Cerberus regulates left-right asymmetry of the embryonic head and heart

Current Biology

Volumn 9, Issue 17, 1999, Pages 931-938

  Zhu, Lei ^a   Marvin, Martha J ^b   Gardiner, Aaron ^b   Lassar, Andrew B ^b   Mercola, Mark ^b   Stern, Claudio D ^a   Levin, Michael ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CERBERUS; CERCOPITHECUS; ERINACEIDAE; VERTEBRATA; XENOPUS; XENOPUS LAEVIS;

EID: 0033539140     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80419-9     Document Type: Article

References (45)

1. Waddington CH: The dependence of head curvature on the development of the heart in the chick embryo. J Exp Biol 1937, 14:229-231.
2. Harvey RP: Cardiac looping: An uneasy deal with laterality. Sem Cell Dev Biol 1998, 9:101-108.
3. Levin M, Mercola M: Evolutionary conservation of mechanisms upstream of asymmetric Nodal expression: Reconciling chick and Xenopus. Dev Genet 1998, 23:185-193.
4. Levin M, Mercola M: Gap junctions are involved in the early generation of left-right asymmetry. Dev Biol 1998, 203:90-105.
5. Levin M, Mercola M: The compulsion of chirality: Toward an understanding of left-right asymmetry. Genes Dev 1998, 12:763-769.
6. Ramsdell AF, Yost HJ: Molecular mechanisms of vertebrate left-right development. Trends Genet 1998, 14:459-465.
7. Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, et al.: Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 1998, 95:829-837.
8. King T, Brown NA: The left side gets all the best genes. Curr Biol 1999, 9:R18-R22.
9. Yost HJ: Left-right development from embryos to brains. Dev Genet 1998, 23:159-163.
10. Levin M: Left-right asymmetry in vertebrate embryogenesis. Bioessays 1997, 19:287-296.
11. Levin M, Johnson RL, Stern CD, Kuehn M, Tabin C: A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 1995, 82:803-814.
12. Levin M, Pagán S, Roberts DJ, Cooke J, Kuehn MR, Tabin CJ: Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo. Dev Biol 1997, 189:57-67.
13. Chen JN, van Eeden FJ, Warren KS, Chin A, Nüsslein-Volhard C, Haffter P, et al: Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 1997, 124:4373-4382.
14. Levin M: The roles of activin and follistatin signaling in chick gastrulation. Int J Dev Biol 1998, 42:553-559.
15. Boettger T, WittLer L, Kessel M: FGF8 functions in the specification of the right body side of the chick. Curr Biol 1999, 9:277-280.
16. Shimeld SM: The evolution of the hedgehog gene family in chordates: Insights from Amphioxus hedgehog. Dev Genes Evol 1999, 209:40-47.
17. Logan M, Pagán-Westphal SM, Smith DM, Paganessi L, Tabin CJ: The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell 1998, 94:307-317.
18. Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, et al.: Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 1998, 94:287-297.
19. Ryan AK, Blumberg B, Rodríguez-Esteban C, Yonei-Tamura S, Tamura K, Tsukui T, et al.: Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 1998, 394:545-551.
20. St. Amand TR, Ra J, Zhang Y, Hu Y, Baber SI, Qiu M, et al.: Cloning and expression pattern of chicken Pitx2: A new component in the SHH signaling pathway controlling embryonic heart looping. Biochem Biophys Res Commun 1998, 247:100-105.
21. Yoshioka H, Meno C, Koshiba K, Sugihara M, Itoh H, Ishimaru Y, et al.: Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 1998, 94:299-305.
22. Piedra ME, Icardo JM, Albajar M, Rodriguez-Rey JC, Ros MA: Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell 1998, 94:319-324.
23. Campione M, Steinbeisser H, Schweickert A, Deissler K, van Bebber F, Lowe LA, et al.: The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development 1999, 126:1225-1234.
24. Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM: Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 1996, 382:595-601.
25. Belo JA, Bouwmeester T, Leyns L, Kertesz N, Gallo M, Follettie M, et al.: Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev 1997 68:45-57.
26. Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, et al.: Murine cerberus homologue mCer-1: A candidate anterior patterning molecule. Dev Biol 1998, 194:135-151.
27. Knezevic V, Ranson M, Mackem S: The organizer-associated chick homeobox gene, Gnot1, is expressed before gastrulation and regulated synergistically by activin and retinoic acid. Dev Biol 1995, 171:458-470.
28. Hamburger V, Hamilton HL: A series of normal stages in the development of the chick embryo. J Morph 1951, 88:49-92.
29. Pagán-Westphal SM, Tabin CJ: The transfer of left-right positional information during chick embryogenesis. Cell 1998, 93:25-35.
30. Vasiliauskas D, Hancock S, Stern CD: SWiP-1 : Novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. Mech Dev 1999, 82:79-94.
31. Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM: The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1998, 1:673-683.
32. Osada SI, Wright CV: Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis. Development 1999, 126:3229-3240.
33. Piccolo S, Agius E, Leyns L, Bhattacharyya S, Grunz H, Bouwmeester T, et al.: The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 1999, 397:707-710.
34. Schultheiss TM, Burch JB, Lassar AB: A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 1997, 11:451-462.
35. Tonegawa A, Funayama N, Ueno N, Takahashi Y: Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4. Development 1997, 124:1975-1984.
36. Streit A, Stern CD: Establishment and maintenance of the border of the neural plate in the chick: Involvement of FGF and BMP activity. Mech Dev 1999, 82:51-66.
37. Pearce JJ, Penny G, Rossant J: A mouse cerberus/Dan-related gene family. Dev Biol 1999, 209:98-110.
38. Streit A, Stern CD: Mesoderm patterning and somite formation during node regression: Differential effects of chordin and noggin. Mech Dev 1999, 85:85-96.
39. Morgan BA, Fekete DM: Manipulating gene expression with replication-competent retroviruses. Methods Cell Biol 1996, 51:185-218.
40. Stern CD, Kakizuka A, Kintner CR, Mathews LS, Vale WW, Evans RM, et al.: Activin and its receptors during gastrulation and the early phases of mesoderm development in the chick embryo. Dev Biol 1995, 172:192-205.
41. Sundin O, Eichele G: An early marker of axial pattern in the chick embryo and its respecification by retinoic acid. Development 1992, 114:841-852.
42. Streit A, Lee KJ, Woo I, Roberts C, Jessell TM, Stern CD: Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development 1998, 125:507-519.
43. New DAT: A new technique for the cultivation of the chick embryo in vitro. J Embryol Exp Morph 1955, 3:326-331.
44. Stern CD, Ireland GW: An integrated experimental study of endoderm formation in avian embryos. Anat Embryol 1981, 163:245-263.
45. Stern CD: Avian embryos. In Essential Developmental Biology: A Practical Approach. Edited by Stern CD, Holland PWH. Oxford: IRL Press/Oxford University Press; 1993:67-78.