Establishment of left-right asymmetry

International Review of Cytology

Volumn 203, Issue , 2001, Pages 357-381

  Yost, H J ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

BMP; Brain; Heart; Intestine; Left right asymmetry; Lefty; Midline; Nodal; Pitx2; TGF ; Vg1

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CSNR; TRANSCRIPTION FACTOR NKX; TRANSCRIPTION REGULATOR PITX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

BRAIN ASYMMETRY; CELL ADHESION; CHICKEN; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; HEART DEVELOPMENT; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SNAIL; TRANSCRIPTION REGULATION;

GALLUS GALLUS; GASTROPODA; VERTEBRATA;

EID: 0035214358     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7696(01)03011-x     Document Type: Review

References (97)

1. Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer
2. Cell proliferation in mammalian gastrulation: The ventral node and notochord are relatively quiescent
3. Regulation of midline development by antagonism of lefty and nodal signaling
4. FGF8 functions in the specification of the right body side of the chick
5. The genetics of left-right development and heterotaxia
6. Regulation of gut and heart left-right asymmetry by context dependent interactions between Xenopus Lefty and BMP4 signaling
7. Cardiac design in lower vertebrates: What can phylogeny reveal about ontogeny?
8. The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping
9. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry
10. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
11. The lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xenopus
12. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
13. Relationship between asymmetric nodal expression and the direction of embryonic turning
14. Linkage of cardiac left-right asymmetry and dorsalanterior development in Xenopus
15. Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus
16. Habenular asymmetry and the central connections of the parietal eye of the lizard
17. Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms
18. Dosage requirement of Pitx2 for development of multiple organs
19. A role of the cryptic gene in the correct establishment of the left-right axis
20. Patterning the heart's left-right axis: From zebrafish to man
21. Asymmetry in the left and right habenulointerpeduncular tracts in the frog
22. Sex-dependent structural asymmetry of the medial habenular nucleus of the chicken brain
23. The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness
24. Initiation of vertebrate left-right axis formation by maternal vg1
25. The left-right coordinator: The role of Vg1 in organizing left-right axis formation
26. Control of vertebrate left-right asymmetry by a snail-related zinc finger gene
27. Asymmetric expression of antivin/leftyl in the early chick embryo
28. Actin bundles on the right side in the caudal part of the heart tube play a role in dextro-looping in the embryonic chick heart
29. The SIL gene is required for mouse embryonic axial development and left-right specification
30. The early phylogeny of chordates and echinoderms and the origin of chrodate left-right asymmetry and bilateral symmetry
31. The role of the brachyury gene in heart development and left-right specification in the mouse
32. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism
33. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development
34. Left-right asymmetry and the chick embryo
35. A molecular pathway determining left-right asymmetry in chick embryogenesis
36. Gap junctions are involved in the early generation of left-right asymmetry
37. Gap junction-mediated transfer of left-right patterning signals in the early chick blastoderm is upstream of shh asymmetry in the node
38. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
39. Maintenance of asymmetric nodal expression in Xenopus laevis
40. Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development
41. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus
42. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development
43. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
44. No turning, a mouse mutation causing left-right and axial patterning defects
45. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: Their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos
46. Left-right asymmetric expression of the TGFβ-family member lefty in mouse embryos
47. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
48. Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
49. Conservation of PDX-1 structure, function, and expression in zebrafish
50. Cloning of inv, a gene that controls left/right asymmetry and kidney development
51. Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse
52. The asymmetrical genetic determination of laterality: Flatfish, frogs and human handedness
53. Ranomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
54. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
55. Abnormal nodal flow precedes situs inversus in iv and inv mice
56. Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily
57. The transfer of left-right positional information during chick embryogenesis
58. Nodal signalling and the roles of the transcription factors SnR and Pitx2 in vertebrate left-right asymmetry
59. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry
60. Molecular mechanisms of vertebrate left-right development
61. Cardiac looping and the vertebrate left-right axis: Antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway
62. Cardiac looping and the left-right axis: Integrating morphological, molecular and genetic analyses of vertebrate left-right development
63. Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry
64. Cyclops encodes a nodal-related factor involved in midline signaling
65. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry
66. Pitx2 determines left-right asymmetry of internal organs in vertebrates
67. Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2
68. Functional differences among Xenopus nodal-related genes in left-right axis determination
69. Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
70. The homeobox gene it NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos
71. Pitx2 isoforms: Involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry
72. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
73. The evolution of the hedgehog gene family in chordates: Insights from amphioxus hedgehog
74. Cloning and expression pattern of chicken Pitx2: A new component in the SHH signaling pathway controlling embryonic heart looping
75. Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo
76. Morphogenesis of the murine node and notochordal plate
77. Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries
78. Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice
79. Left-right asymmetry and kinesin superfamily protein KIF3A: New insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis
80. Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo
81. Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction
82. Differential expression of flectin in the extracellular matrix and left-right asymmetry in mouse embryonic heart during looping stages
83. Left-right asymmetric localization of flectin in the extracellular matrix during heart looping
84. Multiple left-right asymmetry defects in Shh((-/-)) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1
85. Myocardialization of the cardiac outflow tract
86. A new spin on handed asymmetry
87. The roles of nodal cilia
88. Left-right asymmetry in animal development
89. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation
90. Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression
91. Reversal of left-right asymmetry: A situs inversus mutation
92. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry
93. Vertebrate left-right development
94. The genetics of midline and cardiac laterality defects
95. Left-right development from embryos to brains
96. Diverse initiation in a conserved left-right pathway?
97. Cerberus regulates left-right asymmetry of the embryonic head and heart