Genetic dissection of nodal function in patterning the mouse embryo

Development

Volumn 128, Issue 10, 2001, Pages 1831-1843

  Lowe, L A ^a   Yamada, S ^a   Kuehn, M R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Anteroposterior axis; Lateral plate mesoderm; Left right asymmetry; Mouse; Nodal; Node

Indexed keywords

PROTEIN NODAL; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ALLELE; ANALYSIS; ANGIOGENESIS; ANIMAL TISSUE; ANTERIOR POSTERIOR AXIS; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; GASTRULATION; GENE MUTATION; GENETICS; HEART DEVELOPMENT; HETEROZYGOSITY; LUNG DEVELOPMENT; MESODERM; MOLECULE; MOUSE; MUTANT; MUTATION; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STOMACH;

ALLELES; ANIMALS; BODY PATTERNING; FEMALE; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HETEROZYGOTE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PHENOTYPE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034981436     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. Endodermal Nodal-related signals and mesoderm induction in Xenopus
2. The organizer factors Chordin and Noggin are required for mouse forebrain development
3. Anterior patterning in mouse
4. Axis development and early asymmetry in mammals
5. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
6. Murine cerberus homologue mCer-1: A candidate anterior patterning molecule
7. Regulation of midline development by antagonism of lefty and nodal signaling
8. Vertebrate head induction by anterior primitive endoderm
9. A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs
10. Conserved and divergent mechanisms in left-right axis formation
11. Paraxis: A basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites
12. Quantitative RT-PCR assays show Xist RNA levels are low in mouse female adult tissue, embryos and embryoid bodies
13. The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping
14. The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
15. Mechanisms of left-right determination in vertebrates
16. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
17. The lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xenopus
18. Relationship between asymmetric nodal expression and the direction of embryonic turning
19. A novel retrovirally induced embryonic lethal mutation in the mouse: Assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration
20. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
21. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
22. Zebrafish organizer development and germ-layer formation require nodal-related signals
23. α1 adrenergic stimulation perturbs the left-right asymmetric expression pattern of nodal during rat embryogenesis
24. Dosage requirement of Pitx2 for development of multiple organs
25. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
26. Nodal signaling patterns the organizer
27. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
28. The function of silberblick in the positioning of the eye anlage in the zebrafish embryo
29. Rpx: A novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo
30. wis mutant embryos
31. Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis
32. The expression pattern of nodal and lefty in the mouse mutant Ft suggest a function in the establishment of handedness
33. Insertional mutation of a gene involved in growth regulation of the early mouse embryo
34. The SIL gene is required for mouse embryonic axial development and left- right specification
35. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
36. Xnr4: A Xenopus nodal-related gene expressed in the Spemann organizer
37. Nodal signaling uses activin and transforming growth factor-beta receptor-regulated smads
38. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
39. A molecular pathway determining left-right asymmetry in chick embryogenesis
40. Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo
41. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
42. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
43. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus
44. Whole mount in situ hybridization to study gene expression during mouse development
45. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development
46. A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation
47. Recent advances in gene mutagenesis by site-directed recombination
48. No turning, a mouse mutation causing left-right and axial patterning defects
49. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
50. Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression
51. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
52. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
53. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis
54. Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation
55. Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry
56. Cyclops encodes a nodal-related factor involved in midline signaling
57. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
58. Pitx2 determines left-right asymmetry of internal organs in vertebrates
59. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
60. Functional differences among Xenopus nodal-related genes in left-right axis determination
61. Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
62. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail
63. Nodal signalling in vertebrate development
64. Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis
65. Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
66. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
67. A nodal-related gene defines a physical and functional domain within the Spemann organizer
68. The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
69. One-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube
70. Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
71. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo
72. Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction
73. Hex: A homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
74. Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish
75. Formation of the definitive endoderm in mouse is a Smad2-dependent process
76. Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
77. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation
78. Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation