Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain

Journal of Cell Biology

Volumn 157, Issue 3, 2002, Pages 481-492

  Hirsch, Emilio ^a,b   Barberis, Laura ^a   Brancaccio, Mara ^a   Azzolino, Ornella ^a   Xu, Dazhong ^e   Kyriakis, John M ^e   Silengo, Lorenzo ^a,b   Giancotti, Filippo G ^f   Tarone, Guido ^a,b   Fässler, Reinhard ^c,d   Altruda, Fiorella ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cytodomain; Integrin; MAPK; Proliferation; RAC

Indexed keywords

BETA1 INTEGRIN; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; RAC PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; GENE TARGETING; GROWTH REGULATION; HOMOZYGOTE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALLELES; ANIMALS; ANTIGENS, CD29; CELL ADHESION; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; FETAL DEATH; FIBROBLASTS; GENE TARGETING; HOMOZYGOTE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RAC GTP-BINDING PROTEINS;

ANIMALIA; MURINAE;

EID: 0037193467     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200111065     Document Type: Article

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