The mRNA assembly line: Transcription and processing machines in the same factory

Current Opinion in Cell Biology

Volumn 14, Issue 3, 2002, Pages 336-342

  Bentley, David ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MESSENGER RNA PRECURSOR; RNA POLYMERASE II; CAPPED RNA; NUCLEAR PROTEIN;

DNA REPAIR; DNA TEMPLATE; MESSENGER RNA SYNTHESIS; NONHUMAN; POLYADENYLATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; REVIEW; RNA BINDING; RNA CAPPING; RNA CLEAVAGE; RNA PROCESSING; RNA SPLICING; RNA TRANSCRIPTION; SPLICEOSOME; TRANSCRIPTION INITIATION; TRANSCRIPTION TERMINATION; 3' UNTRANSLATED REGION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; GENETIC TRANSCRIPTION; METABOLISM; PROMOTER REGION;

3' UNTRANSLATED REGIONS; ANIMALS; MODELS, GENETIC; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA CAPS; RNA POLYMERASE II; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; RNA, MESSENGER; SPLICEOSOMES; TRANSCRIPTION, GENETIC;

EID: 0036591882     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(02)00333-2     Document Type: Review

References (68)

1. Assembly and transport of a premessenger RNP particle
2. Dynamic association of capping enzymes with transcribing RNA polymerase II
3. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription
4. The intranuclear site of excision of each intron in Balbiani ring 3 pre-mRNA is influenced by the time remaining to transcription termination and different excision efficiencies for the various introns
5. Functional interaction of yeast pre-mRNA 3′-end processing factors with RNA polymerase II
6. Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation
7. Messenger RNAs are recruited for nuclear export during transcription
8. RNA editing by base deamination: More enzymes, more targets
9. Precursor RNAs harboring nonsense codons accumulate near the site of transcription
10. Coupled transcription and translation within nuclei of mammalian cells
11. The BARD1-CstF-50 interaction links mRNA 3′ end formation to DNA damage and tumor suppression
12. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution
13. 5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
14. The C-terminal domain of RNA polymerase II couples messenger RNA processing to transcription
15. RNA polymerase II is an essential mRNA polyadenylation factor
16. The CTD of RNA polymerase II interacts with a novel set of SR-like proteins
17. Functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-messenger RNA splicing
18. Capping, splicing and 3′ processing are independently stimulated by RNA polymerase II: Different functions for different segments of the CTD
19. Pre-messenger-RNA processing and the CTD of RNA polymerase II - The tail that wags the dog
20. Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser2 of the RNA polymerase II C-terminal domain
21. Origins of mRNA identity: Capping enzymes bind to the phosphorylated C-terminal domain of RNA polymerase II
22. MRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain
23. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA pol II
24. Distinct effector roles for Ser2 and Ser5 phosphorylation of the RNA polymerase II CTD in the recruitment and allosteric activation of mammalian capping enzyme
25. Transcription elongation factor hSPT5 stimulates mRNA capping
26. HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA
27. In situ transcription and splicing in the Balbiani ring 3 gene
28. Uncoupling yeast intron recognition from transcription with recursive splicing
29. Stimulatory effect of splicing factors on transcriptional elongation
30. A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly
31. Analysis of CTD and phospho-CTD binding by yeast WW domain-containing proteins reveals that the splicing factor, Prp40, is a phospho-CTD binding protein
32. Participation of the C-terminal domain of RNA polymerase II in exon definition during pre-mRNA splicing
33. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing
34. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo
35. A functional interaction between the survival motor neuron complex and RNA polymerase II
36. Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer
37. A human papillomavirus E2 transcriptional activator. The interactions with cellular splicing factors and potential function in pre-mRNA processing
38. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
39. The acute myeloid leukaemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
40. The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS
41. Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma
42. EWS-Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing
43. TLS-ERG leukaemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins
44. Coupled in vitro synthesis and splicing of RNA polymerase II transcripts
45. Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing
46. EM visualization of transcription by RNA polymerase II: Downstream termination requires a poly(A) signal but not transcript cleavage
47. Mechanism of poly(A) signal transduction to RNA polymerase II in vitro
48. Transcriptional termination and coupled polyadenylation in vitro
49. Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II
50. Coupling termination of transcription to messenger RNA maturation in yeast
51. Mutations in a peptidylprolyl-cis/trans-isomerase gene lead to a defect in 3′-end formation of a pre-mRNA in Saccharomyces cerevisiae
52. Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II
53. Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomyces cerevisiae
54. Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in premRNA 3′-end formation
55. RNA-binding protein Nrd1 directs poly(A)-independent 3′-end formation of RNA polymerase II transcripts
56. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination
57. Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation
58. Transcriptional termination factors for RNA polymerase II in yeast
59. Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes
60. Transcription factor TFIID recruits factor CPSF for formation of 3′ end of mRNA
61. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation
62. WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes
63. A new view of mRNA export: Separating the wheat from the chaff
64. The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery
65. A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2
66. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors
67. Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3′cleavage
68. Integrating mRNA processing with transcription