Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: Implications for disease regulation

Journal of Neuroimmunology

Volumn 130, Issue 1-2, 2002, Pages 10-21

  Columba Cabezas, Sandra ^a   Serafini, Barbara ^a   Ambrosini, Elena ^a   Sanchez, Massimo ^a   Penna, Giuseppe ^b   Adorini, Luciano ^b   Aloisi, Francesca ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b BioXell SpA   (Italy)

Author keywords

Brain; Chemokines; EAE; Glia; Th1 Th2

Indexed keywords

CHEMOKINE RECEPTOR CCR4; MACROPHAGE DERIVED CHEMOKINE; TRANSCRIPTION FACTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL INVASION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ANIMALS; ASTROCYTES; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CHEMOKINES, CC; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; MICE, INBRED STRAINS; MICROGLIA; MULTIPLE SCLEROSIS; RECEPTORS, CHEMOKINE; RNA, MESSENGER;

EID: 0036709217     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00170-4     Document Type: Article

References (70)

1. Aharoni R., Teitelbaum D., Leitner O., Meshorer A., Sela M., Arnon R. Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc. Natl. Acad. Sci. U. S. A. 9:2000;11472-11477.
2. Aloisi F. Immune function of microglia. Glia. 36:2001;165-179.
3. Aloisi F., Ria F., Penna G., Adorini L. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J. Immunol. 160:1998;4671-4680.
4. Aloisi F., Penna G., Polazzi E., Minghetti L., Adorini L. CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells. J. Immunol. 162:1999;1384-1391.
5. Aloisi F., Ria F., Adorini L. Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol. Today. 21:2000;141-147.
6. Aloisi F., Serafini B., Columba-Cabezas S., Adorini L. Dendritic cells in the central nervous system. Lotze M.T., Thomson A.W. Dendritic Cells. Biology and Clinical Applications. 2nd ed. 2001;371-387 Academic Press, New York.
7. Andrew D.P., Chang M.S., Mcninch J., Wathen S.T., Rihanek M., Spellberg J.P., Elias I.I.I. STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13. J. Immunol. 161:1998;5027-5038.
8. Andrew D.P., Ruffing N., Kim C.H., Miao W., Heath H., Li Y., Murphy K., Campbell J.J., Butcher E.C., Wu L. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. J. Immunol. 166:2001;103-111.
9. + T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. U. S. A. 96:1999;6873-6878.
10. Becher B., Durell B.G., Miga A.V., Hickey W.F., Noelle R.J. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J. Exp. Med. 193:2001;967-974.
11. Begolka W.S., Vanderlugt C.L., Rahbe S.M., Miller S.D. Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis. J. Immunol. 161:1998;4437-4446.
12. Bonecchi R., Bianchi G., Panina-Bordignon P., D'Ambrosio D., Lang R., Borsatti A., Sozzani S., Allavena P., Chantry D., Mantovani A., Sinigaglia F. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1) and Th2. J. Exp. Med. 187:1998;129-134.
13. Bonecchi R., Sozzani S., Stine J.T., Luini W., D'Amico G., Allavena P., Chantry D., Mantovani A. Divergent effects of interleukin-4 and interferon-γ on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses. Blood. 92:1998;2668-2671.
14. Campbell J.J., Haraldsen G., Pan J., Rottman J., Qin S., Ponath P., Andrew D.P., Warnke R., Ruffing N., Kassam N., Wu L., Butcher E.C. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature. 400:1999;776-780.
15. Campbell J.J., Pan J., Butcher E.C. Developmental switches in chemokine responses during T cell maturation. J. Immunol. 163:1999;2353-2357.
16. Chang M.S., Mcninch J., Elias C., Manthey C.L., Grosshans D., Meng T., Boone T., Andrew D.P. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. J. Biol. Chem. 272:1997;25229-25237.
17. Chantry D., Romagnani P., Raport C.J., Wood C.L., Epp A., Gray P.W. Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes. Blood. 94:1999;1890-1898.
18. Chvatchko Y., Hoogewerf A.J., Meyer A., Alouani S., Juillard P., Buser R., Conquet F., Proudfoot A.E.I., Wells T.N.C., Power C.A. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxin shock. J. Exp. Med. 191:2000;1755-1763.
19. D'Ambrosio D., Iellem A., Bonecchi R., Mazzeo D., Sozzani S., Mantovani A., Sinigaglia F. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 161:1998;5111-5115.
