Genome instability and Rad50 S: Subtle yet severe

Genes and Development

Volumn 16, Issue 17, 2002, Pages 2173-2178

  De Jager, Martijn ^a   Kanaar, Roland ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

RAD50 PROTEIN; RAD51 PROTEIN; UNCLASSIFIED DRUG;

CELL CYCLE S PHASE; COMPLEX FORMATION; DNA REPAIR; DNA REPLICATION; GENE ISOLATION; GENETIC CONSERVATION; GENETIC STABILITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; TELOMERE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DNA REPAIR; DNA REPAIR ENZYMES; DNA REPLICATION; DNA-BINDING PROTEINS; GENOME; HUMANS; MACROMOLECULAR SUBSTANCES; MICE; MUTATION; PHENOTYPE; S PHASE;

EID: 0036712283     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1025402     Document Type: Review

References (60)

1. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
2. Structure of the Rad50 · Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy
3. Condensin and cohesin display different arm conformations with characteristic hinge angles
4. S/S mice
5. The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
6. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
7. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
8. Promotion of Dn14-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
9. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
10. The importance of repairing stalled replication forks
11. Recombination at double-strand breaks and DNA ends: Conserved mechanisms from phage to humans
12. The yeast Xrs2 complex functions in S phase checkpoint regulation
13. The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
14. Links between replication and recombination in Saccharomyces cerevisiae: A hypersensitive requirement for homologous recombination in the absence of Rad27 activity
15. Human Rad50/Mre11 is a flexible complex that can tether DNA ends
16. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
17. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
18. A 160-bp palindrome is a Rad50 · Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe
19. The tight linkage between DNA replication and double-strand break repair in bacteriophage T4
20. Mammalian telomeres end in a large duplex loop
21. The many interfaces of Mre11
22. Molecular architecture of SMC proteins and the yeast cohesin complex
23. The ABCs of SMC proteins: Two-armed ATPases for chromosome condensation, cohesion, and repair
24. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily
25. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
26. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
27. Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
28. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair
29. DNA double-strand breaks: Signaling, repair and the cancer connection
30. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
31. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
32. Tying up loose ends: Nonhomologous end-joining in Saccharomyces cerevisiae
33. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements
34. Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres
35. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
36. Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
37. Mre11 complex and DNA replication: Linkage to E2F and sites of DNA synthesis
38. Positional cloning of the gene for Nijmegen breakage syndrome
39. The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: Long, antiparallel coiled coils, folded at a flexible hinge
40. DNA repair: Spot(light)s on chromatin
41. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
42. Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae
43. Disseminating the genome: Joining, resolving, and separating sister chromatids during mitosis and meiosis
44. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
45. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
46. The Mre11 complex and ATM: Collaborating to navigate S phase
47. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast
48. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
49. Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break
50. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
51. DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50 · Mre11 complex
52. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
53. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
54. A murine model of Nijmegen breakage syndrome
55. Chromosome organization: Reaching out to embrace new models
56. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
57. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
58. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
59. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
60. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres