Effects of age on the posttranscriptional regulation of CCAAT/enhancer binding protein α and CCAAT/enhancer binding protein β isoform synthesis in control and LPS-treated livers

Molecular Biology of the Cell

Volumn 9, Issue 6, 1998, Pages 1479-1494

  Hsieh, Ching Chyuan ^a   Xiong, Wei ^a   Xie, Qizhi ^a   Rabek, Jeffrey P ^a   Scott, Sheen G ^a   An, Mi Ra ^a,b   Reisner, Peter D ^a   Kuninger, David T ^a   Papaconstantinou, John ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; ENHANCER REGION; HEPATITIS; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; STRESS; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0031816250     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.6.1479     Document Type: Article

References (49)

1. 1-acid-glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor. J. Biol. Chem. 268, 15681-15688.
2. 1-acid glycoprotein gene-1. Biochemistry 31, 1928-1936.
3. An, M.R., Hsieh, C-C., Reisner, P.D., Rabek, J.R., Scott, S.G., Kuninger, D.T., and Papaconstantinou, J. (1996). Evidence for post-transcriptional regulation of C/EBPα and C/EBPβ isoform expression during the lipopolysaccharide-mediated acute-phase response. Mol. Cell. Biol. 16, 2295-2306.
4. Baumann, H., Jahreis, G.P., and Morella, K.K. (1990). Interaction of cytokine- and glucocorticoid-response elements of acute-phase plasma protein genes. J. Biol. Chem. 265, 22275-22281.
5. Baumann, H., Morella, K.K., Campos, S.P., Cao, Z., and Jahreis, G.P. (1992). Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. J. Biol. Chem. 267, 19744-19751.
6. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
7. Brown, P.C., and Papaconstantinou, J. (1977). Identification of albumin synthesizing polysomes from mouse liver and a mouse hepatoma cell line. Biochem. Biophys. Res. Commun. 76, 121-128.
8. Calkhoven, C.F., Bouwman, P.R.J., Snippe, L., and Geert, A.B. (1994). Translation start site multiplicity of the CCAAT/enhancer binding protein a mRNA is dictated by a small 5′ open reading frame. Nucleic Acids Res. 22, 5540-5547.
9. Cao, Z., Umek, R.M., and McKnight, S.L. (1991). Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5, 1538-1552.
10. 1-acid glycoprotein genes (AGP-1 and AGP-2) during inflammation and aging. Biochim. Biophys. Acta 1089, 197-205.
11. Chang, C-J., Chen, T-T., Lei, H-Y., Chen, D-S., and Lee, S-C. (1990). Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol. Cell. Biol. 10, 6642-6653.
12. Choi, H-S., Lin, Z., Li, B., and Liu, A.Y-C. (1990). Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts. J. Biol. Chem. 265, 18005-18011.
13. Clarkson, R-W.E., Chen, C.M., Harrison, S., Wells, C., Muscat, A.E.O., and Waters, M.J. (1995). Early responses of trans-activating factors to growth hormone in preadipocytes; differential regulation of CCAAT enhancer-binding protein-P (C/EBPβ) and C/EBPδ. Mol. Endocrinol. 9, 108-120.
14. Descombes, P., Chojkier, M., Lichtsteiner, S., Falvey, E., and Schibler, U. (1990). LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4, 1541-1551.
15. Descombes, P., and Schibler, U. (1991). A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Genes Dev. 67, 569-579.
16. Fried, M.G., and Crothers, D.M. (1981). Equilibria and kinetics of LAC repressor operator interaction by polyacrylamide gel electrophoresis. Nucleic Acids Res. 9, 6505-6525.
17. Garner, M.M., and Revzin, A. (1981). A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions. Nucleic Acids Res. 9, 3047-3060.
18. Gluzman, Y. (1981). SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23, 175-182.
19. Heydari, A.R., Wu, B., Takahashi, R., Strong, R., and Richardson, A. (1993). Expression of heat shock protein 70 is altered by age and diet at the level of transcription. Mol. Cell. Biol. 13, 2909-2918.
20. Kozak, M. (1989). The scanning model for translation: an update. J. Cell Biol. 108, 229-241.
21. Kozak, M. (1992). A consideration of alternative models for the initiation of translation in eukaryotes. Crit. Rev. Biochem. Mol. Biol. 27, 385-402.
22. Kozak, M. (1995). Adherence to the first AUG rule when a second AUG codon follows closely upon the first. Proc. Natl. Acad. Sci. USA 92, 2662-2666.
23. Kunkel, T.A., Roberts, J.D., and Zakour, R.A. (1987). Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 254, 367.
24. Landschulz, W.H., Johnson, P.F., and McKnight, S.L. (1988). The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240, 1759-1764.
