The regulation of actin remodeling during T-cell-APC conjugate formation

Immunological Reviews

Volumn 186, Issue , 2002, Pages 90-99

  Cannon, Judy L ^a   Burkhardt, Janis K ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL CYCLE PROTEIN; LEUKOCYTE ANTIGEN; LIGAND; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTEIN DERIVATIVE; RECEPTOR; T LYMPHOCYTE RECEPTOR; CELL ADHESION MOLECULE; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN; WAS PROTEIN, HUMAN; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN POLYMERIZATION; ANTIGEN PRESENTING CELL; CELL ADHESION; CELLULAR DISTRIBUTION; CONJUGATION; CYTOSKELETON; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; CHEMISTRY; CYTOLOGY; IMMUNOLOGY; METABOLISM;

ACTINS; ANIMALS; ANTIGEN-PRESENTING CELLS; CELL ADHESION MOLECULES; HUMANS; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 0036696565     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2002.18609.x     Document Type: Review

References (85)

1. Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS. T cell receptor signaling precedes immunological synapse formation. Science 2002;295:1539-1542.
2. Nieto M, Frade JM, Sancho D, Mellado M, Martinez AC, Sanchez-Madrid F. Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. J Exp Med 1997;186:153-158.
3. Negulescu PA, Krasieva TB, Khan A, Kerschbaum H, Cahalan M. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 1996;4:421-430.
4. Wei X, Tromberg BJ, Cahalan MD. Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca (2+) signaling. Proc Natl Acad Sci USA 1999;96:8471-8476.
5. Serrador JM, et al. CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood 1998;91:4632-4644.
6. Serrador JM, Nieto M, Sanchez-Madrid F. Cytoskeletal rearrangement during migration and activation of T lymphocytes. Trends Cell Biol 1999;9:228-233.
7. Brown MJ, Hallam JA, Liu Y, Yamada KM, Shaw S. Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. J Immunol 2001; 167:641-645.
8. Ratner S, Sherrod WS, Lichlyter D. Microtubule retraction into the uropod and its role in T cell polarization and motility. J Immunol 1997;159:1063-1067.
9. Podack ER, Kupfer A. T-cell effector functions: mechanisms for delivery of cytotoxicity and help. Annu Rev Cell Biol 1991;7:479-504.
10. Dustin ML, Bromley SK, Kan Z, Peterson DA, Unanue ER. Antigen receptor engagement delivers a stop signal to migrating T lymphocytes. Proc Natl Acad Sci USA 1997;94:3909-3913.
11. Yannelli JR, Sullivan JA, Mandell GL, Engelhard VH. Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography. J Immunol 1986;136:377-382.
12. Kupfer H, Monks C, Kupfer A. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopy studies of Th-B antigen-presenting cell interactions. J Exp Med 1994;179:1507-1515.
13. Burkhardt JK, McIlvain JM Jr, Sheetz MP, Argon Y. Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro. J Cell Sci 1993;104:151-162.
14. Acuto O, Cantrell D. T cell activation and the cytoskeleton. Annu Rev Immunol 2000;18:165-184.
15. Kupfer A, Burn P, Singer SJ. The PMA-induced specific association of LFA-1 and talin in intact cloned T helper cells. J Mol Cell Immunol 1990;4:317-325.
16. Kupfer A, Mosmann TR, Kupfer H. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. Proc Natl Acad Sci USA 1991;88:775-779.
17. Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;39S:82-86.
18. Grakoui A, et al. The immunological synapse: a molecular machine controlling T cell activation. Science 1999;285:221-227.
19. Lowin-Kropf B, Shapiro VS, Weiss A. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J Cell Biol 1998;140:861-871.
20. Sedwick CE, Morgan MM, Jusino L, Cannon JL, Miller J, Burkhardt JK. TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization. J Immunol 1999;162:1367-1375.
21. Cannon JL, et al. Wasp recruitment to the T cell. APC contact site occurs independendy of cdc42 activation. Immunity 2001;15:249-259.
22. Dustin ML, Cooper JA. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol 2000;1:23-29.
23. Liu S, Calderwood DA, Ginsberg MH. Integrin cytoplasmic domain-binding proteins. J Cell Sci 2000;113:3563-3571.
24. van Kooyk Y, Figdor CG. Avidity regulation of integrins: the driving force in leukocyte adhesion. Curr Opin Cell Biol 2000;12:542-547.
25. Lub M, van Kooyk Y, van Vliet SJ, Figdor CG. Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. Mol Biol Cell 1997;8:341-351.
26. 2+-dependent protease, calpain. J Cell Biol 1998;140:699-707.
27. Delon J, Kaibuchi K, Germain RN. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 2001;15:691-701.
28. Gunzer M, et al. Antigen presentation in extracellular matrix. Interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 2000;13:323-332.
29. Bromley SK, et al. The immunological synapse. Annu Rev Immunol 2001;19:375-396.
30. Kuhn JR, Poenie M. Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. Immunity 2002;16:111-121.
31. Morgan MM, Labno CM, Van Seventer GA, Denny MF, Straus DB, Burkhardt JK. Superantigen-induced T cell: B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J Immunol 2001;167:5708-5718.
32. Denny MF, Kaufman HC, Chan AC, Straus DB. The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling. J Biol Chem 1999;274:5146-5152.
33. Carey KD, et al. CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein rap1. Mol Cell Biol 2000;20:8409-8419.
34. Katagiri K, Hattori M, Minato N, Irie S, Takatsu K, Kinashi T. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol Cell Biol 2000;20:1956-1969.
35. Patel VP, Moran M, Low TA, Miceli MC. A molecular framework for two-step T cell signaling: Lck Src homology 3 mutations discriminate distinctly regulated lipid raft reorganization events. J Immunol 2001;166:754-764.
36. Villalba M, Bi K, Rodriguez F, Tanaka Y, Schoenberger S, Altman A. Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J Cell Biol 2001;155:331-338.
