Vascular protective actions of a nitric oxide aspirin analog in both in vitro and in vivo models of diabetes mellitus

Free Radical Biology and Medicine

Volumn 32, Issue 11, 2002, Pages 1143-1156

  Pieper, Galen M ^a   Siebeneich, Wolfgang ^a,b   Olds, Cara L ^a,b   Felix, Christopher C ^a   Soldato, Piero Del ^c  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b FREE RADICAL RESEARCH CENTER   (United States)

^c NicOx SA   (France)

Author keywords

Aspirin; Diabetes mellitus; Electron spin resonance spectroscopy; Endothelium; Free radicals; Hydroxyl radical; Hyperglycemia; Lipid peroxides; Nitric oxide; Nuclear factor B; Superoxide

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ACETYLCHOLINE; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ACETYLSALICYLIC ACID DERIVATIVE; ANTIOXIDANT; FLURBIPROFEN; GLUCOSE; HYDROXYL RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROSTANE; MANNITOL; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; ACETYLSALICYLIC ACID; DRUG DERIVATIVE; ISOPROSTANE DERIVATIVE; NORADRENALIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPIN TRAPPING; STREPTOZOCIN DIABETES; THORACIC AORTA; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HYPERGLYCEMIA; METABOLISM; MUSCLE RELAXATION; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ACETYLCHOLINE; ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AORTA, THORACIC; ASPIRIN; COMPARATIVE STUDY; DIABETES MELLITUS, EXPERIMENTAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; GENE EXPRESSION; GLUCOSE; HYDROXYL RADICAL; HYPERGLYCEMIA; ISOPROSTANES; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NITRIC OXIDE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES; SUPPORT, U.S. GOV'T, P.H.S.; VASODILATION; ANIMALS;

ANIMALIA;

EID: 0036591859     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00832-8     Document Type: Article

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