Impairment of endothelium-dependent but not of endothelium-independent dilatation in guinea-pig aorta rings incubated in the presence of elevated glucose

British Journal of Pharmacology

Volumn 121, Issue 5, 1997, Pages 972-976

  Dorigo, P ^a   Fraccarollo, D ^a   Santostasi, G ^a   Maragno, I ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Adenosine; ATP; Endothelium; Glucose; Vasodilatation

Indexed keywords

4 AMINOPYRIDINE; ACETYLCHOLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM ION; GLUCOSE; INDOMETACIN; MANNOSE; MEFENAMIC ACID; NITROPRUSSIDE SODIUM; NORADRENALIN; PURINE DERIVATIVE; RESERPINE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARACHIDONIC ACID METABOLISM; ARTERY DILATATION; ARTERY TONE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; FEMALE; GUINEA PIG; HYPERGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; AORTA, THORACIC; CYCLOOXYGENASE INHIBITORS; ENDOTHELIUM, VASCULAR; FEMALE; GLUCOSE; GUINEA PIGS; MALE; MANNOSE; MUSCLE CONTRACTION; RECEPTORS, PURINERGIC P2; RESERPINE; VASODILATION; VASODILATOR AGENTS;

EID: 0030925246     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701203     Document Type: Article

References (49)