37. Valensin S, et al. F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts. Eur J Immunol 2002;32:435-446.
38. Griffiths EK, et al. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science 2001;293:2260-2263.
39. Wooten DK, Teague TK, McIntyre BW. Separation of integrin-dependent adhesion from morphological changes based on differential PLC specificities. J Leukoc Biol 1999;65:127-136.
40. Villalba M, Coudronniere N, Deckert M, Teixeiro E, Mas P, Altman A. A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. Immunity 2000;12:151-160.
41. Sun Z, et al. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 2000;404:402-407.
42. Henning S, Cleverley S. Small GTPases in lymphocyte biology: Rho proteins take center stage. Immunol Res 1999;20:29-42.
43. Johnson DI. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 1999;63:54-105.
44. Li R, Zheng Y, Drubin DG. Regulation of cortical actin cytoskeleton assembly during polarized cell growth in budding yeast. J Cell Biol 1995;128:599-615.
45. Nobes CD, Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 1999;144:1235-1244.
46. Allen WE, Zicha D, Ridley AJ, Jones GE. A role for Cdc42 in macrophage chemotaxis. J Cell Biol 1998;141:1147-1157.
47. Stowers L, Yelon D, Berg LJ, Chant J. Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. Proc Natl Acad Sci USA 1995;92:5027-5031.
48. Ridley AJ. Rho-related proteins: actin cytoskeleton and cell cycle. Curr Opin Genet Dev 1995;5:24-30.
49. Derry J, Ochs H, Francke U. Isolation of a novel gene mutated in Wiscott-Aldrich Syndrome. Cell 1994;78:635-644.
50. Aspenstrom P, Lindberg U, Hall A. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol 1996;6:70-75.
51. Kolluri R, et al. Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus. Hum Mol Genet 1995;4:1119-1126.
52. Symons M, et al. Wiscott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell 1996;84:723-734.
53. Ochs HD. The Wiskott-Aldrich syndrome. Semin Hematol 1998;35:332-345.
54. Zicha D, et al. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. Br J Haematol 1998;101:659-665.
55. Binks M, Jones GE, Brickell PM, Klnnon C, Katz DR, Thrasher AJ. Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome. Eur J Immunol 1998;28:3259-3267.
56. Kenney D, Cairns L, Remold-O'Donnell E, Peterson J, Rosen F, Parkman R. Morphological abnormalities in the lymphocytes of patients with the Wiscott-Aldrich syndrome. Blood 1986;68:1329-1332.
57. Molina I, Kenney D, Rosen F, Remold-O'Donnell E. T cell lines characterize events in the pathogenesis of the Wiscott-Aldrich syndrome. J Exp Med 1992;176:867-874.
58. Gallego MD, Santamaria M, Pena J, Molina IJ. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood 1997;90:3089-3097.
59. Facchetti F, et al. Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome. J Pathol 1998;185:99-107.
60. Snapper SB, et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 1998;9:81-91.
61. Zhang J, et al. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med 1999;190:1329-1342.
62. Abdul-Manan N, et al. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature 1999;399:379-383.
63. Rohatgi R, et al. The interaction between N-WASP and the Atp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 1999;97:221-231.
64. Machesky LM, et al. Scar, a WASp-related protein, activates nucleation of actin filaments by the Atp2/3 complex. Proc Natl Acad Sci USA 1999;96:3739-3744.
65. Mullins RD, Pollard TD. Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts. Curr Biol 1999;9:405-415.
66. Blanchoin L, Amann KJ, Higgs HN, Marchand JB, Kaiser DA, Pollard TD. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature 2000;404:1007-1011.
67. Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 2000;404:151-158.
68. Higgs HN, Pollard TD. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J Cell Biol 2000;150:1311-1320.
69. Prehoda KE, Scott JA, Dyche Mullins R, Lim WA. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science 2000;290:801-806.
70. Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J Cell Biol 2000;150:1299-1310.
71. Ramesh N, Anton IM, Hartwig JH, Geha RS. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci USA 1997;94:14671-14676.
72. Martinez-Quiles N, et al. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol 2001;3:484-491.
73. Anton IM, et al. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity 2002;16:193-204.
74. Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC. Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol Cell Biol 1995;15:5725-5731.
75. Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ. Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem 1996;271:25646-25656.
76. Moreau V, et al. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Nat Cell Biol 2000;2:441-448.
77. Krawczyk C, et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 2000;13:463-473.
78. Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol 2000;149:181-194.
79. Frischknecht F, Way M. Surfing pathogens and the lessons learned for actin polymerization. Trends Cell Biol 2001;11:30-38.
80. May RC, Machesky LM. Plagiarism and pathogenesis: common themes in actin remodeling. Dev Cell 2001;1:317-318.
81. Krawczyk C, et al. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 2002;16:331-343.
82. Bubeck-Wardenburg J, et al. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity 1998;9:607-616.
83. Holsinger LJ, et al. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol 1998;8:563-572.
84. Snapper SB, et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol 2001;3:897-904.
85. Zhang J, Shi F, Badour K, Deng Y, McGavin MK, Siminovitch KA. WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development. Proc Natl Acad Sci USA 2002;99:2240-2245.