20. De Camargo Furtado G., Olivares-Villagomez D., Curotto De Lafaille M.A., Wensky A.K., Latowski J.A., Lafaille J.J. Regulatory T cells in spontaneous autoimmune encephalomyelitis. Immunol. Rev. 18:2001;122-134.
21. Di Rosa F., Serafini B., Scognamiglio P., Di Virgilio A., Finocchi L., Aloisi F., Barnaba V. Short-lived immunization site inflammation in self-limited active experimental allergic encephalomyelitis. Int. Immunol. 12:2000;71-719.
22. Fazekas G., Tabira T. What transgenic and knockout mouse models teach us about experimental autoimmune encephalomyelitis. Rev. Immunogenet. 2:2000;115-132.
23. Fife B.T., Huffnagle G.B., Kuziel W.A., Karpus W.J. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 192:2000;899-905.
24. Fischer F.R., Santambrogio L., Luo Y., Barman M.A., Hancock W.W., Dorf M.E. Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression. J. Neuroimmunol. 110:2000;195-208.
25. Flügel A., Bradl M., Kreutzberg G.W., Graeber M.B. Transformation of donor-derived bone marrow precursors into host microglia during autoimmune CNS inflammation and during the retrograde response to axotomy. J. Neurosci. Res. 66:2001;74-82.
26. Furlan R., Poliani P.L., Galbiati F., Bergami A., Grimaldi L.M., Comi G., Adorini L., Martino G. Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination. Hum. Gene Ther. 9:1998;2605-2617.
27. Gerritse K., Laman J.D., Noelle R.J., Aruffo A., Ledbetter J.A., Boersma W.J., Claassen E. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 93:1996;2499-2504.
28. Glabinski A.R., Ransohoff R.M. Chemokines and chemokine receptors in CNS pathology. J. Neurovirol. 5:1999;3-12.
29. Glabinski A., Tani M., Strieter R., Tuohy V., Ransohoff R.M. Synchronous synthesis of α- and β-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of experimental autoimmune encephalomyelitis. Am. J. Pathol. 150:1997;617-630.
30. Godiska R., Chantry D., Dietsch G.N., Gray P.W. Chemokine expression in murine experimental autoimmune encephalomyelitis. J. Neuroimmunol. 58:1995;167-176.
31. Godiska R., Chantry D., Raport C.J., Sozzani S., Allavena P., Leviten D., Mantovani A., Gray P.W. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J. Exp. Med. 185:1997;1595-1604.
32. Gonzalo J.-A., Pan Y., Lloyd C.M., Jia G.-Q., Yu G., Dussault B., Powers C.A., Proudfoot A.E.I., Coyle A.J., Gearing D., Gutierrez-Ramos J.-C. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. J. Immunol. 163:1999;403-411.
33. Harris R.G., Padilla J., Koumas L., Ray D., Phipps R.P. Prostaglandins as modulators of immunity. Trends Immunol. 23:2002;144-150.
34. Huang D.R., Wang J., Kivisäkk P., Rollins B.J., Ransohoff R.M. Absence of monocyte chemoattractant protein-1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193:2001;713-726.
35. + regulatory T cells. J. Exp. Med. 194:2001;847-853.
36. Imai T., Chantry D., Raport C.J., Wood C.L., Nishimura M., Godiska R., Yoshie O., Gray P.W. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273:1998;1764-1768.
37. Imai T., Nagira M., Takagi S., Kakizaki M., Nishimura M., Wang J., Gray P.W., Matsushima K., Yoshie O. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 11:1999;81-88.
38. Izikson L., Klein R.S., Charo I.F., Weiner H.L., Luster A.D. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J. Exp. Med. 192:2000;1075-1080.
39. Judge F., Alizadeh M., Boissier C., Chantry D., Siproudhis L., Corbina S., Quelvennec E., Dyard F., Campion J.P., Gosselin M., Bretagne J.F., Semana G., Heresbach D. Quantitation of chemokine (MDC, TARC) expression in mucosa from Crohn's disease and ulcerative colitis. Eur. Cytokine Netw. 12:2001;468-477.
40. Juedes A.E., Hjelmström P., Bergman C.M., Neild A.L., Ruddle N.H. Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J. Immunol. 164:2000;419-426.
41. Kennedy M.K., Torrance D.S., Picha K.S., Mohler K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:1992;2496-2505.
42. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1:1996;312-318.
43. 2 up-regulates macrophage-derived chemokine production but suppresses IFN-inducible protein-10 production by APC. J. Immunol. 166:2001;1650-1658.
