BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo

Development

Volumn 129, Issue 14, 2002, Pages 3421-3429

  Schlange, Thomas ^a   Arnold, Hans Henning ^a   Brand, Thomas ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

BMP; CFC; Chick; Left right asymmetry; NKX3.2; Nodal; Pitx2

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; GROWTH FACTOR; HOMEODOMAIN PROTEIN; NOGGIN; PROTEIN NODAL; RECEPTOR SUBTYPE; REGULATOR PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; EMBRYO DEVELOPMENT; GENE TARGETING; IMPLANTATION; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CELL ADHESION MOLECULES; CHICK EMBRYO; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; GALLUS GALLUS; VERTEBRATA;

EID: 0036638625     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos
2. FGF8 functions in the specification of the right body side of the chick
3. Conserved and divergent mechanisms in left-right axis formation
4. The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping
5. Mechanisms of left-right determination in vertebrates
6. Twisted gastrulation can function as a BMP antagonist
7. Smad5 is essential for left-right asymmetry determination and heart morphogenesis
8. The zebrafish Nodal signal Squint functions as a morphogen
9. Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo
10. N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry
11. Control of vertebrate left-right asymmetry by a snail-related zinc finger gene
12. Asymmetric expression of antivin/lefty1 in the early chick embryo
13. A molecular pathway determining left-right asymmetry in chick embryogenesis
14. Left/right patterning signals and the independent regulation of different aspects of situs in the chick embryo
15. Regulation of left-right asymmetry by thresholds of Pitx2c activity
16. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
17. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
18. Diffusion of Nodal signaling activity in the absence of the feedback inhibitor Lefty2
19. Left-right asymmetry determination in vertebrates
20. Membrane-anchorage of Cripto protein by glycosylphaspatidylinositol and its distribution during early mouse development
21. Left-right asymmetry in BMP4 signalling pathway during chick gastrulation
22. BMP4 plays a key role in left-right patterning in chick embryos by maintaining Sonic Hedgehog asymmetry
23. Gizzard formation and the role of Bapx1
24. The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling
25. The transfer of left-right positional information during chick embryogenesis
26. Nodal signalling and the roles of the transcription factors SnR and Pitx2 in vertebrate left-right asymmetry
27. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry
28. BMP signaling positively regulates Nodal expression during left-right specification in the chick embryo
29. Cardiac looping and the vertebrate left-right axis: Antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway
30. The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
31. Sonic hedgehog mediates the polarizing activity of the ZPA
32. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry
33. Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo
34. Twisted gastrulation is a conserved extracellular BMP antagonist
35. Pitx2 determines left-right asymmetry of internal organs in vertebrates
36. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
37. BMP2 is required for early heart development during a distinct time period
38. Chick cfc controls lefty1 expression in the embryonic midline and nodal expression in the lateral plate
39. Experimental induction of BMP-4 expression leads to apoptosis in the paraxial and lateral plate mesoderm
40. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos
41. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling
42. The EGF-CFC gene family in vertebrate development
43. Two-step regulation of left-right asymmetric expression of Pitx2: Initiation by nodal signaling and maintenance by Nkx2
44. Cloning and expression pattern of chicken Pitx2: A new component in the SHH signaling pathway controlling embryonic heart looping
45. Detection of multiple gene products simultaneously by in situ hybridization and immunohistochemistry in whole mounts of avian embryos
46. Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo
47. -/- mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Left-1
48. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation
49. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
50. BMP-2/-4 mediate programmed cell death in chicken limb buds
51. Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression
52. Cerberus regulates left-right asymmetry of the embryonic head and heart
53. Requirement for BMP signaling in interdigital apoptosis and scale formation