A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicing

Journal of Cell Biology

Volumn 136, Issue 1, 1997, Pages 5-18

  Du, Lei ^a,b   Warren, Stephen L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GENOME THERAPEUTICS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BETA GLOBIN; HEPTAPEPTIDE; HYBRID PROTEIN; MESSENGER RNA PRECURSOR; RECOMBINANT PROTEIN; RNA POLYMERASE II; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA SPLICING;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; FIBROBLASTS; GLOBINS; HAPLORHINI; HELA CELLS; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA POLYMERASE II; RNA PRECURSORS; RNA SPLICING;

EID: 0031032049     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.136.1.5     Document Type: Article

References (38)

1. Andrade, L.E., E.M. Tan, and E.K.L. Chan. 1993. Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation. Proc. Natl. Acad. Sci. USA. 90:1947-1951.
2. Ascoli, C.A., and G.G. Maul. 1991. Identification of a novel nuclear domain. J. Cell Biol. 112:785-795.
3. Barén, G., and L. Wieslander. 1994. Splicing of Balbiani Ring 1 gene pre-mRNA occurs simultaneously with transcription. Cell. 76:183-192.
4. Beyer, A.L., and Y.N. Osheim. 1988. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev. 2:754-765.
5. Beyer, A.L., and Y.M. Osheim. 1991. Visualization of RNA transcription and processing. Semin. Cell Biol. 2:131-140.
6. Blencowe, B.J., J.A. Nickerson, R. Issner, S. Penman, and P.A. Sharp. 1994. Association of nuclear matrix antigens with exon-containing splicing complexes. J. Cell Biol. 127:593-607.
7. Blencowe, B.J., R. Issner, J. Kim, P. McCaw, and P.A. Sharp. 1995. New proteins related to the SerArg family of splicing factors. RNA. 1:852-865.
8. Blencowe, B.J., M.J. Mortillaro, X. Wei, H. Nakayasu, L. Du, S.L. Warren, P.A. Sharp, and R. Berezney. 1996. A hyperphosphorylated form of the largest subunit of RNA polymerase II is associated with splicing complexes. Proc. Natl. Acad. Sci. USA. 93:8253-8257.
9. Bregman, D.B., L. Du, S. Ribisi, and S.L. Warren. 1994. Cytostellin distributes to nuclear regions enriched with splicing factors. J. Cell Sci. 10:387-396.
10. Bregman, D.B., L. Du, S. van der Zee, and S.L. Warren. 1995. Transcription- dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains. J. Cell Biol. 129:287-298.
11. Caceres, J.F., S. Stamm, D.M. Helfman, and A.R. Krainer. 1994. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (Wash. DC). 265:1706-1709.
12. Dahmus, M.E. 1996. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271:19009-19012.
13. Fu, X-D. 1995. The superfamily of arginine/serine-rich spliling factors. RNA. 1: 663-680.
14. Gall, J.G. 1991. Spliceosomes and snurposomes. Science. (Wash. DC). 252: 1499-1500.
15. Gerber, H.P., M. Hagmann, K. Seipel, O. Georgiev, L.A. West, Y. Litingtung, W. Schaffner, and J.L. Corden. 1995. RNA polymerase II C-termmal domain required for enhancer-driven transcription. Nature (Lond.). 374:660-662.
16. Greenleaf, A.L. 1993. Positive patches and negative noodles: linking RNA processing to transcription? Trends Biochem. Sci. 18:117-119.
17. Kim, E., L. Du, D. Bregman, and S. Warren. 1997. Splicing factors associate with hyperphosphorylatod RNA polymerase II in the absence of premRNA. J. Cell Biol. In press.
18. Koleske, A.J., and R.A. Young. 1995. The RNA polymerase II holoenzyme and its implications for gene regulation. Trends Biochem. Sci. 20:113-116.
19. Lamond, A.I., and M. Carmo-Fonseca. 1993. The coiled body. Trends Cell Biol. 3-198-204
20. Lerner, E.A., M.R. Lerner, C. Janeway, and J.A. Steitz. 1981. Monoclonal antibodies to nucleic acid containing cellular constituents: probes for molecular biology and autoimmune disease. Proc. Natl. Acad. Sci. USA. 78:2737-2741.
21. a) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing. Cell. 67:335-342.
22. Matunis, E., M.J. Matunis, and G. Dreyfuss. 1993. Association of individual hnRNP proteins and snRNPs with nascent transcripts. J. Cell Biol. 121:219-228.
23. Maul, G.G., and R.D. Everett. 1994. The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0. J. Gen. Virol. 75:1223-1233.
24. Nonet, M., D. Sweetser, and R.A. Young. 1987. Functional redundancy and structural polymorphism in the large subunit of RNA polymerase II. Cell. 50:909-915.
25. Romac, J.M., and J.D. Keene. 1995. Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. Genes Dev. 9:1400-1410.
26. Roth, M.B., A.M. Zahler, and J.A. Stolk. 1991. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J. Cell Biol. 115:587-596.
27. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Labo- ratory Manual. 2nd Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
28. Scafe, C., D. Chao, J. Lopes, J.P. Hirsch, S. Henry, and R.A. Young. 1990. RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals. Nature (Lond.). 347:491-494.
29. Sharp, P.A. 1994. Split genes and RNA splicing. Cell. 77:805-815.
30. Terris, B., V. Baldin, S. Dubois, C. Degott, J.-F., Flejou, and D. Henin. 1995. PML nuclear bodies are general targets for inflammation and cell proliferation. Cancer Res. 55:1590-1597.
31. Warren, S.L., A.S. Landolfi, C. Curtis, and J.S. Morrow. 1992. Cytostellin: a novel, highly conserved protein that undergoes continuous redistribution during the cell cycle. J. Cell Sci. 103:381-388.
32. Wintzerith, M., J. Acker, S. Vicaire, M. Vigneron, and C. Kedinger. 1992. Complete sequence of the human RNA polymerase II largest subunit. Nucleic Acids Res. 20:910.
33. Xing, Y., C.V. Johnson, P.R. Dobner, and J.B. Lawrence. 1993. Higher level organization of individual gene transcription and RNA splicing. Science (Wash. DC). 259:1326-1330.
34. Xing, Y., C.V. Johnson, P.T. Moen, J.A. McNeil, and J.B. Lawrence. 1995. Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains. J. Cell Biol. 131:1635-1647.
35. Yuryev, A., M. Patturajan, Y. Litingtung, R.V. Joshi, C. Gentile, M. Gebara, and J.L. Corden. 1996. The CTD of RNA polymerase II interacts with a novel set of SR-like proteins. Proc. Natl. Acad. Sci. USA. 93:6975-6980.
36. Zeng, C., E. Kim, S.L. Warren, and S.M. Berget. 1997. Dynamic relocalization of transcription and splicing factors dependent on transcriptional activity EMBO (Eur. Mol. Biol. Organ.) J. In press.
37. Zehring, W.A., J.M. Lee, J.R. Weeks, R.S. Jokerst, and A.L. Greenleaf. 1988. The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro. Proc. Natl. Acad. Sci. USA. 85:3698-3702.
38. Zhang, G., K.L. Taneja, R.H. Singer, and M.R. Green. 1994. Localization of pre-mRNA splicing in mammalian nuclei. Nature (Lond.). 372:809-812.