1. ADAMS, D.J. (1994). Ionic channels in vascular endothelial cells. Trends Cardiovasc. Med., 4, 18-26.
2. BOEYNAEMS, J.M. & PEARSON, J.D. (1990). P2 purinoceptors on vascular endothelial cell: Physiological significance and transduction mechanisms. Trends Pharmacol. Sci., II, 34-37.
3. BOHLEN, H.G. & LASH, J.M. (1993). Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles. Am. J. Physiol., 265 (Heart Circ. Physiol., 34), H219-H225.
4. BORN, G.V. & KRATZER, M.A.A. (1984). Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man. J. Physiol., 354, 419.
5. BROWNLEE, M., CERAMI, A. & VILASSARA, H. (1988). Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. New Engl. J. Med., 318, 1315-1321.
6. CALVER, A., COLLIER, J. & VALLANCE, P. (1992). Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J. Clin. Invest., 90, 2548-2554.
7. CHERRY, P.D. & GILLIS, C.N. (1988). Antagonism of acetylcholine-mediated relaxation of rabbit pulmonary arteries by phorbol myristate acetate. J. Pharmacol. Exp. Ther., 247, 542-549.
8. COLLIS, M.G. & BROWN, C.M. (1983). Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular site. Eur. J. Pharmacol., 96, 61-69.
9. DE MEY, J.G. & VANHOUTTE, P.M. (1981). Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J. Physiol., 316, 347-355.
10. FLAVAHAN, N.A. (1992). Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation, 85, 1927-1938.
11. FLAVAHAN, N.A., SHIMOKAWA, H. & VANHOUTTE, P.M. (1991). Inhibition of endothelium-dependent relaxations by phorbol myristate acetate in canine coronary arteries: role of a pertussis toxin-sensitive G protein. J. Pharmacol. Exp. Ther., 256, 50-55.
12. FREIMAN, P.C., MITCHELL, G.G., HEISTAD, D.D., ARMSTRONG, M.L. & HARRISON, D.G. (1986). Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ. Res., 58, 783-789.
13. FURCHGOTT, R.F. (1983). Role of endothelium in responses of vascular smooth muscle. Circ. Res., 53, 557-573.
14. GAWLER, D., MILLIGAN, G., SPIEGEL, A.M., UNSON, C.G. & HOUSLAY, M. (1987). Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes. Nature, 327, 229-232.
15. GORDON, J.L. & MARTIN, W. (1983). Endothelium-dependent relaxation of the pig aorta: relationship to stimulation of 86Rb efflux from isolated endothelial cells. Br. J. Pharmacol., 79, 531-541.
16. GREEN, A. & JOHNSON, J.L. (1991). Evidence for impaired coupling of receptors to Gi protein in adipocytes from streptozocin-induced diabetic rats. Diabetes, 40, 88-94.
17. HATTORI, Y., KAWASAKI, H., ABE, K. & KANNO, M. (1991). Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol., 261 (Heart Circ. Physiol., 30), H1086-H1094.
18. HEADRICK, J.P. & BERNE, R.M. (1990). Endothelium-dependent and -independent relaxations to adenosine in guinea-pig aorta. Am. J. Physiol., 259 (Heart Circ. Physiol., 28), H62-H67.
19. HSUEH, W.A. & ANDERSON, P.W. (1992). Hypertension, the endothelial cell and the vascular complications of diabetes mellitus. Hypertension, 20, 253-263.
20. IWAKI, M., NAKAYA, Y., KAWANO, K., MIZOBUCHI, S., NAKAYA, S. & MORI, N. (1988). Tetraethylammonium-induced contraction of rabbit coronary artery. Heart Vessels, 4, 141.
21. JAYAKODY, R.L., SENARATNE, M.P., THOMSON, A.B.R. & KAPPAGODA, C.T. (1985). Cholesterol feeding impairs endothelium-dependent relaxation of rabbit aorta. Can. J. Physiol. Pharmacol. 63, 1206-1209.
22. KARASU, Ç. & ALTAN, M. (1993). The role of the endothelial cells on the alterations in vascular reactivity induced by insulin-dependent diabetes mellitus: effect of insulin treatment. Gen. Pharmacol., 24, 743-755.
23. KU, D.D. (1982). Coronary vascular reactivity after acute myocardial ischemia. Science (Wash. DC), 218, 576-578.
24. KUBO, S.H., RECTOR, T.S., BANK, A.J., WILLIAMS, R.F. & HEIFETZ, S.M. (1991). Endothelium-dependent vasodilatation is attenuated in patients with heart failure. Circulation, 84, 1589-1596.
25. LAMBERT, C.R. & PEPINE, C. (1983). A new model for coronary artery spasm. Clin. Res., 31, 866.
26. LAMPING, K.G. & DOLE, P. (1987). Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo. Circ. Res., 61, 904-913.
27. MAYHAN, W.G. (1989). Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus. Am. J. Physiol., 256 (Heart Circ. Physiol., 25). H621-H625.
28. MAYHAN, W.G., SIMMONS, L.K. & SHARPE, G.M. (1991). Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. Am. J. Physiol., 260 (Heart Circ. Physiol., 29), H319-H326.
29. MCCORD, J.M. & FRIDOVICH, I. (1969). Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprein). J. Biol. Chem., 244, 6049-6055.
30. MCVEIGH, G.E., BRENNAN, G.M., JOHNSTON, G.D., MCDERMOTT, B.J., GRATH, L.T., HENRY, W.R., ANDREWS, J.W. & HAYES, J.R. (1992). Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 35, 771-776.
31. MONCADA, S., PALMER, R.M. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-141.
32. MORRISON, K.J. & POLLOCK, D. (1990). Impairment of relaxations to acetylcholine and nitric acid by a phorbol ester in rat isolated aorta. Br. J. Pharmacol., 101, 432-437.
33. NEEDHAM, L., CUSACK, N.J., PEARSON, J.D. & GORDON, J.L. (1987). Characteristic of the P2 purinoceptor that mediates prostacyclin production by pig aortic endothelial cells. Eur. J. Pharmacol., 134, 199-209.
34. OYAMA, Y., KAWASAKI, H., HATTORI, Y. & KANNO, M. (1986). Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur. J. Pharmacol., 132, 75-78.
35. PANZA, J.A., QUYYUMI, A.A., BRUSH, J.E. & EPSTEIN, S.E. (1990). Abnormal endothelium-dependent relaxation in patients with essential hypertension. N. Engl. J. Med., 323, 22-27.
36. PIEPER, G.M. & GROSS, G.J. (1988). Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol., 255 (Heart Circ. Physiol., 24), H825-H833.
37. RAPPOPORT, R.M. & MURAD, F. (1983). Agonist-induced endothelial-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res., 52, 353-357.
38. ROSS, G., STINSON, E., SCHROEDER, J. & GINSBURG, R. (1980). Spontaneous phasic activity of isolated human coronary arteries. Cardiovasc. Res., 14, 613-618.
39. SAENZ DE TEJADA, I., GOLDSTEIN, I., AZADZOI, K. & COHEN, R.A. (1989). Impaired neurogenic and endothelium dependent relaxation of human penile smooth muscle: The pathophysiological basis for impotence in diabetes mellitus. N. Engl. J. Med., 320, 1025-1030.
40. TEMMA, K., AKERA, T., BRODY, T.M. & MANNIAN, A.A. (1977). Hydroxylated chlorpromazine metabolites: Positive inotropic action and the release of catecholamines. Mol. Pharmacol., 13, 1076-1085.
41. TESFAMARIAM, B. (1994). Free radicals in diabetic endothelial cell dysfunction. Free Radical Biol. Med., 16, 383-391.
42. TESFAMARIAM, B., BROWN, M.L., DEYKIN, D. & COHEN, R.A. (1990). Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J. Clin. Invest., 85, 929-932.
43. TESFAMARIAM, B., JAKUBOWSKI, J.A. & COHEN, R.A. (1989). Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TXA2. Am. J. Physiol., 257 (Heart Circ. Physiol., 26), H1327-H1333.
44. UCHIDA, Y. & SUGIMOTO, T. (1984). Decreasing potassium conductance: a possible mechanism of the development of coronary vasospasm. Fed. Proc., 43, 429.
45. UCHIDA, Y. (1985). Decreased potassium conductance. A possible mechanism of phasic coronary vasospasm. Jap. Circ. J., 49, 128-139.
46. VALENTOVIC, M.A. & LUBAY, W.C. (1985). Elevated glucose in vivo and in vitro adversely alters prostaglandin generation in rat aortae and platelets. Prostaglandins Leukotrienes Med., 19, 271-277.
47. WEISBROD, R.M., BROWN, M.L. & COHEN, R.A. (1993). Effect of elevated glucose on cyclic GMP and eicosanoids produced by porcine aortic endothelium. Arterioscler. Tromb., 13, 915-923.
48. WENNALM, Å. (1994). Endothelial nitric oxide and cardiovascular disease. J. Int. Med., 235, 317-327.
49. WHITE, T.D. (1988). Role of adenine compounds in autonomic neurotransmission. Pharmacol. Ther., 38, 129-168.