RNA editing by base deamination: More enzymes, more targets, new mysteries

Trends in Biochemical Sciences

Volumn 26, Issue 6, 2001, Pages 376-384

  Gerber, André P ^a   Keller, Walter ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; CYTIDINE; ENZYME; MESSENGER RNA PRECURSOR; RNA; TRANSFER RNA;

CATALYSIS; CATALYST; DEAMINATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN TARGETING; REVIEW; RNA EDITING;

ADENOSINE DEAMINASE; AMINO ACID SEQUENCE; BASE SEQUENCE; CYTIDINE DEAMINASE; DEAMINATION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEOTIDES; RNA; RNA EDITING; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0035369742     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01827-8     Document Type: Review

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6. Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2
7. An adenosine deaminase that generates inosine at the wobble position of tRNAs
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9. Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3′ efficiency element
10. Evolutionary origins of apoB mRNA editing: Catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site
11. Echerichia coli cytidine deaminase provides a molecular model for apoB RNA editing and a mechanism for RNA substrate recognition
12. Molecular cloning of apobec-1 complementation factor, a novel RNA- binding protein involved in the editing of apolipoprotein B mRNA
13. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex
14. Identification of GRY-RBP as an apolipoprotein B RNA binding protein that interacts with both apobec-1 and with apobec-1 complementation factor (ACF) to modulate C to U editing
15. Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing
16. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1
17. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family
18. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
19. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
20. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
21. RNA editing by base conversion in plant organellar RNAs
22. RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs
23. C to U editing of the anticodon of imported mitochondrial tRNA(Trp) allows decoding of the UGA stop codon in Leishmania tarentolae
24. Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA
25. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains
26. Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes
27. dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing
28. Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible
29. Human RNA-specific adenosine deaminase (ADAR1) gene specifies transcripts that initiate from a constitutively active alternative promoter
30. A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase
31. Crystal structure of the Zα domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA
32. Expression and regulation by interferon of a doubled-stranded-RNA-specific adenosine deaminase from human cells: Evidence for two forms of the deaminase
33. Analysis of Xenopus dsRNA adenosine deaminase cDNAs reveals similarities to DNA methyltransferases
34. + channels with altered functional properties
35. + RNA
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39. + channel transcript in a region of RNA editing
40. A Drosophila calcium channel α1 subunit gene maps to a genetic locus associated with behavioral and visual defects
41. Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications
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43. Regulation of alternative splicing by RNA editing
44. Early-onset epilepsy and postnatal lethality associated with editing-deficient GluR-B allele in mice
45. A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
46. Enzymatic formation of inosine in pre-mRNA and tRNA by adenosine deamination
47. The importance of internal loops within RNA substrates of ADAR1
48. In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site
49. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
50. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis
51. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
52. Mechanism, specificity and general properties of the yeast enzyme catalysing the formation of inosine 34 in the anticodon of transfer RNA
53. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes
54. Sequence, genomic organization and functional expression of the murine tRNA-specific adenosine deaminase ADAT1
55. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification
56. Involvement of a site-specific trans-acting factor and a common RNA-binding protein in the editing of chloroplast mRNAs: Development of a chloroplast in vitro RNA editing system
57. The RNA world meets behavior: A→I pre-mRNA editing in animals