25. Landschulz, W.H., Johnson, P.F., and McKnight, S.L. (1989). The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science 243, 1681-1688.
26. Lin, F-T., and Lane, M.D. (1994). CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. USA 91, 8757-8761.
27. Lin, F-T., MacDougald, O.A., Diehl, A.M., and Lane, M.D. (1993). A 30 kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. Proc. Natl. Acad. Sci. USA 90, 9606-9610.
28. Liu, A.Y-C., Choi, H.S., Lu, Y-K., and Chen, K.Y. (1991). Molecular events involved in transcriptional activation of heat shock genes become progressively refractory to heat stimulation during aging of human diploid fibroblasts. J. Cell. Physiol. 149, 560-566.
29. Liu, A.Y-C., Lin, Z., Choi, H.S., Sorhage, F., and Li, B. (1989). Attenuated induction of heat shock gene expression in aging diploid fibroblasts. J. Biol. Chem. 264, 12037-12045.
30. Lopez-Cabrera, M., Letovsky, J., Hu, K., and Siddaqui, I. (1990). Multiple liver-specific factors bind to the hepatitis B virus core/ pregenomic promoter: trans-activation and repression by CCAAT/ enhancer binding protein. Proc. Natl. Acad. Sci. USA 87, 5069-5073.
31. Mahoney, C.W., Shuman, J., McKnight, S.L., Chen, H-C., and Huang, K-P. (1992). Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding. J. Biol. Chem. 267, 19396-19403.
32. Metz, R., and Ziff, E.B. (1991). cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription. Genes Dev. 5, 1754-1776.
33. Ossipow, V., Descombes, P., and Schibler, U. (1993). CCAAT/enhancer binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc. Natl. Acad. Sci. USA 90, 8219-8223.
34. Pei, D., and Shih, C. (1990). Transcriptional activation and repression by a cellular DNA binding protein C/EBP. J. Virol. 64, 1517-1522.
35. Pei, D., and Shih, C. (1991). An "attenuator domain" is sandwiched by two distinct transactivation domains in transcription factor C/EBP. Mol. Cell. Biol. 11, 1480-1487.
36. Post, D.J., Carter, K.C., and Papaconstantinou, J. (1991). The effect of aging on constitutive mRNA levels and LPS inducibility of acute phase genes. Ann. N.Y. Acad. Sci. 621, 66-77.
37. Rabek, J.P., Hoyt, P.R., Zhang, D-E., Izban, M.G., and Papaconstantinou, J. (1990). Derepression of a mouse α-fetoprotein expression factor in COS-1 cells by amplification of specific cis-acting sequences of the AFP promoter. Nucleic Acids Res. 18, 6677-6682.
38. Sears, R.C., and Sealy, L. (1994). Multiple forms of C/EBPβ bind the EFII enhancer sequence in the Rous Sarcoma Virus long terminal repeat. Mol. Cell. Biol. 14, 4855-4871.
39. Sierra, F., Fey, G.H., and Guigoz, Y.U. (1989). T-kininogen gene expression is induced during aging. Mol. Cell. Biol. 9, 5610-5616.
40. Supakar, P.C., Jung, M.H., Song, C.S., Chatterjee, B., and Roy, A.K. (1995). Nuclear factor κB functions as a negative regulator for the rat androgen receptor gene and NFκB activity increases during the age-dependent desensitization of the liver. J. Biol. Chem. 270, 837-842.
41. Timchenko, N.A., Harris, T.E., Wilde, M., Bilyeu, T.A., Burgess-Beusse, L., Finegold, M.J., and Darlington, G.J. (1997). CCAAT/ enhancer binding protein a regulates p21 protein and hepatocyte proliferation in newborn mice. Mol. Cell. Biol. 17, 7353-7361.
42. Timchenko, N.A., Wilde, M., Nakanisi, M., Smith, J.R., Darlington, G.J. (1996). CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10, 804-815.
43. Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M., and Chojkier, M. (1993). Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364, 544-547.
44. Umek, R.M., Friedman, A.D., and McKnight, S.L. (1991). CCAAT-enhancer binding protein: a component of a differentiation switch Science 251, 288-292.
45. Watt, F., and Malloy, L. (1993). Specific cleavage of transcription factors by the thiol protease, m-calpain. Nucleic Acids Res. 21, 5092-5100.
46. Wegner, M., Cao, Z., and Rosenfeld, M.G. (1992). Calcium-regulated phosphorylation with in the leucine zipper of C/EBP beta. Science 256, 370-373.
47. Williams, S.C., Baer, M., Dillner, A.J., and Johnson, P.F. (1995). CRP (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J. 14, 3170-3183.
48. Yin, M., Yang, S.Q., Lin, H.Z., Lane, M.D., Chatterjee, S., and Diehl, A.M. (1996). Tumor necrosis factor a promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes. J. Biol. Chem. 271, 17974-17978.
49. Zhang, D-E., Hoyt, P.R., and Papaconstantinou, J. (1990). Localization of DNA protein-binding sites in the proximal and distal promoter regions of the mouse α-fetoprotein gene. J. Biol. Chem. 265, 3382-3391.