Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7

Genetics

Volumn 162, Issue 1, 2002, Pages 285-296

  Baker, Scott E ^a,e   Lorenzen, James A ^c   Miller, Steven W ^a,f   Bunch, Thomas A ^a   Jannuzi, Alison L ^a   Ginsberg, Mark H ^d   Perkins, Lizabeth A ^c   Brower, Danny L ^a,b  

^a University of Arizona   (United States)

^b University of Arizona   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e SYNGENTA BIOTECHNOLOGY INC   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMPORTIN 7; INTEGRIN; INTEGRIN PS1; INTEGRIN PS2; KARYOPHERIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN; PROTEIN CORKSCREW; PROTEIN DIM 7; PROTEIN SUBUNIT; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; DROSOPHILA; FORELIMB; GENE; GENETIC SCREENING; LIGAND BINDING; MOLESKIN GENE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

ANIMALS; CELL NUCLEUS; DROSOPHILA; GENE EXPRESSION REGULATION; GENES, SUPPRESSOR; INTEGRINS; KARYOPHERINS; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

VERTEBRATA;

EID: 0036743344     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (79)

1. Allard, J. D., H. C. Chang, R. Herbst, H. McNeill and M. A. Simon, 1996 The SH2-containing tyrosine phosphatase Corkscrew is required during signaling by Sevenless, Rasl and Raf. Development 122: 1137-1146.
2. Allard, J. D., R. Herbst, P. M. Carroll, and M. A. Simon, 1998 Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew. J. Biol. Chem. 273: 13129-13135.
3. Aplin, A. E., S. A. Stewart, R. K. Assoian and R. L. Juliano, 2001 Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J. Cell Biol. 153: 273-282.
4. Assoian, R. K., and M. A. Schwartz 2001 Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 11: 48-53.
5. Baker, N. E., and G. M. Rubin, 1989 Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor. Nature 340: 150-153.
6. Bianchi, E., S. Denti, A. Granata, G. Bossi, J. Geginat et al., 2000 Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature 404: 617-621.
7. Bogaert, T., N. Brown and M. Wilcox, 1987 The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments. Cell 51: 929-940.
8. Brabant, M., C. D. Fristrom, T. A. Bunch and D. L. Brower, 1996 Distinct spatial and temporal functions for PS integrins during Drosophila wing morphogenesis. Development 122: 3307-3317.
9. Brabant, M. C., D. Fristrom, T. A. Bunch, S. E. Baker and D. L. Brower, 1998 The PS integrins are required for a regulatory event during Drosophila wing morphogenesis. Ann. NY Acad Sci. 857: 99-109.
10. Brand, A., A. Manoukian and N. Perrimon, 1994 Ectopic expression in Drosophila, pp. 635-654 in Drosophila melanogaster. Practical Uses in Cell and Molecular Biology, Methods in Cell Biology, Vol. 44, edited by L. GOLDSTEIN and E. FYRBERG. Academic Press, San Diego.
11. Brower, D. L., M. Wilcox, M. Piovant, R. J. Smith and L.A. Reger, 1984 Related cell-surface antigens expressed with positional specificity in Drosophila imaginal discs. Proc. Natl. Acad. Sci. USA 81: 7485-7489.
12. Brower, D. L., M. Piovant and L. A. Reger, 1985 Developmental analysis of Drosophila position-specific antigens. Dev. Biol. 108: 120-130.
13. PS1integrin subunit. Development 121: 1311-1320.
14. Brown, N. H., D. L. King, M. Wilcox and F. C. Kafatos, 1989 Developmentally regulated alternative splicing of Drosophila integrin PS2 α transcripts. Cell 59: 185-195.
15. Brown, N. H., S. T. Gregory and M. D. Martin-Bermudo, 2000 Integrins as mediators of morphogenesis in Drosophila. Dev. Biol. 223: 1-16.
16. Brunner, D., N. Oellers, J. Szabad, W. H. Biggs, III, S. L. Zipursky et al., 1994 A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76: 875-888.
17. Bunch, T. A., and D. L. Brower, 1992 Drosophila PS2 integrin mediates RGD dependent cell-matrix interactions. Development 116: 239-247.
18. Cleghon, V. P., S. T. Gregory, C. Ghiglione, T. D. Copeland, N. Perrimon et al., 1998 Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Mol. Cell 2: 719-727.
19. Condie, J. M., and D. L. Brower, 1989 Allelic interactions at the engrailed locus of Drosophila: engrailed protein expression in imaginal discs. Dev. Biol. 135: 31-42.
20. Dedhar, S., and G. E. Hannigan, 1996 Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr. Opin. Cell Biol. 8: 657-669.
21. Demali, K. A., E. Balciunaitf and A. Kazlauskas, 1999 Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF β receptor. J. Biol. Chem. 274: 19551-19558.
