Metabolic engineering of lactic acid bacteria for the production of nutraceuticals

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Volumn 82, Issue 1-4, 2002, Pages 217-235

  Hugenholtz, Jeroen ^a,b   Sybesma, Wilbert ^a   Nierop Groot, Masja ^a   Wisselink, Wouter ^a,c   Ladero, Victor ^d   Burgess, Kay ^e   Van Sinderen, Douwe ^e   Piard, Jean Christophe ^f   Eggink, Gerrit ^a,c   Smid, Eddy J ^b   Savoy, Graciela ^g   Sesma, Fernando ^g   Jansen, Tanja ^b   Hols, Pascal ^d   Kleerebezem, Michiel ^a,b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b NIZO FOOD RESEARCH   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^e UNIVERSITY COLLEGE CORK   (Ireland)

^f CEMAGREF   (France)

^g CENTRO DE REFERENCIA PARA LACTOBACILOS CERELA CONICET   (Argentina)

Author keywords

Folate; Galactose; Lactic acid bacteria; Lactococcus lactis; Low calorie sugars; Mannitol; Metabolic engineering; Nutraceuticals; Oligosaccharides; Riboflavin; Sorbitol; Tagatose

Indexed keywords

ALANINE; FOLIC ACID; LACTIC ACID; OLIGOSACCHARIDE; RIBOFLAVIN; SUGAR; VITAMIN B GROUP;

BACTERIUM; BIOTECHNOLOGY; LACTIC ACID;

ARTICLE; BACTERIAL GENETICS; BACTERIAL METABOLISM; BIOENGINEERING; BIOSYNTHESIS; BIOTECHNOLOGY; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; FOOD INDUSTRY; INTERNET; LACTIC ACID BACTERIUM; LACTOCOCCUS; NONHUMAN; PRIORITY JOURNAL;

FERMENTATION; GENETIC ENGINEERING; LACTOBACILLUS; POLYSACCHARIDES, BACTERIAL; SWEETENING AGENTS; VITAMINS;

BACTERIA (MICROORGANISMS); LACTOCOCCUS; LACTOCOCCUS LACTIS; POSIBACTERIA;

EID: 0036693744     PISSN: 00036072     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020608304886     Document Type: Article

References (92)

