Competitive inhibition of glycylsarcosine transport by enalapril in rabbit renal brush border membrane vesicles: Interaction of ACE inhibitors with high-affinity H+/peptide symporter

Pharmaceutical Research

Volumn 16, Issue 5, 1999, Pages 609-615

  Lin, Chun Jung ^a   Akarawut, Wiyada ^a   Smith, David E ^a  

^a PFIZER INC   (United States)

Author keywords

ACE inhibitors; Competitive inhibition; Glycylsarcosine; Lipophilicity; Renal peptide transporter

Indexed keywords

ANTIPORTER; CAPTOPRIL; ENALAPRIL; ENALAPRILAT; FOSINOPRIL; GLYCYLSARCOSINE; LISINOPRIL; QUINAPRIL; QUINAPRILAT; RAMIPRIL; ZOFENOPRIL;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; DRUG PROTEIN BINDING; DRUG UPTAKE; KIDNEY TUBULE EPITHELIUM; LIPOPHILICITY; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BINDING, COMPETITIVE; CAPTOPRIL; CARRIER PROTEINS; CELL MEMBRANE; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENALAPRIL; FOSINOPRIL; ISOQUINOLINES; KIDNEY; KINETICS; LIPID METABOLISM; LIPIDS; LISINOPRIL; MALE; MICROVILLI; RABBITS; RAMIPRIL; SYMPORTERS; TETRAHYDROISOQUINOLINES;

EID: 0032912106     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018847818766     Document Type: Article

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