Impairment of endothelium dependent relaxation in the diabetic rat heart: Mechanisms and implications

Diabetes Research and Clinical Practice

Volumn 31, Issue SUPPL., 1996, Pages

  Rösen, Peter ^a   Ballhausen, Thomas ^a   Stockklauser, Karin ^a  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Coronary vessels; Diabetes; Endothelium; Myocardium; NO synthetase; Streptozotocin diabetes; Superoxide anions; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ARGININE; CITRULLINE; INDOMETACIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; SEROTONIN; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART PERFUSION; ISOLATED HEART; MALE; NONHUMAN; RAT; STREPTOZOCIN DIABETES; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0041025099     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-8227(96)01242-9     Document Type: Conference Paper

References (59)

1. Furchgott, R. and Zawadski, J. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (London) 288, 373-376.
2. Moncada, S. and Higgs, A. (1993) Mechanisms of disease: the L-arginine-nitric oxide pathway. N. Engl. J. Med. 329, 2002-2012.
3. Förstermann, U., Closs, E.I., Pollock, J.S., Nakane, M., Schwarz, P., Gath, I. and Kleinert, H. (1994) Nitric oxide synthase isozymes: characterization, purification, molecular cloning, and functions. Hypertension 23, 1121-1131.
4. Nathan, C. and Xie, Q. (1994) Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918.
5. Tsao, P.S., Theilmeier, G., Singer, A.M., Leung, L.L.K. and Cooke, J.P. (1994) L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Arterioscler. Thromb. 14, 1529-1533.
6. Tsao, P.S., McEvoy, L.L., Drechsler, H., Butcher, E.C. and Cooke. J.P. (1994) Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation 89, 2176-2182.
7. Gaboury, J., Woodman, R.C., Granger, D., Reinhardt, P. and Kubes, P. (1993) Nitric oxide prevents leukocyte adherence: role of superoxide. Am. J. Physiol. 265, H862-H867.
8. 2-analogues and an NO (EDRF)-donor: a comparison between platelets of healthy and diabetic subjects. Platelets 5, 45-52.
9. Garg, U.C. and Hassid, A. (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest. 83, 1774-1777.
10. Toda, N. and Okamura, T. (1991) Role of nitric oxide in neurally induced cerebroarterial relaxation. J. Pharmacol. Exp. Ther. 258, 1027-1032.
11. Romano, F.D., Kopp, S.J., Darr, J.T. and Smith, C.A. (1994) The antiadrenergic effect of cycloadenosine on myocardial contractility is reduced in vivo in diabetic rats. Can. J. Physiol. Pharmacol. 72, 1245-1251.
12. Burton, K.P. (1988) Evidence of direct toxic effects of free radicals on the myocardium. Free Radical Biol. Med. 4, 15-24.
13. Bhambi, B. and Eghmali, M. (1991) Effect of norepinephrine on myocardial collagene expression and response of cardiac fibroblasts after norepinephrine treatment. Am. J. Pathol. 139, 1131-1142.
14. Pelouch, V., Dixon, I.M.C., Golfman, L., Beamish, R. E. and Dhalla, N.S. (1993) Role of extracellular matrix proteins in heart function. Mol. Cell. Cardiol. 129, 101-120.
15. Ludmer, P.L., Selwyn, A.P., Shook, T.L., Wayne, R.R., Mudge, G.H., Wayne, R.R., Alexander, R. and Ganz, P. (1986) Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N. Engl. J. Med. 315, 1046-1051.
16. Zeiher, A.M., Drexler, H., Wollschläger, H. and Just, H. (1991) Modulation of coronary vasomotor tone in humans: progressive dysfunction with different early stages of coronary artherosclerosis. Circulation 83, 391-401.
17. Brush, J.E., Faxon, D.P., Salmon, S., Jacobs, A.K. and Ryan, T.J. (1992) Abnormal endothelium-dependent coronary vasomotion in hypertensive patients. J. Am. Coll. Cardiol. 19, 809.
18. Cohen, R.A. (1993) Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87 (Suppl.5), V67-V76.
19. Williamson, J.R., Chang, K., Frangos, M., Hasan, K.S., Ido, Y., Kawamura, T., Nyengaard, J.R., van den Enden, M., Kilo, C. and Tilton, R.G. (1993) Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42, 801-813.
20. Nitenberg, A., Valensi, P., Sachs, R., Dali, M., Aptecar, E. and Attali, J.R. (1993) Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes 42, 1017.
21. Rösen, P., Ballhausen, Th., Bloch, W. and Addicks, K. (1995) Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant. Diabetologia 38, 1157-1168.
22. Rösen, P., Rösen, R., Hohl, C., Reinauer, H. and Klaus, W. (1984) Reduced transcoronary exchange and prostaglandin synthesis in diabetes rat heart. Am. J. Physiol. 247, H563-H569.
23. Rösen, P., Windeck, P., Zimmer, H.G., Frenzel, H., Bürrig, K.F. and Reinauer, H. (1986) Myocardial performance in non-ketotic, diabetic rats hearts: myocardial function and metabolism in the isolated perfused heart under the influence of insulin and octanoate. Bas. Res. Cardiol. 81, 620-635.
24. Linssen, M.C.J.G., Willemsen, P.H.M., Heijnen, V.V.Th. and van der Vusse, G.J. (1992) Arachidonic acid incorporation in cardiomyocytes, endothelial cells and fibroblast-like cells isolated from adult rat heart. Mol. Cell. Biochem. 116, 203-209.
25. Thomas, J., Linssen, M., van der Vusse, G.J., Hirsch, B., Rösen, P., Kammermeier, H. and Fischer, Y. (1995) Acute stimulation of glucose transport by histamine in cardiac microvascular endothelial cells. Biochim. Biophys. Acta 1268, 88-96.