1. Spontaneous mutations changing the raffinose metabolism of Lactobacillus plantarum
2. Effect of fermentation on B-vitamin content of milk in Sweden
3. Micronutrient deficiencies cause DNA damage and cancer
4. Human riboflavin requirements and metabolic consequences of deficiency in man and animals
5. Xanthan gum biosynthesis and application: A biochemical/genetic perspective
6. Effects of exercise on riboflavin requirements of young women
7. Inhibition by selected food components of human and porcine intestinal pteroylpolyglutamate hydrolase activity
8. The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403
9. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease
10. Vitamins as homocysteine-lowering agents
11. Metabolic modeling of microbial strains in silico
12. High-throughput variation detection and genotyping using microarrays
13. Study of different forms of mannitol: Comparative behaviour under compression
14. Determination of full 13C isotopomer distributions for metabolic flux analysis using heteronuclear spin echo difference NMR spectroscopy
15. Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin
16. Heteropolysaccharides from lactic acid bacteria
17. Metabolic engineering of sugar catabolism in lactic acid bacteria
18. Low Calorie and Special Dietary Foods
19. Mannitol-enhanced survival of Lactococcus lactis subjected to drying
20. 13C nuclear magnetic resonance analysis of glucose and citrate end products in an ldhL-ldhD double-knockout strain of Lactobacillus plantarum
21. + ratio
22. Characterization of a-galactosidase from Lactobacillus fermentum
23. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics
24. Bifidogenic properties of different types of fructo-oligosaccharides
25. Polyhydric alcohols
26. Spontaneous formation of a mannitol-producing variant of Leuconostoc pseudomes-enteroides grown in the presence of fructose
27. Genetics of galactose utilisation via the Leloir pathway in lactic acid bacteria
28. Role of enzyme-bound 5, 10-methenyltetrahydropteroylpolyglut amate in catalysis by Escherichia coli DNA photolyase
29. Effects of riboflavin deficiency on the metabolism of the red blood cell
30. Alcohol and eye diseases: A review of epidemiologic studies
31. Metabolic engineering of lactic acid bacteria, the combined approach: Kinetic modelling, metabolic control and experimental analysis
32. Conversion of Lactococcus lactis from homolactic to homoalanine fermentation through metabolic engineering
33. Characterization of a water-soluble polysaccharide fraction with immunopotentiating activity from Bifidobacterium adolescentis M101-4
34. Accessing single nucleotide polymorhisms in genomic DNA by direct multiplex polymerase chain reaction amplification on nucleotide microarrays
35. Metabolic engineering of Lactococcus lactis leading to high diacetyl production
36. Dietary fiber and phophorylated oligosaccharide protect small intestinal mucosa of rat from oxidative damages in vitro
37. Hydrolysis of flatulence-causing galactooligosaccharides by agarose-entrapped Aspergillus oryzae cells
38. High production of D-tagatose, a potential sugar substitute, using immobilized L-arabinose isomerase
39. Antitumoral activity of slime-froming, encapsulated Lactococus lactis subsp. cremoris isolated from Scandinavian ropy sour milk, 'viili'
40. Metabolite and isotopomer balancing in the analysis of metabolic cycles: Theory
41. Exopolysaccharides produced by Lactococcus lactis: From genetic engineering to improved rheological properties?
42. Controlled gene expression systems for lactic acid bacteria: Transferable nisin inducible expression cassettes for Lactococcus, Leuconostoc and Lactobacillus spp
43. Lactic acid bacteria as a cell factory: Rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering
44. High-throughput SNP genotyping with the Masscode system
45. Quorum sensing-controlled gene expression in lactic acid bacteria
46. Riboflavin metabolism - Relevance to human nutrition
47. Physiological role of beta-phosphoglucomutase in Lactococus lactis
48. Requirement for phosphoglucomutase in exopolysaccharide biosynthesis in glucose- and lactose-utilizing Streptococcus thermophilus
49. Regulation of exopolysaccharide production by Lactococcus lactis subsp. cremoris by the sugar source
50. The role of NADH-oxidation in acetoin and diacetyl production from glucose in Lactococcus lactis
51. Cofactor engineering: A novel approach to metabolic engineering in Lactococcus lactis by controlled overexpression of NADH oxidase
52. Low-oligosaccharide soy milk: Application of a-galactosidase for hydrolysing soy-oligosaccharide
53. Biotransformations of D-galactitol to tagatose by acetic acid bacteria
54. Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells
55. Cholesterol lowering activity of ropy fermented milk
56. Structure of the extracellular polysaccharide from slime-forming Lactococcus lactis subspecies cremoris SBT0495
57. Low-cariogenicity of trehalose as a substrate
58. Metabolic characterization of Lactococcus lactis deficient in lactate dehydrogenase using in vivo 13C-NMR
59. Metabolite and isotopomer balancing in the analysis of metabolic cycles: Applications
60. Adaptation of the nisin-controlled expression system in Lactobacillus plantarum: A tool to study in vivo biological effects
61. The nutraceutical initiative: A proposal for economic and regulatory reform
62. Relationship between glycolysis and exopolysaccharides biosynthesis in Lactococcus lactis
63. 13C-NMR studies of Cyanobacterium melassecola metabolic pathways
64. Molecular cloning, characterization and nucleotide sequence of the tagatose-6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis
65. Inhibition of intestinal gamma-glutamyl carboxypeptidase by yeast nucleic acid: An explanation of variability in utilization of dietary polyglutamyl folate
66. Riboflavin deficiency in cultured rat hepatoma cells: A model for studying the hepatic effects of riboflavin deficiency
67. Quantitative analysis of metabolic fluxes in Escherichia coli, using two-dimensional NMR spectroscopy and complete isotopomer models
68. Properties of food folates determined by stability and susceptibility to intestinal pteroylpolyglutamate hydrolase action
69. Mannitol protects against oxidation by hydroxyl radicals
70. Structure, organization, and expression of the me1A structural gene for Α-galactosidase in Lactobacillus plantarum ATCC 8014
71. Increase of folate levels in fermented foods
72. Hydroxyl radical scavenging activity of compatible solutes
73. Production of D-mannitol and D-lactic acid by fermentation with Leuconostoc mesenteroides
74. Discovering the sweeping power of point mutations using a GIRAFF
75. Introduction of the exopolysaccharide gene cluster from Streptococcus thermophilus Sfi6 into Lactococcus lactis MG1363: Production and characterization of an altered polysaccharide
76. Novel and established applications of microbial polysaccharides
77. Improved efficiency and reliability of RT-PCR using tag-extended RT primers and temperature gradient PCR
78. Increased production of bioavailable folate by engineering of Lactococcus lactis
79. Molecular characterization of the plasmid-encoded eps gene cluster essential for exopolysaccharide biosynthesis in Lactococcus lactis
80. Exopolysaccharide biosynthesis in Lactococcus lactis NIZO B40: Functional analysis of the glycosyltransferase genes involved in synthesis of the polysaccharide backbone
81. Functional analysis of glycosyltransferase genes from Lactococcus lactis and other Gram-positive cocci: Complementation, expression, and diversity
82. Nucleotide sequence analysis of the lactococcal EPS plasmid pNZ4000
83. Involvement of a plasmid in production of ropiness (mucoidness) in milk cultures by Streptococcus cremoris MS
84. Substrate recognition at the cytoplasmic and extracellular binding site of the lactose transport protein of Streptococcus thermophilus
85. Construction of Streptococcus lactis subsp. lactis strains with a single plasmid associated with mucoid phenotype
86. Prevention of neural tube defects. Results of the Medical Research Council vitamin study
87. From microbial genome sequence to application
88. Microbial genome analysis: Insights into virulence, host adaptation and evolution
89. Human gamma glutamyl hydrolase: Cloning and characterization of the enzyme expressed in vitro
90. D-tagatose as a low-calorie carbohydrate sweetener and bulking agent