1996).
-
(1996)
Drug Met. Dis.
, vol.24
, pp. 344-349
-
-
Gan, L.L.1
Moseley, M.A.2
Khosla, B.3
Augustijns, P.F.4
Bradshaw, T.P.5
Hendren, R.W.6
Thakker, D.R.7
-
25
-
-
0031022120
-
Application of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium
-
L. L. Gan and D. R. Thakker. Application of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium. Adv. Drug. Del. Rev. 23:77-98 (1997).
-
(1997)
Adv. Drug. Del. Rev.
, vol.23
, pp. 77-98
-
-
Gan, L.L.1
Thakker, D.R.2
-
26
-
-
0030581087
-
Active secretion and enterocytic drug metabolism barriers to drug absorption
-
V. J. Wacher, L. Salphati, and L. Z. Benet. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv. Drug Del. Rev. 20:99-112 (1996).
-
(1996)
Adv. Drug Del. Rev.
, vol.20
, pp. 99-112
-
-
Wacher, V.J.1
Salphati, L.2
Benet, L.Z.3
-
27
-
-
0030465760
-
Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4
-
C. L. Crespi, B. W. Penman, and M. Hu. Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Pharm. Res. 13:1635-1641 (1996).
-
(1996)
Pharm. Res.
, vol.13
, pp. 1635-1641
-
-
Crespi, C.L.1
Penman, B.W.2
Hu, M.3
-
28
-
-
0029855969
-
Comparison between permeability coefficients in rat and human jejunum
-
U. Fagerholm, M. Johansson, and H. Lennernäs. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1336-1342 (1996).
-
(1996)
Pharm. Res.
, vol.13
, pp. 1336-1342
-
-
Fagerholm, U.1
Johansson, M.2
Lennernäs, H.3
|