22. Diaz-Benjumea, F. J., and A. Garcia-Bellido, 1990 Behaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaics. Proc. R. Soc. Lond. Ser. B. Biol. Sci. 242: 36-44.
23. Diaz-Benjumea, F. J., and E. Hafen, 1994 The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. Development 120: 569-578.
24. Feng, G. S., 1999 Shp-2 tyrosine phosphatase: signaling one cell or many. Exp. Cell Res. 253: 47-54.
25. Fernandez, C., K. clark, L. Burrows, N. R. Schofield and M. J. Humphries, 1998 Regulation of the extracellular ligand binding activity of integrins. Front Biosci. 3: D684-D700.
26. Fristrom, D., M. Wilcox and J. Fristrom, 1993 The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development. Development 117: 509-523.
27. Giancotti, F. G., and E. Rouslahti, 1999 Integrin signaling. Science 285: 1028-1032.
28. Görlich, D., and U. Kutay, 1999 Transport between the cell nu-cleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15: 607-660.
29. Gotwals, P. J., S. E. Paine-Saunders, K. A. Stark and R. O. Hynes, 1994 Drosophila integrins and their ligands. Curr. Opin. Cell Biol. 6: 734-739.
30. Gricliatti, T., 1986 Mutagenesis, pp. 39-58 in Drosophila, A Practical Approach, edited by D. B. Roberts. IRL Press, Oxford.
31. Grotewiel, M. S., C. D. Beck, K. H. Wu, X. R. Zhu and R. L. Davis, 1998 Integrin-mediated short-term memory in Drosophila. Nature 391: 455-460.
32. Gruss, O. J., R. E. Carazo-Salas, C. A. Schatz, G. Guarguaglini, J. Kast et al., 2001 Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX2 activity. Cell 104: 83-93.
33. Guichard, A., B. Biehs, M. A. Sturtevant, L. Wickline, J. Chacko et al., 1999 Rhomboid and Star interact synergistically to promote EGFR/MAPK EGFR/NIAPK signaling during Drosophila wing vein development. Development 126: 2663-2676.
34. Herbst, R., P. M. Carroll, D. Allard, J. Schilling, T. raabe et al., 1996 Daughter ofsevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling. Cell 85: 899-909.
35. Hirsch, E., L. Barberis, M. Brancaccio, O. Azzolino, D. Xu et al., 2002 Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain. J. Cell Biol. 157: 481492.
36. Howe, A., A. E. Aplin, S. K. Alahari and R. L. Juiliano, 1998 Imegrin signaling and cell growth control. Curr. Opin. Cell Biol. 10: 220-231.
37. Hughes, P. E., and M. Pfaff, 1998 Integrin affinity modulation. Trends Cell Biol. 8: 359-364.
38. Hughes, P. E., M. W. Renshaw, M. pfaff, J. Forsyth, V. M. Keivens et al., 1997 Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88: 521-530.
39. Hynes, R. O., 1992 Integrins: versatility, modulation, and signalling in cell adhesion. Cell 69: 11-25.
40. Inagaki, K., T. Yamao, T. Noguchi, T. Matozaki, K. Fukunaga et al., 2000 SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J. 19: 6721-6731.
41. Irie, A., T. Kamata, W. Puzon-Mclaucghlin and Y. Takada, 1995 Critical amino acid residues for ligand binding are clustered in predicted β-turn of the third N-terminal repeat in the integrin α 4 and α 5 subunits. EMBO J. 14: 5550-5556.
42. Jackson, D. E., C. M. Ward, R. Wang and P. J. Newman, 1997 The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1 and integrin-mediated cellular signaling. J. Biol. Chem. 272: 6986-6993.
43. Jäkel, S., and D. Görlich, 1998 Importin β transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J. 17: 4491-4502.
44. Jäkel, S., W. Albic., U. Kutay, F. R. Bischoff, K. Schwamborn et al., 1999 The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBOJ. 18: 2411-2423.
45. Jannuzi, A. L., T. A. Bunch, M. C. Brabant, S. W. Miller, L. Mukai et al., 2002 Disruption of the C-terminal cytoplasmic domain of the βPS integrin subunit has dominant negative properties in developing Drosophila. Mol. Biol. Cell 13: 1352-1365.
46. Johnson Hamlet, M. R., and L. A. Perkins, 2001 Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis Genetics 159: 1073-1087.
47. Klämbt, C., 2000 EGF receptor signalling: the importance of presentation. Curr. Biol. 10: R388-R391.
48. Lacalle, R. A., E. Mira, C. Gómez-Moutón, S. Jiménez-Baranda, C. Martínez-A. et al., 2002 Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation. J. Cell Biol. 157: 277-289.
49. Lorenzen, J. A., S. E. Baker, F. Denhez, M. B. Melnick, D. L. Brower et al., 2001 Nuclear import of activated D-ERK by DIM-7, an Importin family member encoded by the gene moleskin. Development 128: 1403-1414.
50. Mackrell, A. J., B. Blumberg, S. R. Haynes and J. H. Fessler, 1988 The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin β subunits. Proc. Natl. Acad. Sci. USA 85: 2633-2637.