26. Voyta, J.C., Via, D.P., Butterfield, C.E. and Zetter, B.R. (1984) Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell. Biol. 99, 2034-2040.
27. Jaffe, E.A., Hoyer, L.W. and Nachman, R.L. (1973) Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J. Clin. Invest. 52, 2757-2764.
28. Bredt, D.S. and Snyder, S.H. (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc. Natl. Acad. Sci. USA 87, 682-685.
29. Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, E.R. and Chaudhuri, G. (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA 84, 9265-9269.
30. Spackmann, D.H., Stein, W.H. and Moore, S. (1958) Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 30, 1190-1205.
31. Kawasaki, E.S. (1991) Amplification of RNA. In: M.A. Innis, D.H. Gelfand, D.H. Sinsky and T.J. White (Eds.), PCR protocols: a guide to methods and applications. Academic Press, San Diego, CA, pp. 21-27.
32. Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidiniumthiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-160.
33. Hu, A.L.W., Alessio, J.M.D., Gerard, G.F. and Kullman, J. (1991) RT-catalyzed first strand synthesis and the amplification of β-actin mRNA using polymerase chain reaction. BRL-Focus 13, 26-29.
34. Bucala, R., Tracey, K.J. and Cerami, A. (1991) Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J. Clin. Invest. 87, 432-438.
35. Yan, S.D., Schmidt, A.M., Anderson, G.M., Zhang, J., Brett, J., Zou, Y.S., Pinsky, D. and Stern, D. (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/ binding proteins. J. Cell. Biol. 269, 9889-9897.
36. Meraji, S., Jayakoby, L., Senaratne, M.P., Thompson, A.B. and Kappagoda, T. (1987) Endothelium-dependent relaxation in aorta of BB rat. Diabetes 36, 978-981.
37. Wakabayashi, I., Hatake, K., Kimura, N., Kakishita, E. and Nagai, K. (1987) Modulation of vascular tone by the endothelium in experimental diabetes. Life Sci. 40, 643-648.
38. Oyama, Y., Kawasaki, H., Hattori, Y. and Kanno, M. (1986) Attenuation of endothelium-dependent relaxation in aortae of diabetic rats. Eur. J. Pharmacol. 131, 75-78.
39. Kamata, K., Miyata, N. and Kasuya, Y. (1989) Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 97, 614-618.
40. Pieper, G.M. and Gross, G.J. (1988) Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol. 255, H825-H833.
41. Kappagoda, T., Jayakody, L., Rajotte, R., Thomson, A.B. and Senaratne, M.P. (1989) Endothelium-dependent relaxation to acetylcholine in the aorta of streptozotocin induced diabetic-rat and the BB-diabetic rat. Clin. Invest. Med. 12, 187-193.
42. 2. Am. J. Physiol. 257, H1327-H1333.
43. Diederich, D., Skopec, J., Diederich, A. and Dai, F.X. (1994) Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am. J. Physiol. 266, H1153-H1161.
44. Chiba, S., Karasawa, Y., Adahane, K. and Ken, L.M. (1990) Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB, 1881-FU, in isolated canine heart preparation. Jpn. Heart J. 290, 173-184.
45. Mertens, H., Ballhausen, T., Hollweg, H.G., Kirkpatrick, J.C. and Kammermeier, H. (1994) Alteration of vascular endothelium and endothelium smooth muscle interaction after carbogen gas perfusion of isolated rat and guinea pig heart. Bas. Res. Cardiol. 89, 322-340.
46. Mankad, P.S., Chester, A.H. and Yacoub, M.H. (1991) 5-Hydroxytryptamine mediates endothelium dependent coronary vasodilatation in the isolated rat heart by the release of nitric oxide. Cardiovasc. Res. 25, 244-248.
47. James, G.M., Hodgson, W.C., Davis, E.A. and Haynes, J.M. (1994) Attenuated 5-hydroxytryptamine receptor-mediated responses in aortae from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 111, 370-376.
48. Pieper, G.M., Langenstroer, P. and Gross, G.J. (1993) Hydroxyl radicals mediate injury to endothelium-dependent relaxation in diabetic rat. Mol. Cell. Biochem. 122, 139-145.
49. Langenstroer, P. and Pieper. G.M. (1992) Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen radicals. Am. J. Physiol. 263, H257-H265.
50. Gryglewski, R.J., Palmer, R.M.J. and Mocada, S. (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320, 454-456.
51. Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. and Freeman, B.A. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87, 1620-1624.
52. Lyons, T.J. (1991) Oxidised low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabetes Med. 8, 411-419.
53. Rösen, P. and Tschöpe, D. (1991) Vitamin E and diabetes. Fat Sci. Technol. 93, 425-431.
54. Hunt, J.V., Smith, C.T. and Wolff, S.P. (1990) Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39, 1420-1424.
55. Wolff, S.P. and Dean, R.T. (1987) Glucose autoxidation and protein modification. The potential role of oxidative glycosylation in diabetes. Biochem. J. 245, 243-250.
56. Tesfamariam, B., Brown, M.L. and Cohen, R.A. (1991) Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C. J. Clin. Invest. 87, 1643-1648.
57. Pieper, G.M. and Peltier, B.A. (1995) Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J. Cardiovasc. Pharmacol. 25, 397-403.
58. Cooke, J.P., Singer, A.H., Tsao, P., Zera, P., Rowan, R.A. and Billingham, M.E. (1992) Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J. Clin. Invest. 90, 1168-1172.
59. Wang, B., Singer, A.H., Tsao, P., Drexler, H., Kosek, J. and Cooke, J.P. (1994) Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit. J. Am. Coll. Cardiol. 23, 452-458.