44. Laman J.D., van Meurs M., Scellekens M.M., de Boer M., Melchers B., Massacesi L., Lassmann H., Claassen E., Hart B.A. Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus). J. Neuroimmunol. 86:1998;30-45.
45. Lutz M.B., Kukutsch N., Ogilvie A.L., Rossner S., Koch F., Romani N., Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods. 223:1999;77-92.
46. Mackay C.R. Chemokines: immunology's high impact factors. Nat. Immunol. 2:2001;95-101.
47. Mantovani A., Gray P.A., Van Damme J., Sozzani S. Macrophage-derived chemokine. J. Leukoc. Biol. 68:2000;400-404.
48. Matejuk A., Vandenbark A.A., Burrows G.G., Bebo B.F. Jr., Offner H. Reduced chemokine and chemokine receptor expression in spinal cords of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein. J. Immunol. 164:2000;3924-3931.
49. McCombe P.A., Nickson I., Pender M.P. Cytokine expression by inflammatory cells obtained from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis induced by inoculation with myelin basic protein and adjuvants. J. Neuroimmunol. 88:1998;30-38.
50. Olsson T. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:1995;245-268.
51. Owens T., Sriram S. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis. Neurol. Clin. 13:1995;51-73.
52. Panina-Bordignon P., Papi A., Mariani M., Di Lucia P., Casoni G., Bellettato C., Buonsanti C., Miotto D., Mapp C., Villa A., Arrigoni G., Fabbri L.M., Sinigaglia F. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J. Clin. Invest. 107:2001;1357-1364.
53. Pender M.P., Rist M.J. Apoptosis of inflammatory cells in immune control of the nervous system: role of glia. Glia. 36:2001;137-144.
54. Ransohoff R.M. Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines. J. Neuroimmunol. 98:1999;57-68.
55. Rottman J.B., Slavin A.J., Silva R., Weiner H.L., Gerard C.G., Hancock W.W. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur. J. Immunol. 30:2000;2372-2377.
56. Sallusto F., Lanzavecchia A., Mackay C.R. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol. Today. 19:1998;568-574.
57. Schaniel C., Pardali E., Sallusto F., Speletas M., Ruedl C., Seidl T., Anderson J., Melchers F., Rolink A.G., Sideras P. Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J. Exp. Med. 188:1998;451-463.
58. + T lymphocytes with regulatory activity. J. Immunol. 166:2001;996-1002.
59. Serafini B., Columba-Cabezas S., Di Rosa F., Aloisi F. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am. J. Pathol. 157:2000;991-2002.
60. + suppressor T cells. Immunol. Rev. 182:2001;58-67.
61. Simpson J., Newcombe J., Cuzner M., Woodroofe M.N. Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. J. Neuroimmunol. 84:1998;238-249.
62. Sørensen T.L., Tani M., Jensen J., Pierce V., Lucchinetti C., Folcik V.A., Qin S., Rottman J., Sellebjerg F., Strieter R.M., Frederiksen J.L., Ransohoff R.M. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J. Clin. Invest. 103:1999;807-815.
63. Steinman L. Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron. 24:1999;511-514.
64. Tang H.L., Cyster J.G. Chemokine up-regulation and activated T cell attraction by maturing dendritic cells. Science. 284:1999;819-822.
65. van Kooten C., Banchereau J. CD40-CD40 ligand. J. Leukoc. Biol. 67:2000;2-17.
66. Vecchi A., Massimiliano L., Ramponi S., Luini W., Bernasconi S., Bonecchi R., Allavena P., Parmentier M., Mantovani A., Sozzani S. Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells. J. Leukoc. Biol. 66:1999;489-494.
67. Vestergaard C., Yoneyama H., Murai M., Nakamura K., Tamaki K., Terashima Y., Imai T., Yoshie O., Irimura T., Mizutani H., Matsushima K. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J. Clin. Invest. 104:1999;1097-1105.
68. Vulcano M., Albanesi C., Stoppacciaro A., Bagnati R., D'Amico G., Struyf S., Transidico P., Bonecchi R., Del Prete A., Allavena P., Ruco L.P., Chiabrando C., Girolomoni G., Mantovani A., Sozzani S. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. Eur. J. Immunol. 31:2001;812-822.
69. Wingerchuk D.M., Lucchinetti C.F., Noseworthy J.H. Multiple sclerosis: current pathophysiological concepts. Lab. Invest. 81:2001;263-281.
70. Zlotnik A., Yoshie O. Chemokines a new classification system and their role in immunity. Immunity. 12:2000;121-127.