51. Manes, S., E. Mira, C. Gomez-Mouton, Z. J. Zhao, R. A. Lacalle et al., 1999 Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility. Mol. Cell. Biol. 19: 3125-3135.
52. Manseau, L., A. Baradaran, D. Brower, A. Budhu, F. Elefant et al., 1997 GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila. Dev. Dyn. 209: 310-322.
53. Martin-Bermundo, M. D., O. M. Dunin-Borkowski and N. H. Brown, 1998 Modulation of integrin activity is vital for morphogenesis. J. Cell Biol. 141: 1073-1081.
54. Martin-Blanco, E., F. Roch, E. Noll, A. Baonza, J. B. Duffy et al., 1999 A temporal switch in DER signaling controls the specification and differentiation of veins and interveins in the Drosophila wing. Development 126: 5739-5747.
55. Nachury, M. V., T. J. Maresca, W. C. Salmon, C. M. Watermanstorer, R. Heald et al., 2001 Importin β is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104: 96-106.
56. Newman, S. M., Jr., and T. R. F. Wright, 1981 A histological and ultrastructural analysis of developmental defects produced by the mutation, lethal(1)myospheroid, in Drosophila melanogaster. Dev. Biol. 86: 393-402.
57. Oh, E. S., H. Gu, T. M. Saxton, J. F. Timms, S. Hausdorff et al., 1999 Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol. Cell. Biol. 19: 3205-3215.
58. O'Toole, T. E., Y. Katagiri, R. J. Faull, K. Peter, R. Tamura et al., 1994 Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124: 1047-1059.
59. Perkins, L. A., I. Larsen and N. Perrimon, 1992 corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase Torso. Cell 70: 225-236.
60. Perkins, L. A., M. R. Johnson, M. B. Melnick and N. Perrimon 1996 The non-receptor protein tyrosine phosphatase Corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev. Biol. 180: 63-81.
61. Prout, M., Z. Damania, J. Soong, D. Fristrom and J. W. Fristrom, 1997 Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. Genetics 146: 275-285.
62. Sagawa, K., T. Kimura, M. Swieter and R. P. Siraganian, 1997 The protein-tyrosine phosphatase SHP-2 associates with tyrosinephosphorylated adhesion molecule PECAM-1 (CD31). J. Biol. Chem. 272: 31086-31091.
63. Schoenwaelder, S. M., L. A. Petch, D. Wiliamson, R. Shen, G. S. Feng et al., 2000 The protein tyrosine phosphatase Shp-2 regulates RhoA activity. Curr. Biol. 10: 1523-1526.
64. Stark, K. A., G. H. Yee, C. E. Roote, E. L. Williams, S. Zusman et al., 1997 A novel α integrin subunit associates with βPS and functions in tissue morphogenesis and movement during Drosophila development. Development 124: 4583-4594.
65. Struhl, G., and K. Basler, 1993 Organizing activity of the wingless protein in Drosophila. Cell 72: 527-540.
66. Sturtevant, M. A., and E. Bier, 1995 Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121: 785-801.
67. Tanoue, T., M. Adachi, T. Moriguchi and E. Nishida, 2000 A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell. Biol. 2: 110-116.
68. Tsuda, M., T. Matozaki, K. Fukunaga, Y. Fujioka, A. Imamoto et al., 1998 Integrin mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases. J. Biol. Chem. 273: 13223-13229.
69. Waddington, C. H., 1941 The genetic control of wing development in Drosophila. J. Genet. 41: 75-139.
70. Walsh E. P., and N. H. Brown, 1998 A screen to identify Drosophila genes required for integrin-mediated adhesion. Genetics 150: 791-805.
71. PSI a novel Drosophila melanogaster integrin. Mech. Dev. 43: 21-36.
72. Wiese, C., A. Wilde, M. S. Moore, S. A. Adam, A. Merdes et al., 2001 Role of importin-β in coupling Ran to downstream targets in microtubule assembly. Science 291: 653-656.
73. Wilcox, M. 1990 Genetic analysis of the Drosophila PS integrins. Cell Differ. Dev. 32: 391-400.
74. Wilcox, M., A. Diantonio and M. Leptin, 1989 The function of PS integrins in Drosophila wing morphogenesis. Development 107: 891-897.
75. Wright, T. R. F., 1960 The phenogenetics of the embryonic mutant, lethal myospheroid, in Drosophila melanogaster. J. Exp. Zool. 143: 77-99.
76. Xu, T., and G. M. Rubin, 1993 Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
77. Yamada, K. M., and S. Miyamoto, 1995 Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7: 681-689.
78. Yu, D. H., C. K. Qu, O. Henagariu, X. Lu and G. S. Feng, 1998 Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem. 273: 21125-21131.
79. Zavortink, M., T. A. Bunch and D. L. Brower, 1993 Functional properties of alternatively spliced forms of the Drosophila PS2 integrin α subunit. Cell Adhes. Commun. Commun. 1: 251-264.