Mouse keratinocytes immortalized with large T antigen acquire α3β1 integrin-dependent secretion of MMP-9/gelatinase B

Journal of Cell Science

Volumn 113, Issue 16, 2000, Pages 2909-2921

  DiPersio, C M ^a   Shao, M ^a   Di Costanzo, L ^a   Kreidberg, J A ^a   Hynes, R O ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Extracellular matrix; Integrin; Keratinocyte; Matrix metalloproteinase

Indexed keywords

BETA1 INTEGRIN; GELATINASE B; GROWTH FACTOR; PROTEIN SUBUNIT; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME SYNTHESIS; GENETIC TRANSFECTION; KERATINOCYTE; MOUSE; NONHUMAN; NULL CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACTINS; ANIMAL; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL ADHESION MOLECULES; CELL DIVISION; CELL LINE, TRANSFORMED; CYTOSKELETON; EXTRACELLULAR MATRIX; GELATINASE B; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; INTEGRIN ALPHA3BETA1; INTEGRINS; KERATINOCYTES; MICE; SIGNAL TRANSDUCTION; SKIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033829605     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. Changes in keratinocyte-extracellular matrix interactions during terminal differentiation: Reduction in fibronectin binding precedes loss of α5β1 integrin from the cell surface
2. Expression of β1, β3, β4, and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes
3. Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1
4. Differentiation of human epidermal cells transformed by SV40
5. Transformation and tumor progression are frequently associated with expression of the α3β1 heterodimer in solid tumors
6. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that α3β1 complexes with EMMPRIN/basigin/OX47/M6
7. Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter
8. Structure and function of hemidesmosomes: More than simple adhesion structures
9. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
10. The dermal-epidermal junction
11. Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes
12. Integrins and signal transduction pathways: The road taken
13. The A and B variants of the α3 integrin subunit: Tissue distribution and functional characterization
14. Alterations in integrin receptor expression on chemically transformed human cells: Specific enhancement of laminin and collagen receptors
15. Distinct and overlapping ligand specificities of the α3Aβ1 and α6Aβ1 integrins: Recognition of laminin isoforms
16. α3Aβ1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins
17. α3β1 integrin is required for normal development of the epidermal basement membrane
18. The rabbit gene for 92-kDa matrix metalloproteinase: Role of AP1 and AP2 in cell type-specific transcription
19. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
20. Processing of laminin-5 and its functional consequences: Role of plasmin and tissue-type plasminogen activator
21. A cell signal pathway involving laminin-5, α3β1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation
22. Integrin associated proteins
23. Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line
24. Novel roles for α3β1 integrin as a regulator of cytoskeletal assembly and as a transdominant inhibitor of integrin receptor function in keratinocytes
25. Cooperative signalling by α5β1 and α4β1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
26. Integrins: Versatility, modulation, and signaling in cell adhesion
27. Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature
28. b-tsA58 transgenic mouse
29. Cancer invasion and tissue remodeling: Common themes in proteolytic matrix degradation
30. Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity
31. Matrix metalloproteinases in skin
32. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
33. Integrin receptors and RGD sequences in human keratinocyte migration: Unique anti-migratory function of α3β1 epiligrin receptor
34. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
35. Anti-integrin antibodies induce type IV collagenase expression in keratinocytes
36. Expression of integrins and basement membrane components by wound keratinocytes
37. Transforming growth factor-β regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes
38. Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive Simain Virus 40 large tumor antigen
39. Tumor suppressor genes: The p53 and retinoblastoma sensitivity genes and gene products
40. α1 and α2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression
41. T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40
42. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair
43. Antibodies to the conserved cytoplasmic domain of the integrin β1 subunit react with proteins in vertebrates, invertebrates, and fungi
44. The anchoring filament protein kalinin is synthesized and secreted as a high molecular weight precursor
45. The α3β1 integrin is involved in melanoma cell migration and invasion
46. Renal function is normal in gelatinase B deficient mice
47. Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen
48. Myogenic cell lines derived from transgenic mice carrying a thermolabile T antigen: A model system for the derivation of tissue-specific and mutation-specific cell lines
49. The alpha3beta1 integrin is associated with mammary carcinoma cell metastasis, invasion and gelatinase B (MMP-9) activity
50. Murine matrix metalloproteinase 9 gene: 5'-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice
51. Integrin expression in cutaneous malignant melanoma: Association of the alpha 3/beta 1 heterodimer with tumor progression
52. Expression of matrix metalloproteinases during rat skin wound healing: Evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A
53. Integrin laminin receptor profile of pulmonary squamous cell and adenocarcinomas
54. Matrix metalloproteinase 2 (MMP2) and MMP9 are produced by kidney collecting duct principal cells but are differentially regulated by SV40 large-T, arginine vasopressin, and epidermal growth factor
55. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
56. Changes in integrin receptors on oncogenically transformed cells
57. Elevated matrix metalloprotease and angiostatin levels in integrin α1 knock-out mice cause reduced tumor vascularization
58. Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization
59. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion
60. Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas
61. Integrin signaling to NF-κB in monocytic leukemia cells is blocked by activated oncogenes
62. Fibronectin and its integrin receptors in cancer
63. Cloning of the LamA3 gene encoding the α3 chain of the adhesive ligand epiligrin
64. Expression of matrix metalloproteinase-2 and -9 during early human wound healing
65. The role of integrins in tumorigenesis and metastasis
66. Integrins: Emerging paradigms of signal transduction
67. Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway
68. Matrix metalloproteinase degradation of the extracellular matrix: Biological consequences
69. Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2
70. Function of α3β1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2)
71. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid
72. Modulation of epidermal differentiation by epiligrin and integrin α3β1
73. Molecular cloning and expression of the cDNA for α3 subunit of human α3β1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen
74. Analysis of the avian fibronectin receptor (integrin) as direct substrate for pp60(v-src)
75. Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily
76. Keratinocyte integrins
77. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique α and common β subunits
78. ECM and cell surface proteolysis: Regulating cellular ecology
79. Regulation of matrix metalloproteinase expression in tumor invasion
80. Anchorage mediated by integrin α6β4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kDa protein
81. Conditional enhancement of liver-specific gene transcription