BMP signaling positively regulates Nodal expression during left right specification in the chick embryo

Development

Volumn 129, Issue 14, 2002, Pages 3431-3440

  Piedra, M Elisa ^a   Ros, Mana A ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

BMP; Car; CFC; Left right; Nodal; Pitx2

Indexed keywords

BONE MORPHOGENETIC PROTEIN; NOGGIN; PROTEIN NODAL; SONIC HEDGEHOG PROTEIN; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

CHICK EMBRYO; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SOMITE;

ANIMALS; AVIAN PROTEINS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; CHICK EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESODERM; PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SOMITES; TRANSFORMING GROWTH FACTOR BETA;

ERINACEIDAE; GASTROPODA; VERTEBRATA;

EID: 0036638638     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (83)

1. Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer that includes the transcription factor FAST2
2. BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos
3. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects
4. FGF8 functions in the specification of the right body side of the chick
5. Conserved and divergent mechanisms in left-right axis formation
6. The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping
7. Mechanisms of left-right determination in vertebrates
8. Smad 5 is essential for left-right asymmetry in mice
9. Improved method for chick whole-embryo culture using a filter paper carrier
10. The zebrafish Nodal signal Squint functions as a morphogen
11. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
12. Substractive hybridization identifies chick-cripto, a novel ECF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis
13. SPC4/PACE4 regulates a TGFbeta signaling network during axis formation
14. Tissue-specific requirements for the proprotein convertase Furin/SPC1 during embryonic turning and heart looping
15. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
16. Endogenous patterns of BMP signaling during early chick development
17. Limb initiation and development is normal in the absence of the mesonephros
18. A role of the cryptic in the correct establishment of the left-right axis
19. N-cadherin, a cell adhesion molecule involved in the establishment of embryonic left-right asymmetry
20. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
21. A series of normal stages in the development of the chick embryos
22. Links in the left-right axial pathway
23. The left-right coordinator: The role of Vg1 in organizing left-right axis formation
24. Control of vertebrate left-right asymmetry by a Snail-related zinc finger gene
25. Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates
26. The role of an endogenous PKA inhibitor, PKIa, in organizing left-right axis formation
27. Two novel T-box genes related to mouse Brachyury are expressed in different non overlapping mesodermal domains during gastrulation
28. Limits of pronephritic territory capable of autodifferentiating and providing primitive outline of the Wolffian duct in chick embryos
29. A molecular pathway determining left-right asymmetry in chick embryogenesis
30. Left-right patterning signals and the independent regulation of different aspects of situs in the chick embryo
31. Evolutionary conservation of mechanisms upstream of asymmetric Nodal expression reconciling chick and Xenopus
32. Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of Shh asymmetry in the node
33. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
34. Genetic dissection of nodal function in patterning the mouse embryo
35. Colocalization of BMP7 and BMP2 RNAs suggest that these factors cooperatively mediate tissue interactions during murine development
36. Left-right asymmetric expression of the TGF-beta-family member lefty in mouse embryos
37. Two closely-related left-right asymmetrically expressed genes, lefty1 and lefty2: Their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos
38. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
39. Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2
40. Left-right asymmetry determination in vertebrates
41. Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
42. Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling
43. Left-right asymmetry and Bmp4 signalling pathway during chick gastrulation
44. Bmp4 plays a key role in left-right patterning in chick embryos by maintaining Sonic Hedgehog asymmetry
45. A new technique for the cultivation of the chick embryo in vitro
46. Gizzard formation and the role of Bapx1
47. In situ hybridization analysis of chick embryos in whole mount and tissue sections
48. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
49. Asymmetric and node specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements
50. Abnormal nodal flow precedes situs inversus in in and inv mice
51. The transfer of left-right positional information during chick embryogenesis
52. Nodal signaling and the roles of the transcription factors SnR and Pitx2 in vertebrate left-right asymmetry
53. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry
54. BMPs negatively regulate structure and function of the limb apical ectodermal ridge
55. Cardiac looping and the vertebrate left-right axis: Antagonism of left-side Vg1 activity by a right-sided ALK-2 dependent BMP pathway
56. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry
57. Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo
58. Failure of ventral closure an axial rotation in embryos lacking the proprotein convertase Furin
59. Pitx2 determines left-right asymmetry of internal organs in vertebrates
60. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
61. Bmp2 is required for early heart development during a distinct time period
62. Chick CFC controls lefty1 expression in the embryonic midline and nodal expression in the lateral plate
63. BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo
64. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos
65. A role for bone morphogenetic proteins in the induction of cardiac myogenesis
66. Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo
67. Expression of fgf4 during early development of the chick embryo
68. The EGF-CFC gene family in vertebrate development
69. Two-steps regulation of left-right asymmetric expression of Pitx2: Initiation by Nodal signaling and maintenance by Nkx2
70. Roles of BMP signalling and Nkx 2.5 in patterning at the chick midgut-foregut boundary
71. Cloning and expression pattern of chicken Pitx2: A new component in the SHH signaling pathway controlling embryonic heart looping
72. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chisk embryo
73. -/- mice analysis
74. Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction
75. Nodal signaling in early vertebrate embryos: Themes and variations
76. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation
77. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
78. Antagonistic signalling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression
79. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry
80. Establishment of left-right asymmetry
81. Mesodermal patterning during avian gastrulation and neurulation: Experimental induction of notochord from non-notochordal precursors cells
82. Cerberus regulates left-right asymmetry of the embryonic head and heart
83. The Speman organizer signal noggin binds and inactivates bone morphogenetic protein 4