Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3925-3931

  Jensen, N P ^a   Ager, A L ^b   Bliss, R A ^a   Canfield, C J ^c   Kotecka, B M ^d   Rieckmann, K H ^d   Terpinski, J ^a   Jacobus, D P ^a  

^a Jacobus Pharmaceutical Co Inc   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c Pharmaceutical Systems Inc   (United States)

^d AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; BIGUANIDE DERIVATIVE; N [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] N' ISOPROPYLIMIDOCARBONIMIDIC DIAMIDE; PHENOXYPROPOXYBIGUANIDE DERIVATIVE; PRODRUG; PROGUANIL; PS 26; PS 33; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; MALE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHLOROGUANIDE; DRUG EVALUATION, PRECLINICAL; FEMALE; FOLIC ACID ANTAGONISTS; GUANIDINES; MALARIA; MALE; MICE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 0035829466     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010089z     Document Type: Article

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